PINES: phenotype-informed tissue weighting improves prediction of pathogenic noncoding variants
Genome Biology, 2018 Functional characterization of the noncoding genome is essential for biological understanding of gene regulation and disease. Here, we introduce the computational framework PINES (Phenotype-Informed Noncoding Element Scoring), which predicts the ...
Corneliu A. Bodea +5 more
doaj +1 more source
GlycoNMR: Dataset and benchmarks for NMR chemical shift prediction of carbohydrates with graph neural networks [PDF]
arXiv, 2023 Molecular representation learning (MRL) is a powerful tool for bridging the gap between machine learning and chemical sciences, as it converts molecules into numerical representations while preserving their chemical features. These encoded representations serve as a foundation for various downstream biochemical studies, including property prediction ...
arxiv
Wrangling environmental exposure data: guidance for getting the best information from your laboratory measurements. [PDF]
, 2019 BACKGROUND:Environmental health and exposure researchers can improve the quality and interpretation of their chemical measurement data, avoid spurious results, and improve analytical protocols for new chemicals by closely examining lab and field quality ...
Dodson, Robin E +3 more
core +1 more source
MRL: Learning to Mix with Attention and Convolutions [PDF]
arXiv, 2022 In this paper, we present a new neural architectural block for the vision domain, named Mixing Regionally and Locally (MRL), developed with the aim of effectively and efficiently mixing the provided input features. We bifurcate the input feature mixing task as mixing at a regional and local scale. To achieve an efficient mix, we exploit the domain-wide
arxiv
, 2013 BACKGROUND: The Malaria Reference Laboratory (MRL) provides a specialist advisory service for complex queries from healthcare professionals. This study was conducted to examine the types of queries that general practitioners and nurses ask around malaria
Blaze, Marie +4 more
core +1 more source
From Galaxy Clusters to Ultra-Faint Dwarf Spheroidals: A Fundamental Curve Connecting Dispersion-supported Galaxies to Their Dark Matter Halos [PDF]
, 2010 We examine scaling relations of dispersion-supported galaxies over more than eight orders of magnitude in luminosity by transforming standard fundamental plane parameters into a space of mass (M1/2), radius (r1/2), and luminosity (L1/2).
Adelman-McCarthy +83 more
core +1 more source
Toll-like receptor 9 suppresses lupus disease in Fas-sufficient MRL Mice
PLoS ONE, 2017 Genetic deficiency in TLR9 accelerates pathogenesis in the spontaneous polygenic MRL.Faslpr murine model of systemic lupus erythematosus, despite the absence of anti-nucleosome autoantibodies. However, it could be argued that this result was dependent on
K. Nickerson +3 more
semanticscholar +1 more source
SAGE Open Medicine, 2017 Introduction: Despite the widespread use of the mouse transverse aortic constriction heart failure model, there are no reports on the characterization of the standard-of-care agent carvedilol in this model. Methods: Left ventricular pressure overload was
Caryn Hampton +13 more
doaj +1 more source
Train Hard, Fight Easy: Robust Meta Reinforcement Learning [PDF]
arXiv, 2023 A major challenge of reinforcement learning (RL) in real-world applications is the variation between environments, tasks or clients. Meta-RL (MRL) addresses this issue by learning a meta-policy that adapts to new tasks. Standard MRL methods optimize the average return over tasks, but often suffer from poor results in tasks of high risk or difficulty ...
arxiv
SERPINB3 delays glomerulonephritis and attenuates the lupus-like disease in lupus murine models by inducing a more tolerogenic immune phenotype [PDF]
, 2018 Objective: To explore the effects of SERPINB3 administration in murine lupus models with a focus on lupus-like nephritis. Methods: 40 NZB/W F1 mice were subdivided into 4 groups and intraperitoneally injected with recombinant SERPINB3 (7.5 \u3bcg/0.1 mL ...
Beggio, M +12 more
core +2 more sources