Results 11 to 20 of about 9,249 (288)

Efficacy and Safety of Moxidectin, Synriam, Synriam-Praziquantel versus Praziquantel against Schistosoma haematobium and S. mansoni Infections: A Randomized, Exploratory Phase 2 Trial. [PDF]

PLoS Neglected Tropical Diseases, 2016
BACKGROUND:Schistosomiasis affects millions of people, yet treatment options are limited. The antimalarial Synriam (piperaquine 150 mg/arterolane 750 mg) and the anthelminthic moxidectin revealed promising antischistosomal properties in preclinical or ...
Beatrice Barda, Jean T Coulibaly, Maxim Puchkov, Jörg Huwyler, Jan Hattendorf, Jennifer Keiser   +5 more
doaj   +9 more sources

A review of moxidectin vs. other macrocyclic lactones for prevention of heartworm disease in dogs with an appraisal of two commercial formulations

Frontiers in Veterinary Science
Macrocyclic lactones (MLs) are the only drug class currently licensed for heartworm disease prophylaxis. Macrocyclic lactones kill third- and fourth-stage larvae of Dirofilaria immitis, thus preventing the development of adult worms in dogs, which are ...
Kennedy Mwacalimba, Jenifer Sheehy, Christopher Adolph, Molly Savadelis, Kristina Kryda, Barbara Poulsen Nautrup   +5 more
doaj   +2 more sources

Successful Removal of Angiostrongylus cantonensis Larvae from the Central Nervous System of Rats 7- and 14-Days Post-Infection Using a Product Containing Moxidectin, Sarolaner and Pyrantel Embonate (Simparica Trio™) in Experimental Infections [PDF]

Pathogens, 2023
Angiostrongylus cantonensis is a nematode with an indirect lifecycle, using molluscs as intermediate hosts. Rats are the definitive host. By administering a suitable anthelmintic, at an appropriate interval, the risk of clinical neuroangiostrongyliasis ...
Michael Henry, R. Malik, J. Šlapeta, Rogan Lee   +3 more
semanticscholar   +2 more sources

The potential impact of moxidectin on onchocerciasis elimination in Africa: an economic evaluation based on the Phase II clinical trial data [PDF]

Parasites & Vectors, 2015
Background Spurred by success in several foci, onchocerciasis control policy in Africa has shifted from morbidity control to elimination of infection. Clinical trials have demonstrated that moxidectin is substantially more efficacious than ivermectin in ...
Hugo C Turner, Martin Walker, Simon K Attah, Nicholas O Opoku, Kwablah Awadzi, Annette C Kuesel, María-Gloria Basáñez   +6 more
doaj   +3 more sources

A Randomized, Single-Ascending-Dose, Ivermectin-Controlled, Double-Blind Study of Moxidectin in Onchocerca volvulus Infection

PLoS Neglected Tropical Diseases, 2014
BackgroundControl of onchocerciasis as a public health problem in Africa relies on annual mass ivermectin distribution. New tools are needed to achieve elimination of infection.
Annette C Kuesel
exaly   +2 more sources

Safety and tolerability of moxidectin and ivermectin combination treatments for lymphatic filariasis in Côte d'Ivoire: A randomized controlled superiority study.

PLoS Neglected Tropical Diseases, 2023
BackgroundMoxidectin is a macrocyclic lactone registered for the treatment of human onchocerciasis. The drug has a good safety profile, large volume of distribution and a long elimination half-life. This paper reports tolerability data from the first use
Catherine M Bjerum, Benjamin G Koudou, Allassane F Ouattara, Daphne Lew, Charles W Goss, Pascal T Gabo, Christopher L King, Peter U Fischer, Gary J Weil, Philip J Budge   +9 more
doaj   +2 more sources

A pilot study on the potency of injectable vs. oral moxidectin formulation to suppress strongyle egg excretion in horses at twice lower dose [PDF]

Helminthologia
The aim of present study was to examine the potency of moxidectin solution (Cydectin 1 %; Zoetis) and commercially available oral moxidectin gel (Equest®; Zoetis) to suppress the excretion of strongyle eggs in horses over a 6-week period.
Šarkūnas M., Schwahn A., Suleimanova K.   +2 more
doaj   +2 more sources

Efficacy of oral, topical and extended-release injectable formulations of moxidectin combined with doxycycline in Dirofilaria immitis naturally infected dogs

Parasites & Vectors, 2023
Background Several studies in both experimentally and naturally infected dogs have reported the adulticide effect of a combination of macrocyclic lactones and doxycycline against Dirofilaria immitis, showing that these protocols can be used as an ...
Lavinia Ciuca, Alice Vismarra, Dario Constanza, Antonio Di Loria, Leonardo Meomartino, Paolo Ciaramella, Giuseppe Cringoli, Marco Genchi, Laura Rinaldi, Laura Kramer   +9 more
doaj   +2 more sources

Identification of a moxidectin dose for 4- to 11-year-old children to support registration and potential use for onchocerciasis elimination: results of an open-label pharmacokinetic and safety study [PDF]

Parasites & Vectors
Background The WHO and onchocerciasis-endemic countries target elimination of the transmission of Onchocerca volvulus, the parasite causing onchocerciasis, primarily through ivermectin mass drug administration (MDA).
Nicholas O. Opoku, Felix Doe, Mannel E. Agbogah, Rukaya Laryea, Shelter K. Gordor, Bismark S. Donkor, Edwin Anyomitse, Dickson Kugali, Mariëlle van Zutphen-van Geffen, Danielle J. Navarro, Craig R. Rayner, Kashyap Patel, Annette C. Kuesel, Melinda Lowe, Sally Kinrade   +14 more
doaj   +2 more sources

Efficacy of a combination of 10% imidacloprid and 1% moxidectin against Caparinia tripilis in African pygmy hedgehog (Atelerix albiventris) [PDF]

Parasites & Vectors, 2012
Background The efficacy and safety of a combination formulation of 10% imidacloprid + 1.0% moxidectin spot-on (Advocate® for Cats, Bayer Animal Health GmbH, Leverkusen, Germany) was tested in 40 African pygmy hedgehogs (Atelerix albiventris) naturally ...
Kim Kyu-Rim, Ahn Kyu-Sung, Oh Dae-Sung, Shin Sung-Shik   +3 more
doaj   +2 more sources