Results 111 to 120 of about 2,928,215 (296)

Shared pathway-specific network mechanisms of dopamine and deep brain stimulation for the treatment of Parkinson’s disease

Nature Communications
Deep brain stimulation is a brain circuit intervention that can modulate distinct neural pathways for the alleviation of neurological symptoms in patients with brain disorders.
Thomas S. Binns, Richard M. Köhler, Jojo Vanhoecke, Meera Chikermane, Moritz Gerster, Timon Merk, Franziska Pellegrini, Johannes L. Busch, Jeroen G. V. Habets, Alessia Cavallo, Jean-Christin Beyer, Bassam Al-Fatly, Ningfei Li, Andreas Horn, Patricia Krause, Katharina Faust, Gerd-Helge Schneider, Stefan Haufe, Andrea A. Kühn, Wolf-Julian Neumann   +19 more
doaj   +1 more source

Cognitive and affective Theory of Mind abilities in Parkinson’s disease before and 1 year after subthalamic deep brain stimulation

Frontiers in Human Neuroscience
BackgroundParkinson’s disease (PD) is associated with specific cognitive deficits and dysfunctions in Theory of Mind (ToM), which can impact patients’ quality of life. ToM refers to the ability to infer the mental and emotional state of one’s counterpart
Anna Elsenbach, Melanie Astalosch, Luísa Martins Ribeiro, Elias Landfried, Patricia Krause, Gerd-Helge Schneider, Gregor A. Brandt, Andrea A. Kühn, Andrea A. Kühn, Andrea A. Kühn, Dorothee Kübler-Weller   +10 more
doaj   +1 more source

KDAC6 alters cell morphology and motility through positive and negative modulation of F‐actin distribution

FEBS Open Bio, EarlyView.
KDAC6 has been associated with cell motility and actin structures, but specific domain contributions are not established. The two catalytic domains have differential effects on motility and F‐actin regulation, affecting cortical F‐actin density, motility, stress fibers, and cell spreading.
Taylor V. Joseph, Andrea B. Pham, Kiara E. Bornes, Razan H. Hammad, Chelsea A. Rousseve‐Ross, Thomas M. Huckaba, Terry J. Watt, Tasha B. Toro   +7 more
wiley   +1 more source

Evolution‐guided yeast complementation reveals functional differences in human PSPH variants

FEBS Open Bio, EarlyView.
Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez, Diana Ascencio, Miguel Vallebueno‐Estrada, Eduardo González‐Orozco, Christian Eduardo Martínez‐Guerrero, Rafael Montiel, Alexander DeLuna   +6 more
wiley   +1 more source

Decoding the impact of visual states on adaptive deep brain stimulation feedback signals in movement disorders

npj Parkinson's Disease
We investigated the impact of visual states on basal ganglia oscillatory biomarkers, comparing local field potentials (LFPs) dynamics between Parkinson’s disease (PD) and dystonia and developing a decoding model for state identification.
Guan-Yu Zhu, Timon Merk, Konstantin Butenko, Zi-Xiao Yin, Ying-Chuan Chen, Ning-Fei Li, Thomas Binns, Ruo-Yu Ma, Ting-Ting Du, Yu-Ye Liu, Hu-Tao Xie, Lin Shi, An-Chao Yang, Fan-Gang Meng, Andrea A. Kühn, Jian-Guo Zhang, Wolf-Julian Neumann   +16 more
doaj   +1 more source

Heterotropic regulation and negative homotropic cooperativity

FEBS Open Bio, EarlyView.
We identified a structural module common to some proteins that couple negative cooperativity with heterotropic regulation, two features that rarely coexist. These proteins are ring‐like and present an ordered asymmetry whereby noncontacting subunits are symmetric, and their tertiary structure differs from that of contacting subunits.
Veronica Morea, Francesco Angelucci, Federica Arnesano, Gianmarco Pascarella, Patrizio Di Micco, Andrea Bellelli   +5 more
wiley   +1 more source

Minipolymyoclonus: A Critical Appraisal [PDF]

Journal of Movement Disorders, 2021
Jacky Ganguly, Jia Ren Chai, Mandar Jog
doaj   +1 more source

From patient advocacy to patient‐driven research: Building active partnerships beginning at the bench to reach the bedside

FEBS Open Bio, EarlyView.
Research is strongest when conducted alongside patients, not just about them. Patient research organizations help integrate patient perspectives into research priorities, study design, and scientific meetings, leading to meaningful patient outcomes and development of relevant therapies.
Jenica H. Kakadia, Rachel Heilmann, Maximiliano Barrientos, Laura MacNeill, Ingrid Vallee, Sarah K. Schultz, Patrick O'Donoghue, Angelica A. Moresco, Victoria M. Siu, Ilka U. Heinemann   +9 more
wiley   +1 more source

Multiple system atrophy: Diagnostic challenges and a proposed diagnostic algorithm

Clinical Parkinsonism & Related Disorders
Multiple system atrophy (MSA) is a heterogenous condition, presenting with core clinical features of autonomic dysfunction, parkinsonism, and/or cerebellar ataxia. The presence of alpha-synuclein glial cytoplasmic inclusion is the hallmark of MSA.
Deepmala Nandanwar, Daniel D. Truong
doaj   +1 more source

The C‐terminal domain of yeast Arginyltransferase1 is essential for its catalytic activity

FEBS Open Bio, EarlyView.
Arginyltransferase 1 (Ate1), a eukaryotic enzyme, catalyses arginylation, transferring arginine from tRNA‐Arg to the amino terminus of the target protein. Overexpression of Ate1 in yeast is lethal and is dependent on arginylation. This study elucidates how mutations in the cofactor‐binding and active site of Ate1 and truncation of its structural ...
Vikas Kumar Yadav, Shweta Shweta, Manisha Malhotra, Vikash Maurya, Akhilesh Kumar   +4 more
wiley   +1 more source