Moxidectin elevates Candida albicans ergosterol levels to synergize with polyenes against oral candidiasis. [PDF]
Appl Microbiol BiotechnolCandida albicans, the most common opportunistic pathogenic fungus, is also the main pathogenic organism for oral candidiasis. This condition is particularly prevalent among the elderly, children, and individuals undergoing radiotherapy or suffering from ...
Ye X +12 more
europepmc +2 more sources
Open Parasitology Journal, 2023 Topically applied antiparasitic drugs used in dogs have evolved in terms of active ingredients, but progress has also been made through the development of drugs that control both ectoparasites and enteroparasites (nematodes and cestodes).
C. R. Núñez +3 more
semanticscholar +2 more sources
Moxidectin induces lethal autophagy arrest via CFTR [PDF]
, 2022 Abstract Colorectal cancer (CRC) is a cancer with a high morbidity and mortality worldwide. Hence， developing new therapeutic drugs for CRC is very important. Moxidectin (MOX) has shown good anti-glioblastoma effect both in vitro and in vivo, This study aimed to elucidate the anti-CRC effect of MOX and its potential mechanism.
Yushan Mao +5 more
openalex +2 more sources
Moxidectin and the avermectins: Consanguinity but not identity
International Journal for Parasitology: Drugs and Drug Resistance, 2012 The avermectins and milbemycins contain a common macrocyclic lactone (ML) ring, but are fermentation products of different organisms. The principal structural difference is that avermectins have sugar groups at C13 of the macrocyclic ring, whereas the milbemycins are protonated at C13.
Roger K Prichard
exaly +5 more sources
Revista Brasileira de Parasitologia Veterinária, 2017 Cyathostomins are the most prevalent nematodes of horses, and multidrug resistance has been reported worldwide. There is a need to implement alternative drug monitoring analytical tests.
Marcelo Beltrão Molento +1 more
doaj +2 more sources
Safety of moxidectin in avermectin-sensitive Collies [PDF]
American Journal of Veterinary Research, 2000 Abstract Objective—To evaluate the safety of moxidectin administration at doses of 30, 60, and 90 µg/kg of body weight (10, 20, and 30 times the manufacturer's recommended dose) in avermectin-sensitive Collies. Animals—24 Collies. Procedure—Collies with mild to severe reactions to ivermectin challenge (120 mg/kg; 20 times ...
Allan J. Paul +2 more
openalex +3 more sources
Efficacy of a novel chewable tablet (Credelio Quattro<sup>™</sup>) containing lotilaner, moxidectin, praziquantel, and pyrantel against Toxocara canis and Toxascaris leonina infections in dogs. [PDF]
Parasit VectorsCharles S +7 more
europepmc +3 more sources
Efficacy of Sustained-Release Formulation of Moxidectin (Guardian SR) in Preventing Heartworm Infection over 18 Months in Dogs Living in a Hyperendemic Area [PDF]
AnimalsThis study investigates the efficacy of a sustained-release (SR) moxidectin microsphere formulation in preventing canine heartworm infection over 18 months in Canary Hound dogs, a hunting breed common in the Canary Islands, which is a hyperendemic region.
Agustina Isabel Quintana-Mayor +2 more
doaj +2 more sources
Solvatomorphism of Moxidectin [PDF]
Molecules, 2021 The solvatomorphism of the anthelmintic drug moxidectin is investigated, and a new solvatomorph with nitromethane is reported. Moreover, the hitherto unknown crystal structures of the solvatomorphs with ethanol and 2-propanol are reported and discussed.
Grell, Toni +4 more
openaire +5 more sources
Efficacy of Credelio Quattro<sup>™</sup> (lotilaner, moxidectin, pyrantel, praziquantel) and Credelio<sup>™</sup> (lotilaner) against longhorned tick, Haemaphysalis longicornis,-induced infestations on dogs. [PDF]
Parasit VectorsWiseman S +5 more
europepmc +3 more sources