Results 41 to 50 of about 19,153 (149)

A method to estimate probability of disease and vaccine efficacy from clinical trial immunogenicity data

npj Vaccines, 2021
Vaccine efficacy is often assessed by counting disease cases in a clinical trial. A new quantitative framework proposed here (“PoDBAY,” Probability of Disease Bayesian Analysis), estimates vaccine efficacy (and confidence interval) using immune response ...
Julie Dudášová, Regina Laube, Chandni Valiathan, Matthew C. Wiener, Ferdous Gheyas, Pavel Fišer, Justina Ivanauskaite, Frank Liu, Jeffrey R. Sachs   +8 more
doaj   +1 more source

Current Status of Hard Turning in Manufacturing: Aspects of Cooling Strategy and Sustainability

Lubricants, 2023
In recent years, hard turning has been found to be a well-known substitute for traditional grinding for acquiring the finish quality of hardened steel without sacrificing productivity.
Rajashree Mallick, Ramanuj Kumar, Amlana Panda, Ashok Kumar Sahoo   +3 more
doaj   +1 more source

Sequential study of vasculitis in MRL mice [PDF]

Laboratory Animals, 1987
The frequency, age of onset and organ distribution of spontaneously occurring vasculitis was examined in a sequential study with 170 MRL mice of both substrains. Necrotizing vasculitis was seen in 55·8% of MRL/Mp-lpr/lpr mice studied, beginning at the age of 3 months. The kidney and urinary bladder were most frequently involved.
M, Hewicker, G, Trautwein
openaire   +2 more sources

Lipid Traffic Analysis reveals the impact of high paternal carbohydrate intake on offsprings’ lipid metabolism

Communications Biology, 2021
Furse et al. use a purpose-built computational tool called Lipid Traffic Analysis to determine the spatial distribution of lipids throughout an organism.
Samuel Furse, Adam J. Watkins, Nima Hojat, James Smith, Huw E. L. Williams, Davide Chiarugi, Albert Koulman   +6 more
doaj   +1 more source

Effect of dipeptidyl peptidase-4 inhibitors on postprandial glucagon level in patients with type 2 diabetes mellitus: A systemic review and meta-analysis

Frontiers in Endocrinology, 2022
AimsHyperglucagonemia occurs in the pathogenesis of type 2 diabetes mellitus (T2DM). In this meta-analysis, we summarized the effects of DPP4 inhibitors on glucagon levels in patients with T2DM.Materials and methodsRandomized controlled trials (RCTs ...
Shangyu Chai, Ruya Zhang, Ye Zhang, Richard David Carr, Yiman Zheng, Swapnil Rajpathak, Linong Ji   +6 more
doaj   +1 more source

WRN structural flexibility showcased through fragment-based lead discovery of inhibitors

Nature Communications
WRN helicase is an established synthetic lethal target for inhibition in the treatment of microsatellite instability-high (MSI-H) and mismatch repair deficient (MMRd) cancers.
Rachel L. Palte, Mihir Mandal, Justyna Sikorska, Artjohn B. Villafania, Meredith M. Rickard, Robert J. Bauer, Alexei V. Buevich, Xiaomei Chai, Jiafang He, Zahid Hussain, Markus Koglin, Hannah B. MacDonald, My S. Mansueto, Klaus Maskos, Joey L. Methot, Jaclyn Robustelli, Aileen Soriano, Marcel J. Tauchert, Sriram Tyagarajan, Minjia Zhang, Daniel J. Klein, Jacqueline D. Hicks, David G. McLaren, Sandra B. Gabelli, Daniel F. Wyss   +24 more
doaj   +1 more source

Induction and Analysis of Anti-CD40-induced Colitis in Mice

Bio-Protocol, 2019
Colon inflammation or colitis affects more than 1 million people worldwide. Several pre-clinical models, including chemical-induced (i.e., DSS, TNBS) or pathogen-induced (i.e., Citrobacter rodentium) have been used to study mechanisms involved in the ...
Barbara Joyce-Shaikh, Daniel Cua , David Bauché   +2 more
doaj   +1 more source

Abnormal IgG galactosylation and arthritis in MRL‐Fas^lpr or MRL‐FasL^gld mice are under the control of the MRL genetic background

FEBS Letters, 2001
MRL mice bearing the lpr (Fas) or gld (Fas ligand) mutation, MRL‐Faslpr or MRL‐FasLgld , respectively, develop arthritis similar to rheumatoid arthritis, but C3H and C57BL/6 mice bearing such mutations do not. In MRL‐Faslpr mice, agalactosylated oligosaccharides in serum IgG increase significantly in comparison to MRL‐+/+ mice without arthritis.
Kuroda, Yasuhiro, Nakata, Munehiro, Nose, Masato, Kojima, Naoya, Mizuochi, Tsuguo   +4 more
openaire   +2 more sources

Comparative Pathogenicity of United Kingdom Isolates of the Emerging Pathogen Candida auris and Other Key Pathogenic Candida Species

mSphere, 2016
Candida auris, first described in 2009, has since emerged as an important, multidrug-resistant, nosocomial agent of candidemia, with large outbreaks reported worldwide and high mortality rates associated with therapeutic failure.
Andrew M. Borman, Adrien Szekely, Elizabeth M. Johnson   +2 more
doaj   +1 more source

Recent Progress of Potentiating Immune Checkpoint Blockade with External Stimuli—an Industry Perspective

Advanced Science, 2020
The past decade has seen the materialization of immune checkpoint blockade as an emerging approach to cancer treatment. However, the overall response and patient survival are still modest. Various efforts to study the “cancer immunogram” have highlighted
Jun Xu, Robert Saklatvala, Sachin Mittal, Smeet Deshmukh, Adam Procopio   +4 more
doaj   +1 more source