Results 81 to 90 of about 88,502 (304)
Biostructural, biochemical and biophysical studies of mutant IDH1
Nature CommunicationsWe report bio-structural, bio-chemical and bio-physical evidence demonstrating how small molecules can bind to both wild-type and mutant IDH1, but only inhibit the enzymatic activity of the mutant isoform.
Mark A. McCoy +5 more
doaj +1 more source
From SPMRL to NMRL: What Did We Learn (and Unlearn) in a Decade of Parsing Morphologically-Rich Languages (MRLs)? [PDF]
arXiv, 2020 It has been exactly a decade since the first establishment of SPMRL, a research initiative unifying multiple research efforts to address the peculiar challenges of Statistical Parsing for Morphologically-Rich Languages (MRLs).Here we reflect on parsing MRLs in that decade, highlight the solutions and lessons learned for the architectural, modeling and ...
arxiv
Phenotyping renal leukocyte subsets by four-color flow cytometry: Characterization of chemokine receptor expression [PDF]
, 2003 To investigate mechanisms of cell-mediated injury in renal inflammatory disease it is critical to determine the surface phenotype of infiltrating renal leukocyte subsets.
Anders, Hans-Joachim +5 more
core +1 more source
Journal of Investigative Dermatology, 2015 TNF-like weak inducer of apoptosis (TWEAK, TNFSF12) and its sole receptor Fn14, belonging to the TNF ligand and receptor superfamilies respectively, are involved in cell survival and cytokine production.
J. Doerner +11 more
semanticscholar +1 more source
Journal of Neuroinflammation, 2015 Systemic lupus erythematosus (SLE) is a prototypical autoimmune disease marked by both B and T cell hyperactivity which commonly affects the joints, skin, kidneys, and brain.
Ariel D. Stock +5 more
semanticscholar +1 more source
Frontiers in Endocrinology, 2022 AimsHyperglucagonemia occurs in the pathogenesis of type 2 diabetes mellitus (T2DM). In this meta-analysis, we summarized the effects of DPP4 inhibitors on glucagon levels in patients with T2DM.Materials and methodsRandomized controlled trials (RCTs ...
Shangyu Chai +6 more
doaj +1 more source
Matryoshka Representation Learning [PDF]
arXiv, 2022 Learned representations are a central component in modern ML systems, serving a multitude of downstream tasks. When training such representations, it is often the case that computational and statistical constraints for each downstream task are unknown.
arxiv
Transcriptional responses to hyperplastic MRL signalling inDrosophila [PDF]
Open Biology, 2017 Recent work has implicated the actin cytoskeleton in tissue size control and tumourigenesis, but how changes in actin dynamics contribute to hyperplastic growth is still unclear. Overexpression of Pico, the onlyDrosophilaMig-10/RIAM/Lamellipodin adapter protein family member, has been linked to tissue overgrowth via its effect on the myocardin-related ...
Vincent Jonchère +7 more
openaire +7 more sources
Enhanced activation of dendritic cells by autologous apoptotic microvesicles in MRL/lpr mice
Arthritis Research & Therapy, 2015 IntroductionSystemic lupus erythematosus is associated with a persistent circulation of modified autoantigen-containing apoptotic debris that might be capable of breaking tolerance.
J. Dieker +5 more
semanticscholar +1 more source
Neurobiology of Disease, 2021 TDP-43 pathology is a hallmark of Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal lobar degeneration (FTLD). Namely, both diseases feature aggregated and phosphorylated TDP-43 containing inclusions in the cytoplasm and a loss of nuclear TDP-43 in ...
Yuan Tian +9 more
doaj