Results 101 to 110 of about 2,928,215 (296)

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Diagnostic criteria for mild cognitive impairment in Parkinson's disease: Movement Disorder Society Task Force guidelines [PDF]

, 2012
Mild cognitive impairment is common in nondemented Parkinson's disease (PD) patients and may be a harbinger of dementia. In view of its importance, the Movement Disorder Society commissioned a task force to delineate diagnostic criteria for mild ...
Charles H. Adler, Dag Aarsland, Schmand, Ben A., Karen Marder, Emre, Murat, Alexander I. Tröster, Kulisevsky, Jaime, Caroline H. Williams-Gray, Mollenhauer, Brit, Daniel Weintraub, Adler, Charles H., Maria C. Rodriguez-Oroz, Roger A. Barker, Aarsland, Dag, Troester, Alexander I., Ronald C. Petersen, Litvan, Irene, Ben A. Schmand, Burn, David J., Murat Emre, David J. Burn, Burns, David J., Jaime Kulisevsky, Petersen, Ronald C., Jennifer G. Goldman, Tröster, Alexander I., Barker, Roger A., Irene Litvan, Brit Mollenhauer, Weintraub, Daniel, Goldman, Jennifer G., Marder, Karen, Rodriguez-Oroz, Maria C., Williams-Gray, Caroline H.   +33 more
core   +1 more source

Is faciobrachial dystonic seizure a misnomer? A case report of atypical leg-predominant tonic-dystonic attacks in LGI1-associated encephalitis

BMC Neurology
Background Antibody‑mediated encephalitis due to leucine‑rich glioma‑inactivated 1 (LGI1) is a frequent cause of immune‑responsive paroxysmal motor phenomena in older adults.
Malika Faouzi, Alexandra Galati, Suman Kaza, Michiko K. Bruno   +3 more
doaj   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Hyperactive ice‐binding proteins stabilize cell membranes and improve resistance to dehydration stress in Caenorhabditis elegans

FEBS Open Bio, EarlyView.
TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose, Kotaro Ozaki, Ryohei Kuriyama, Yuka Ikemoto, Kazuhiro Mio, Yuji C. Sasaki, Tatsuya Arai, Sakae Tsuda, Yoichi Shinkai, Masahiro Kuramochi   +9 more
wiley   +1 more source

Allergic disease as a risk factor for Parkinson’s disease: a possible role of eosinophil

npj Parkinson's Disease
Neuroinflammation is central to Parkinson’s disease (PD) pathogenesis and allergic inflammation may contribute to PD risk, but evidence is limited. Using the Korean National Health Insurance Service database, we conducted a cohort study of 5,036,518 ...
Hee Jin Chang, Su Hyeon Ha, So-Hee Lee, Seungmin Lee, Chanhee Jeong, Jung Hwan Shin, Han-Joon Kim, Heung-Woo Park   +7 more
doaj   +1 more source

Induction of tau pathology and motor dysfunction in mice by urinary exosomes from progressive supranuclear palsy patients

Brain Research Bulletin
Background: Progressive supranuclear palsy (PSP) is characterized by the presence of hyperphosphorylated and misfolded tau aggregates in neurons and glia.
Qiusha Li, Han Liu, Qingyong Zhu, Rui Zhang, Dongxiao Liang, Jingwen Zhang, Ruoqi Jin, Yongkang Chen, Chi Qin, Junfang Teng   +9 more
doaj   +1 more source

Exploring the influence of lactoferrin on wound healing and related signaling pathways: a systematic review

FEBS Open Bio, EarlyView.
Lactoferrin promotes wound healing by activating MAPK, PI3K/Akt, and extracellular matrix pathways, enhancing fibroblast remodeling, proliferation, and re‐epithelialization. These mechanisms highlight its therapeutic potential in inflammation control, tissue repair, and remodeling.
Morgana Lüdtke Azevedo, Kátia Cristiane Hall, Matheus dos Santos Fernandez, Geovanna Peter Corrêa, Rafael Guerra Lund   +4 more
wiley   +1 more source