Results 41 to 50 of about 1,587,863 (170)

A new mouse model of typhoid fever using Salmonella enterica serovar Paratyphi C as a surrogate pathogen

mBio
Salmonella enterica serovar (S.) Typhi, the etiological agent of typhoid fever, is strictly human adapted, which presents a significant challenge for studying its pathogenesis in animal models.
Hoan T. Pham, Masatomo Morita, Kohei Yamazaki, Toshihiro Endo, Satoshi Takayama, Azusa Hiyoshi, Takeshi Haneda, Renée M. Tsolis, Andreas J. Bäumler, Toshio Kodama, Hirotaka Hiyoshi   +10 more
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Rutin ameliorates cigarette smoke mediated lung inflammation in a mouse model of chronic obstructive pulmonary disease via regulating the levels of tumor necrosis factor-α, interleukin-8 and PAF

Archives of Medical Science, 2020
Introduction Rutin is a plant-derived flavonoid. In the present work we screened the activity of rutin in a cigarette smoke induced lung disease mouse model of chronic obstructive pulmonary disease (COPD). Material and methods The mice were subjected to
Juan Chen, Jinyu Su, Lingyun Dong, Zhiyu Bai, Yufeng Liu, Hongju Bao, Yanfang Lu, Yajuan Wu   +7 more
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Persistent articular infection and host reactive response contribute to Brucella-induced spondyloarthritis in SKG mice

mBio
Brucellosis, one of the most prevalent zoonotic diseases worldwide, often results in osteoarticular complications including large joint and axial arthritis mimicking spondyloarthritis.
Jerome S. Harms, Michael Lasarev, Thomas Warner, Sergio Costa Oliveira, Judith A. Smith   +4 more
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Revisiting the mouse model of oxygen-induced retinopathy

Eye and Brain, 2016
Clifford B Kim,1,2 Patricia A D’Amore,2–4 Kip M Connor1,2 1Angiogenesis Laboratory, Massachusetts Eye and Ear, 2Department of Ophthalmology, Harvard Medical School, 3Schepens Eye Research Institute, Massachusetts Eye and Ear, 4Department of ...
Kim CB, D'Amore PA, Connor KM
doaj  

Analysis of in vitro and in vivo metabolism of zidovudine and gemfibrozil in trans‐chromosomic mouse line expressing human UGT2 enzymes

Pharmacology Research & Perspectives, 2022
UDP‐glucuronosyltransferases (UGTs) catalyze the conjugation of various substrates with sugars. Since the UGT2 family forms a large cluster spanning 1.5 Mb, transgenic mouse lines carrying the entire human UGT2 family have not been constructed because of
Kaoru Kobayashi, Tsuneo Deguchi, Satoshi Abe, Naoyo Kajitani, Kanako Kazuki, Shoko Takehara, Kazuomi Nakamura, Atsushi Kurihara, Mitsuo Oshimura, Yasuhiro Kazuki   +9 more
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The Effect of Nano-Silver on Allergic Rhinitis Model in Mice [PDF]

Clinical and Experimental Otorhinolaryngology, 2012
ObjectivesSilver has long been known as a strong antimicrobial and disinfectant. Several types of nano-silver coated products have been developed. However, the antimicrobial and disinfectant characteristics of nano-silver have not been well studied.
Seung-Heon Shin, Mi-Kyung Ye
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Editorial: Phenotyping mouse embryos

Frontiers in Cell and Developmental Biology, 2023
Stefan H. Geyer, Dorota Szumska, Gabriel G. Martins, Wolfgang J. Weninger   +3 more
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Muscle-specific kinase levels in blood are an early diagnostic biomarker for SOD1-93A mouse model of ALS

Frontiers in Neurology
Neuromuscular junction (NMJ) denervation is an early event preceding motor neuron loss in amyotrophic lateral sclerosis (ALS). Progressive loss of the NMJ leads to irreversible muscle weakness and atrophy. Muscle-specific kinase (MuSK), locally expressed
Shuuichi Mori, Heying Zhou, Takuya Omura, Hiroki Tsumoto, Yuri Miura, Kazuhiro Shigemoto   +5 more
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Species-Dependent Functionality of the Human Cytolytic Fusion Proteins Granzyme B-H22(scFv) and H22(scFv)-Angiogenin in Macrophages

Antibodies, 2013
Human cytolytic fusion proteins (hCFPs) are comprised of a specific cell-surface-binding moiety and an effector molecule of human origin. In contrast to common immunotoxins, including bacterial or plant toxins, they are considered not to be immunogenic ...
Theo Thepen, Stefan Barth, Rainer Fischer, Michael Huhn, Radoslav Mladenov, Eric Aslanian, Dmitrij Hristodorov, Sonja Schiffer   +7 more
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Acute perioperative-stress-induced increase of atherosclerotic plaque volume and vulnerability to rupture in apolipoprotein-E-deficient mice is amenable to statin treatment and IL-6 inhibition

Disease Models & Mechanisms, 2015
Myocardial infarction and stroke are frequent after surgical procedures and consume a considerable amount of benefit of surgical therapy. Perioperative stress, induced by surgery, is composed of hemodynamic and inflammatory reactions.
Henrike Janssen, Christian S. Wagner, Philipp Demmer, Simone Callies, Gesine Sölter, Houra Loghmani-khouzani, Niandan Hu, Harald Schuett, Uwe J. F. Tietge, Gregor Warnecke, Jan Larmann, Gregor Theilmeier   +11 more
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