Results 11 to 20 of about 7,965 (221)

Mpox (formerly monkeypox): pathogenesis, prevention and treatment

Signal Transduction and Targeted Therapy, 2023
In 2022, a global outbreak of Mpox (formerly monkeypox) occurred in various countries across Europe and America and rapidly spread to more than 100 countries and regions. The World Health Organization declared the outbreak to be a public health emergency
Junjie Lu, Hui Xing, Chunhua Wang, Mengjun Tang, Changcheng Wu, Fan Ye, Lijuan Yin, Yang Yang, Wenjie Tan, Liang Shen   +9 more
doaj   +2 more sources

Epidemiology and phylogenomic characterisation of two distinct mpox outbreaks in Kinshasa, DR Congo, involving a new subclade Ia lineage: a retrospective, observational study [PDF]

Lancet, The
Background: Clade I monkeypox virus is endemic in DR Congo. We aim to describe the epidemiological trends of the cocirculating subclades Ia and Ib mpox outbreaks in Kinshasa, DR Congo.
Ahuka-Mundeke, Steve, Akil-Bandali, Prince, Amuri-Aziza, Adrienne, Ayouba, Ahidjo, Dantas, Pedro H\ L F, De Block, Tessa, Delaporte, Eric, Halbrook, Megan, Hasivirwe Vakaniaki, Emmanuel, Hensley, Lisa E, Hoff, Nicole A, Jansen, Daan, Kacita, Cris, Kelvin, David J, Kindrachuk, Jason, Kinganda-Lusamaki, Eddy, Kwete-Mbokama, Papy, Liesenborghs, Laurens, Lokilo-Lofiko, Emmanuel, Low, Nicola, Luakanda-Ndelemo, Gradi, Makangara-Cigolo, Jean-Claude, Mapenzi-Kashali, Nelson, Mauro Rezende, Antonio, Mbala-Kingebeni, Placide, Merritt, Sydney, Muswamba-Kayembe, Chloé, Muyembe-Tamfum, Jean-Jacques, Mwamba, Dieudonné, O'Toole, Áine, Ola-Mpumbe, Rilia, Paku-Tshambu, Princesse, Peeters, Martine, Ponga-Museme, Ange, Pratt, Catherine, Pukuta-Simbu, Elisabeth, Rambaut, Andrew, Rimoin, Anne W, Subissi, Lorenzo, Tessema, Sofonias, Tshiani-Mbaya, Olivier, Vercauteren, Koen, Wawina-Bokalanga, Tony   +42 more
core   +3 more sources

Identification of mpox M1R and B6R monoclonal and bispecific antibodies that efficiently neutralize authentic mpox virus

Emerging Microbes & Infections
In 2022, the monkeypox virus (mpox virus, MPXV) exhibited global dissemination across six continents, representing a notable challenge owing to the scarcity of targeted antiviral interventions. Passive immunotherapy, such as the use of monoclonal antibodies (mAbs) and bispecific antibodies (bsAbs), has emerged as a promising option for antiviral ...
Zuning Ren, Mengjun Li, Jiayin Chen, Xiaohua Gong, Shuo Song, Delin Li, Minghui Yang, Jianhai Yu, Sadia Asghar, Yanxin Cui, Shiyu Niu, Zhonghui Liao, Yushan Jiang, Jiahui Liu, Yuqing Li, Bao Zhang, Wei Zhao, Jie Peng, Yang Yang, Chenguang Shen   +19 more
openaire   +5 more sources

Mpox infection investigation using multiplexed syndromic diagnostics: Evaluation of an AusDiagnostics multiplexed tandem PCR (MT-PCR) syndromic panel

Journal of Clinical Virology Plus, 2023
Background: Detection of mpox virus during investigation of viral vesicular rash illness is required to identify mpox infection. Objectives: This study evaluated the performance of a research-use-only (RUO) AusDiagnostics MT-PCR syndromic assay ...
M.J. Pond, J. Al-Mufti, P. Madona, M.A. Crone, K.G. Laing, R.S. Hale, D. Muir, P. Randell   +7 more
doaj   +1 more source

Viroporins of Mpox Virus

International Journal of Molecular Sciences, 2023
Mpox or monkeypox virus (MPXV) belongs to the subclass of Poxviridae and has emerged recently as a global threat. With a limited number of anti-viral drugs available for this new virus species, it is challenging to thwart the illness it begets. Therefore, characterizing new drug targets in the virus may prove advantageous to curbing the disease.
Kingshuk Basu, Miriam Krugliak, Isaiah T. Arkin   +2 more
openaire   +2 more sources

Pharmacological treatment and vaccines in monkeypox virus: a narrative review and bibliometric analysis

Frontiers in Pharmacology, 2023
Mpox (earlier known as monkeypox) virus infection is a recognized public health emergency. There has been little research on the treatment options. This article reviews the specific drugs used to treat mpox virus infection and the vaccines used here ...
Muhammad Aaqib Shamim, Prakisini Satapathy, Bijaya Kumar Padhi, Sai Dutt Veeramachaneni, Naushaba Akhtar, Anindita Pradhan, Abhimanyu Agrawal, Pradeep Dwivedi, Pradeep Dwivedi, Aroop Mohanty, Keerti Bhusan Pradhan, Russell Kabir, Ali A. Rabaan, Jawaher Alotaibi, Zainab A. Al Ismail, Zainab Ahmed Alsoliabi, Ali Al Fraij, Ranjit Sah, Ranjit Sah, Ranjit Sah, Alfonso J. Rodriguez-Morales, Alfonso J. Rodriguez-Morales   +21 more
doaj   +1 more source

Mpox (Formally Known as Monkeypox) [PDF]

, 2023
Mpox originates from the Mpox virus, which belongs to the Orthopoxvirus genus of the Poxviridae family.1, 2, 3 Other Orthopoxvirus species include the variola virus (the now eradicated smallpox virus), vaccinia virus (a virus used in the creation of the ...
Bester, Vanessa, Browne, Frederick, LePage, Tricia, Nemec, Eric C., O\u27Neill, Molly, Yoon, Henry   +5 more
core   +2 more sources

Rapid and sensitive one-tube detection of mpox virus using RPA-coupled CRISPR-Cas12 assay

Cell Reports: Methods, 2023
Summary: Mpox is caused by a zoonotic virus belonging to the Orthopoxvirus genus and the Poxviridae family. In this study, we develop a recombinase polymerase amplification (RPA)-coupled CRISPR-Cas12a detection assay for the mpox virus.
Fei Zhao, Yamei Hu, Zhangling Fan, Baoying Huang, Liang Wei, Yu Xie, Yu Huang, Shan Mei, Liming Wang, Lingwa Wang, Bin Ai, Jugao Fang, Chen Liang, Fengwen Xu, Wenjie Tan, Fei Guo   +15 more
doaj   +1 more source

Assessing the Mpox and Infection Prevention and Control Knowledge of Personal Service Establishments' Operators in Metro Vancouver Regional District of British Columbia [PDF]

, 2023
Mpox virus, formerly known as the Monkeypox virus, is a re-emerging pathogen that causes the infectious disease Mpox. Mpox was designated as a public health emergency of international concern by the World Health Organization due to its rapid spread ...
Chen, Dale, Valeroso, Christian Jefferson   +1 more
core   +2 more sources

Development of a Novel Loop-Mediated Isothermal Amplification Method for the Rapid Detection of Monkeypox Virus Infections

Viruses, 2022
A recent outbreak of monkeypox virus (mpox) has prompted researchers to explore diagnostics as a means of impeding transmission and further spread. Rapid, sensitive, and specific methods are crucial for accurately diagnosing mpox infections.
Chao Yu, Lulu Zuo, Jing Miao, Lingjing Mao, Benjamin Selekon, Ella Gonofio, Emmanuel Nakoune, Nicolas Berthet, Gary Wong   +8 more
doaj   +1 more source