Results 21 to 30 of about 1,587,863 (170)

Construction and characterization of an infectious cDNA clone of coxsackievirus A 10

Virology Journal, 2019
Background Coxsackievirus A10 (CA10) constitutes one of the four major pathogens causing hand, foot and mouth disease in infants. Infectious clones are of great importance for studying viral gene functions and pathogenic mechanism.
Qiliang Liu, Hanliang Dan, Xiaoping Zhao, Huoying Chen, Yongbei Chen, Ning Zhang, Zhijing Mo, Hongbo Liu   +7 more
doaj   +1 more source

A fast, simple, and cost-effective method of expanding patient-derived xenograft mouse models of pancreatic ductal adenocarcinoma

Journal of Translational Medicine, 2020
Background Patient-derived xenograft (PDX) mouse models of cancer have been recognized as better mouse models that recapitulate the characteristics of original malignancies including preserved tumor heterogeneity, lineage hierarchy, and tumor ...
Zhenyang Liu, Michael Ho-Young Ahn, Tomohiro Kurokawa, Amy Ly, Gong Zhang, Fuyou Wang, Teppei Yamada, Ananthan Sadagopan, Jane Cheng, Cristina R. Ferrone, Andrew S. Liss, Kim C. Honselmann, Gregory R. Wojtkiewicz, Soldano Ferrone, Xinhui Wang   +14 more
doaj   +1 more source

Endometriosis in the Mouse: Challenges and Progress Toward a ‘Best Fit’ Murine Model

Frontiers in Physiology, 2022
Endometriosis is a prevalent gynecologic condition associated with pelvic pain and infertility characterized by the implantation and growth of endometrial tissue displaced into the pelvis via retrograde menstruation.
Katherine A. Burns, Amelia M. Pearson, Jessica L. Slack, Elaine D. Por, Alicia N. Scribner, Nazmin A. Eti, Richard O. Burney, Richard O. Burney   +7 more
doaj   +1 more source

The role of mouse models in colorectal cancer research—The need and the importance of the orthotopic models

Animal Models and Experimental Medicine, 2020
Colorectal cancer is a worldwide health burden, with high incidence and mortality, especially in the advanced stages of the disease. Preclinical models are very important and valuable to discover and validate early and specific biomarkers as well as new ...
Rui C. Oliveira, Ana Margarida Abrantes, José Guilherme Tralhão, Maria Filomena Botelho   +3 more
doaj   +1 more source

A serological biomarker of type I collagen degradation is related to a more severe, high neutrophilic, obese asthma subtype

Asthma Research and Practice, 2022
Background Asthma is a heterogeneous disease; therefore, biomarkers that can assist in the identification of subtypes and direct therapy are highly desirable. Asthma is a chronic inflammatory disease that leads to changes in the extracellular matrix (ECM)
Sarah Rank Rønnow, Jannie Marie Bülow Sand, Line Mærsk Staunstrup, Thomas Bahmer, Michael Wegmann, Lars Lunding, Janette Burgess, Klaus Rabe, Grith Lykke Sorensen, Oliver Fuchs, Erika V. Mutius, Gesine Hansen, Matthias Volkmar Kopp, Morten Karsdal, Diana Julie Leeming, Markus Weckmann, the ALLIANCE Study Group as part of the German Center of Lung Research (DZL)   +16 more
doaj   +1 more source

Developmental aspect of decidual patterning

Reproductive and Developmental Medicine, 2017
In clinical practice, early pregnancy loss has afflicted approximately 15%–25% women of reproductive age worldwide, which is partially attributed to defects associated with the endometrium.
Chan Zhou, Hai-Li Bao, Shuang-Bo Kong, Jin-Hua Lu, Hai-Bin Wang   +4 more
doaj   +1 more source

Loss of Sult1a1 reduces body weight and increases browning of white adipose tissue

Frontiers in Endocrinology
Background and objectiveOverweight and obesity affects millions of individuals worldwide and consequently represents a major public health concern. Individuals living with overweight and obesity have difficulty maintaining a low body weight due to known ...
Margherita Springer, Margherita Springer, Emmanuelle Meugnier, Katharina Schnabl, Katharina Schnabl, Katharina Schnabl, Kevin Sebastiaan Hof, Marie-France Champy, Tania Sorg, Benoit Petit-Demoulière, Natacha Germain, Natacha Germain, Bogdan Galusca, Bogdan Galusca, Bruno Estour, Bruno Estour, Hubert Vidal, Martin Klingenspor, Martin Klingenspor, Martin Klingenspor, Jörg Hager   +20 more
doaj   +1 more source

Dominant effects of the immediate environment on the gut microbiome of mice used in biomedical research

mSystems
Studies using genetically engineered mouse (GEM) models are often performed over extended periods. The microbiomes of GEM colonies are expected to retain some of the microbial features present in the founder mice used to generate each GEM model and to ...
Aaron C. Ericsson, Zachary L. McAdams, Rebecca A. Dorfmeyer, Marcia L. Hart, Armedia O’Neill-Blair, James Amos-Landgraf, Craig L. Franklin   +6 more
doaj   +1 more source

The Apoe-/- Mouse PhysioLab® Platform: A Validated Physiologically-based Mathematical Model of Atherosclerotic Plaque Progression in the Apoe-/- Mouse [PDF]

BioDiscovery, 2012
<em>Motivation:</em>Atherosclerosis is a complex multi-pathway inflammatory disease where accumulation of oxidatively modified lipids and leukocytes in the arterial intima leads to plaque formation over time ...
Jason R Chan, Gregory Vuillaume, Caitlin Bever, Stefan Lebrun, Michael Lietz, Yvonne Steffen, Katrin Stolle, Karim Wahba, Xiao Wang, Shonna Moodie, Julia Hoeng, Manuel C Peitsch, Lyn M Powell   +12 more
doaj   +3 more sources

Bmpr2 mutant mice are an inadequate model for studying iron deficiency in pulmonary hypertension

Pulmonary Circulation, 2022
As bone morphogenetic protein receptor type II (Bmpr2) mutations are the most common genetic cause of pulmonary arterial hypertension (PAH), and iron deficiency (ID) is associated with worse clinical outcomes in PAH patients, we proposed to use Bmpr2 ...
Vida Zhang, Tomas Ganz, Elizabeta Nemeth, Soban Umar, Airie Kim   +4 more
doaj   +1 more source