Results 1 to 10 of about 6,564 (158)

Efficacy and Safety of Moxidectin, Synriam, Synriam-Praziquantel versus Praziquantel against Schistosoma haematobium and S. mansoni Infections: A Randomized, Exploratory Phase 2 Trial. [PDF]

PLoS Neglected Tropical Diseases, 2016
BACKGROUND:Schistosomiasis affects millions of people, yet treatment options are limited. The antimalarial Synriam (piperaquine 150 mg/arterolane 750 mg) and the anthelminthic moxidectin revealed promising antischistosomal properties in preclinical or ...
Beatrice Barda, Jean T Coulibaly, Maxim Puchkov, Jörg Huwyler, Jan Hattendorf, Jennifer Keiser   +5 more
doaj   +9 more sources

The potential impact of moxidectin on onchocerciasis elimination in Africa: an economic evaluation based on the Phase II clinical trial data [PDF]

Parasites & Vectors, 2015
Background Spurred by success in several foci, onchocerciasis control policy in Africa has shifted from morbidity control to elimination of infection. Clinical trials have demonstrated that moxidectin is substantially more efficacious than ivermectin in ...
Hugo C Turner, Martin Walker, Simon K Attah, Nicholas O Opoku, Kwablah Awadzi, Annette C Kuesel, María-Gloria Basáñez   +6 more
doaj   +3 more sources

Analyses of emerging macrocyclic lactone resistance: Speed and signature of ivermectin and moxidectin selection and evidence of a shared genetic locus. [PDF]

PLoS Pathogens
Subtherapeutic treatment or 'underdosing' is considered a common problem in the control of parasitic helminths of animals and people and can hasten the emergence of anthelmintic resistance.
Jennifer McIntyre, Alison Morrison, Kirsty Maitland, Eileen Devaney, James A Cotton, Collette Britton, Ray M Kaplan, Dave Bartley, Roz Laing   +8 more
doaj   +2 more sources

A pilot study on the potency of injectable vs. oral moxidectin formulation to suppress strongyle egg excretion in horses at twice lower dose [PDF]

Helminthologia
The aim of present study was to examine the potency of moxidectin solution (Cydectin 1 %; Zoetis) and commercially available oral moxidectin gel (Equest®; Zoetis) to suppress the excretion of strongyle eggs in horses over a 6-week period.
Šarkūnas M., Schwahn A., Suleimanova K.   +2 more
doaj   +2 more sources

Identification of a moxidectin dose for 4- to 11-year-old children to support registration and potential use for onchocerciasis elimination: results of an open-label pharmacokinetic and safety study [PDF]

Parasites & Vectors
Background The WHO and onchocerciasis-endemic countries target elimination of the transmission of Onchocerca volvulus, the parasite causing onchocerciasis, primarily through ivermectin mass drug administration (MDA).
Nicholas O. Opoku, Felix Doe, Mannel E. Agbogah, Rukaya Laryea, Shelter K. Gordor, Bismark S. Donkor, Edwin Anyomitse, Dickson Kugali, Mariëlle van Zutphen-van Geffen, Danielle J. Navarro, Craig R. Rayner, Kashyap Patel, Annette C. Kuesel, Melinda Lowe, Sally Kinrade   +14 more
doaj   +2 more sources

Development of a UHPLC-MS/MS Method for the Determination of Moxidectin in Rat Plasma and Its Application in Pharmacokinetics [PDF]

Molecules
The aim of the present study was to establish a simple and reliable ultra-high-performance liquid chromatography tandem mass spectrometry (UHPLC-MS/MS) method and apply it for the determination of pharmacokinetics of moxidectin-loaded microspheres (MOX ...
Hongjuan Zhang, Zhen Yang, Baocheng Hao, Di Wu, Dan Shao, Yu Liu, Wanxia Pu, Shouli Yi, Ruofeng Shang, Shengyi Wang   +9 more
doaj   +2 more sources

Pharmacokinetics of oral moxidectin in individuals with Onchocerca volvulus infection.

PLoS Neglected Tropical Diseases, 2022
BackgroundOnchocerciasis ("river blindness"), is a neglected tropical disease caused by the filarial nematode Onchocerca volvulus and transmitted to humans through repeated bites by infective blackflies of the genus Simulium.
Beesan Tan, Nicholas Opoku, Simon K Attah, Kwablah Awadzi, Annette C Kuesel, Janis Lazdins-Helds, Craig Rayner, Victoria Ryg-Cornejo, Mark Sullivan, Lawrence Fleckenstein   +9 more
doaj   +1 more source

Bugs and drugs: a systems biology approach to characterising the effect of moxidectin on the horse’s faecal microbiome

Animal Microbiome, 2020
Background Anthelmintic treatment is a risk factor for intestinal disease in the horse, known as colic. However the mechanisms involved in the onset of disease post anthelmintic treatment are unknown.
S. P. Daniels, J. Leng, J. R. Swann, C. J. Proudman   +3 more
doaj   +1 more source

Efficacy of imidacloprid 10%/moxidectin 1% spot-on formulation (Advocate®) in the prevention and treatment of feline aelurostrongylosis [PDF]

, 2020
Background: In three randomized, controlled laboratory efficacy studies, the efficacy in the prevention of patent infections of a topical combination of imidacloprid 10%/moxidectin 1% (Advocate® spot-on formulation for cats, Bayer Animal Health GmbH ...
Blazejak, Katrin, Deuster, Katrin, Heuer, Lea, McKay-Demeler, Janina, Petry, Gabriele, Pollmeier, Matthias, Samson-Himmelstjerna, Georg von, Schaper, Roland, Schmidt, Holger, Strube, Christina   +9 more
core   +1 more source

Comparative efficacy of Moxidectin and Ivermectin in cattle naturally infected with old world screw worm larvae [PDF]

Iraqi Journal of Veterinary Sciences, 2005
Moxidectin is a second generation semi-synthetic Macrocyclic Lactone of the Milbemycins family, which have a broad spectrum of activity against external and internal parasite including Oestrus ovis and hypodermatosis.
E A Hassan, A Y Al-Karogholli, A S Hassan, M O Al-Ani   +3 more
doaj   +1 more source