Results 1 to 10 of about 2,749,540 (299)
Neuroprotection in a Novel Mouse Model of Multiple Sclerosis [PDF]
, 2013 The authors acknowledge the support of the Barts and the London Charity, the Multiple Sclerosis Society of Great Britain and Northern Ireland, the National Multiple Sclerosis Society, USA, notably the National Centre for the Replacement, Refinement ...
A Compston +49 more
core +24 more sources
Frontiers in Immunology, 2021 Chronic hepatotropic viral infections are characterized by exhausted CD8+ T cells in the presence of cognate antigen in the liver. The impairment of T cell response limits the control of chronic hepatotropic viruses.
Kingsley Gideon Kumashie +8 more
doaj +1 more source
Advances in Rodent Models for Breast Cancer Formation, Progression, and Therapeutic Testing
Frontiers in Oncology, 2021 Breast cancer is a highly complicated disease. Advancement in the treatment and prevention of breast cancer lies in elucidation of the mechanism of carcinogenesis and progression.
Chong Liu +3 more
doaj +1 more source
Asian Journal of Andrology, 2022 Klinefelter syndrome (KS) is one of the most frequent genetic abnormalities and the leading genetic cause of nonobstructive azoospermia. The breeding and study of KS mouse models are essential to advancing our knowledge of the underlying pathological ...
Hai-Xia Zhang +8 more
doaj +1 more source
Analysis of genome-wide knockout mouse database identifies candidate ciliopathy genes
Scientific Reports, 2022 We searched a database of single-gene knockout (KO) mice produced by the International Mouse Phenotyping Consortium (IMPC) to identify candidate ciliopathy genes.
Kendall Higgins +35 more
doaj +1 more source
Equine Polyclonal Antibodies Prevent Acute Chikungunya Virus Infection in Mice
Viruses, 2023 Chikungunya virus (CHIKV) is a mosquito-transmitted pathogen that causes chikungunya disease (CHIK); the disease is characterized by fever, muscle ache, rash, and arthralgia.
Douglas Barker +9 more
doaj +1 more source
Mouse Models of Aneuploidy [PDF]
The Scientific World Journal, 2012 Abnormalities of chromosome copy number are called aneuploidies and make up a large health load on the human population. Many aneuploidies are lethal because the resulting abnormal gene dosage is highly deleterious. Nevertheless, some whole chromosome aneuploidies can lead to live births. Alterations in the copy number of sections of chromosomes, which
Olivia Sheppard +4 more
openaire +5 more sources
A Super-Microsurgery Training Model: The Mouse Caudal Artery Anastomosis Model
Frontiers in Surgery, 2022 ObjectiveTo establish a simple and practical model for super-microsurgery training using the middle caudal arteries of Kunming mice.MethodsA ⊔-shaped incision was made approximately 1 cm from the root of the tail in the mouse, and the skin, together with
Xue-Qiang Wu +6 more
doaj +1 more source
Molecular Psychiatry, 1999 Psychiatric disorders have important genetic contributions, but it has been very difficult to identify the responsible genes using human populations. Recent developments in mouse genomics hold considerable promise of providing important insights into the genetics of these diseases.
V, Brown, D, Smith
openaire +2 more sources
Generation of an immunodeficient mouse model of tcirg1-deficient autosomal recessive osteopetrosis
Bone Reports, 2020 Background: Autosomal recessive osteopetrosis is a rare skeletal disorder with increased bone density due to a failure in osteoclast bone resorption. In most cases, the defect is cell-autonomous, and >50% of patients bear mutations in the TCIRG1 gene ...
Eleonora Palagano +16 more
doaj +1 more source