Results 41 to 50 of about 2,749,540 (299)

Loss of Sult1a1 reduces body weight and increases browning of white adipose tissue

Frontiers in Endocrinology
Background and objectiveOverweight and obesity affects millions of individuals worldwide and consequently represents a major public health concern. Individuals living with overweight and obesity have difficulty maintaining a low body weight due to known ...
Margherita Springer, Margherita Springer, Emmanuelle Meugnier, Katharina Schnabl, Katharina Schnabl, Katharina Schnabl, Kevin Sebastiaan Hof, Marie-France Champy, Tania Sorg, Benoit Petit-Demoulière, Natacha Germain, Natacha Germain, Bogdan Galusca, Bogdan Galusca, Bruno Estour, Bruno Estour, Hubert Vidal, Martin Klingenspor, Martin Klingenspor, Martin Klingenspor, Jörg Hager   +20 more
doaj   +1 more source

Dominant effects of the immediate environment on the gut microbiome of mice used in biomedical research

mSystems
Studies using genetically engineered mouse (GEM) models are often performed over extended periods. The microbiomes of GEM colonies are expected to retain some of the microbial features present in the founder mice used to generate each GEM model and to ...
Aaron C. Ericsson, Zachary L. McAdams, Rebecca A. Dorfmeyer, Marcia L. Hart, Armedia O’Neill-Blair, James Amos-Landgraf, Craig L. Franklin   +6 more
doaj   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

A novel therapeutic strategy for pancreatic neoplasia using a novel RNAi platform targeting PDX-1 [PDF]

, 2011
Bi-functional shRNA (bi-shRNA), a novel RNA interference (RNAi) effector platform targeting PDX-1 utilizing a systemic DOTAP-Cholesterol delivery vehicle, was studied in three mouse models of progressive pancreatic neoplasia.
Charles Brunicardi, David Dawson, Donald Rao, Francesco DeMayo, John Nemunaitis, Kelly Stehling, Marie-Claude Gingras, Michael Norman, Nancy Templeton, Neil Senzer, Richard Gibbs, Shi-He Liu, William Fisher, Zhaohui Wang   +13 more
core   +1 more source

Neurocardiovascular deficits in the Q175 mouse model of Huntington's disease. [PDF]

, 2017
Cardiovascular dysautonomia as well as the deterioration of circadian rhythms are among the earliest detectable pathophysiological changes in individuals with Huntington's disease (HD). Preclinical research requires mouse models that recapitulate disease
Colwell, Christopher S, Cutler, Tamara S, Ghiani, Cristina A, Jordan, Maria C, Loh, Dawn H, Park, Saemi, Roos, Kenneth P, Yokota, Tomohiro   +7 more
core   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Preclinical Ultrasound Imaging—A Review of Techniques and Imaging Applications

Frontiers in Physics, 2020
Ultrasound imaging is a well-established clinical imaging technique providing real-time, quantitative anatomical and physiological information in humans.
Carmel M. Moran, Adrian J. W. Thomson
doaj   +1 more source

A Upf3b-mutant mouse model with behavioral and neurogenesis defects. [PDF]

, 2018
Nonsense-mediated RNA decay (NMD) is a highly conserved and selective RNA degradation pathway that acts on RNAs terminating their reading frames in specific contexts.
Cook-Andersen, H, Dumdie, J, Espinoza, JL, Gecz, J, Huang, L, Jolly, LA, Jones, SH, Kim, H, Lou, C-H, Phan, MH, Roberts, AJ, Shum, EY, Skarbrevik, DM, Swerdlow, NR, Wilkinson, MF   +14 more
core   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Weight loss is a sufficient and economical single outcome measure of murine dextran sulfate sodium colitis

FASEB BioAdvances, 2019
Inflammatory bowel diseases (IBD: Crohn's disease and ulcerative colitis) are becoming common around the world without a cure. Animal models of colitis have become instrumental in IBD research.
Savini Lanka Britto, Mahesh Krishna, Richard Kellermayer   +2 more
doaj   +1 more source