Results 11 to 20 of about 69,250 (228)

A single <i>JAK2</i>-V617F hematopoietic stem cell can initiate myeloproliferative neoplasm when transplanted into non-conditioned recipient mice. [PDF]

Hemasphere
Abstract Myeloproliferative neoplasms (MPNs) are clonal disorders of hematopoietic stem cells (HSCs) that are most frequently caused by acquired somatic mutations in JAK2. A number of conditional mouse models of JAK2‐V617F‐driven MPN have been generated that rely on Cre‐LoxP‐mediated activation, resulting in polyclonal disease.
Kimmerlin Q, Hilpert M, Hansen N, Guy A, Usart M, Stetka J, Sobieralski P, Almeida Fonseca T, Hao-Shen H, Skoda RC.   +9 more
europepmc   +2 more sources

Downregulating Notch counteracts KrasG12D-induced ERK activation and oxidative phosphorylation in myeloproliferative neoplasm. [PDF]

, 2019
The Notch signaling pathway contributes to the pathogenesis of a wide spectrum of human cancers, including hematopoietic malignancies. Its functions are highly dependent on the specific cellular context. Gain-of-function NOTCH1 mutations are prevalent in
Chang, Yuan-I, Hofmann, Inga, Kong, Guangyao, Letson, Christopher, Liu, Yangang, Loh, Mignon, Padron, Eric, Pear, Warren S, Qian, Shuiming, Rajagopalan, Adhithi, Ranheim, Erik A, Stieglitz, Elliot, Wen, Zhi, Yang, David, You, Xiaona, Zhang, Jing, Zhang, Jingfang, Zhang, Xinmin, Zhong, Xuehua, Zhou, Lan, Zhou, Yun   +20 more
core   +1 more source

The 2 faces of ERK2 in MPNs

Blood, 2022
In this issue of Blood, Zhang et al1 reported that extracellular signal-regulated kinase 2 (ERK2) substrate-binding domains have opposing roles in Janus kinase 2 V617F (JAK2V617F)-driven myeloproliferative neoplasms (MPNs). One of the domains, ERK2-docking (ERK2-D), may be a promising therapeutic target for MPNs.
Violaine Havelange, Stefan N. Constantinescu   +1 more
openaire   +3 more sources

Complications after medullary thyroid carcinoma surgery: multicentre study of the SQRTPA and EUROCRINE® databases

BJS (British Journal of Surgery), EarlyView., 2020
This study investigated postoperative complications after surgery for medullary thyroid carcinoma (MTC) in Europe. Hypoparathyroidism, recurrent laryngeal nerve palsy and bleeding requiring reoperation occurred in 170 (26·2 per cent), 62 (13·7 per cent) and 17 (2·6 per cent) patients respectively.
D.‐J. van Beek, M. Almquist, A. O. Bergenfelz, T. J. Musholt, E. Nordenström, on behalf of the EUROCRINE® Council, M. Almquist, M. Barczynski, L. Brunaud, T. Clerici, M. H. Hansen, M. Iacobone, Ö. Makay, F. F. Palazzo, N. Muñoz‐Pérez, M. Raffaelli, P. Riss, S. van Slycke, M. R. Vriens   +18 more
wiley   +1 more source

Myeloproliferative Neoplasien (MPN) [PDF]

, 2014
Das Kapitel 4 beinhaltet eine Zusammenstellung der am Universitatsklinikum Freiburg verwendeten Chemotherapie- und ggf. Studien-Protokolle der Entitat Myeloproliferative Neoplasien (MPN). Dieses ist in die Unterkapitel Chronische Myeloische Leukamie (CML), Polycythemia Vera (PV), Essentielle Thrombozythamie (ET) und Myelofibrose (MF) gegliedert.
Monika Engelhardt, Dietmar Berger, Justus Duyster, Roland Mertelsmann   +3 more
openaire   +1 more source

The SMAC mimetic LCL-161 selectively targets JAK2V617F mutant cells. [PDF]

, 2020
Background:Evasion from programmed cell death is a hallmark of cancer and can be achieved in cancer cells by overexpression of inhibitor of apoptosis proteins (IAPs).
Craver, Brianna M, Fleischman, Angela G, Huynh, Christy, Morse, Sarah J, Nguyen, Hellen, Nguyen, Jenny, Nguyen, Thanh Kim   +6 more
core  

Dynamics of 5-methylcytosine and 5-hydroxymethylcytosine during pronuclear development in equine zygotes produced by ICSI [PDF]

, 2017
Background: Global epigenetic reprogramming is considered to be essential during embryo development to establish totipotency. In the classic model first described in the mouse, the genome-wide DNA demethylation is asymmetric between the paternal and the ...
De Schauwer, Catharina, Heras Garcia, Sonia, Smits, Katrien, Van Soom, Ann   +3 more
core   +1 more source

Advancing the STATus of MPN pathogenesis [PDF]

Blood, 2012
In this issue of Blood, Yan et al1 and Walz et al2 exploit mouse genetics to investigate the contribution of signal transducer and activator of transcription 5 (STAT5) to the abnormal in vivo growth of hematopoietic cells expressing JAK2V617F or BCR-ABL.
Neil P, Shah, Kevin, Shannon
openaire   +2 more sources

Micro-coagulation effects on direct ultrafiltration of challenging raw river water [PDF]

, 2016
Background The feasibility and competitiveness of substituting the conventional pre-treatment of drinking water treatment plants (dioxichlorination, coagulation/flocculation, settling, sand filtration) by raw river water direct ultrafiltration (UF ...
Barbot, Blankert, Boulestreau, Chen, Choi, Clever, Domínguez, Doyen, Edzwald, Edzwald, Fan, Ferrer, Ferrer, Fiksdal, Fitzpatrick, Futselaar, Gibert, Heijman, Hlavacek, Hofman, Howe, Huang, Huber, Hutzinger, Iritani, Jermann, Jiang, Judd, Kim, Konieczny, Konieczny, Lai, Ma, Meyn, Neubrand, Oosterom, Pearce, Pearce, Pianta, Pikkarainen, Rojas, Salinas Rodríguez, Schlichter, Sripui, Tabatabai, Taniguchi, Vos, Wang, Wiesner, Zheng, Zheng, Zularisam, Zupančič   +52 more
core   +2 more sources

Functional stability of HIV-1 envelope trimer affects accessibility to broadly neutralizing antibodies at its apex [PDF]

, 2017
The trimeric envelope glycoprotein spike (Env) of HIV-1 is the target of vaccine development to elicit broadly neutralizing antibodies (bnAbs). Env trimer instability and heterogeneity in principle make subunit interfaces inconsistent targets for the ...
Gift, Syna Kuriakose, Kim, Arthur S, Leaman, Daniel P, Zhang, Lei, Zwick, Michael B   +4 more
core   +2 more sources