Results 91 to 100 of about 1,826,338 (237)
Retrovirology, 2019 Background Mammalian cells harbour RNA quality control and degradative machineries such as nonsense-mediated mRNA decay that target cellular mRNAs for clearance from the cell to avoid aberrant gene expression.
Shringar Rao +5 more
doaj +1 more source
, 2014 The degradation of human ether-a-go-go-related gene (hERG, KCNH2) transcripts containing premature termination codon (PTC)mutations by nonsense-mediatedmRNA decay (NMD) is an importantmechanismof long QT syndrome type 2 (LQT2).
Gong, Qiuming +2 more
core +1 more source
Systematic discovery of structural elements governing stability of mammalian messenger RNAs. [PDF]
, 2012 Decoding post-transcriptional regulatory programs in RNA is a critical step towards the larger goal of developing predictive dynamical models of cellular behaviour.
Cristea, Ileana M +7 more
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Competitive effects in bacterial mRNA decay
Journal of Theoretical Biology, 2020 In living organisms, the same enzyme catalyses the degradation of thousands of different mRNAs, but the possible influence of competing substrates has been largely ignored so far. We develop a simple mechanistic model of the coupled degradation of all cell mRNAs using the total quasi-steady-state approximation of the Michaelis-Menten framework ...
Etienne, Thibault +2 more
openaire +5 more sources
A Upf3b-mutant mouse model with behavioral and neurogenesis defects. [PDF]
, 2018 Nonsense-mediated RNA decay (NMD) is a highly conserved and selective RNA degradation pathway that acts on RNAs terminating their reading frames in specific contexts.
Cook-Andersen, H +14 more
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Nonsense-mediated mRNA decay in mammals [PDF]
Journal of Cell Science, 2005 Nonsense-mediated mRNA decay (NMD) in mammalian cells generally degrades mRNAs that terminate translation more than 50-55 nucleotides upstream of a splicing-generated exon-exon junction (reviewed in [Maquat, 2004a][1]; [Nagy and Maquat, 1998][2]).
openaire +2 more sources
Mechanisms of endonuclease‐mediated mRNA decay [PDF]
WIREs RNA, 2011 AbstractEndonuclease cleavage was one of the first identified mechanisms of mRNA decay but until recently it was thought to play a minor role to the better‐known processes of deadenylation, decapping, and exonuclease‐catalyzed decay. Most of the early examples of endonuclease decay came from studies of a particular mRNA whose turnover changed in ...
openaire +2 more sources
Filtering for nonlinear genetic regulatory networks with stochastic disturbances [PDF]
, 2008 In this paper, the filtering problem is investigated for nonlinear genetic regulatory networks with stochastic disturbances and time delays, where the nonlinear function describing the feedback regulation is assumed to satisfy the sector condition, the ...
Fraser, K +4 more
core +1 more source
ADAR1 controls apoptosis of stressed cells by inhibiting Staufen1-mediated mRNA decay
Nature Structural &Molecular Biology, 2017 Both p150 and p110 isoforms of ADAR1 convert adenosine to inosine in double-stranded RNA (dsRNA). ADAR1p150 suppresses the dsRNA-sensing mechanism that activates MDA5–MAVS–IFN signaling in the cytoplasm.
M. Sakurai +10 more
semanticscholar +1 more source
Molecular Systems Biology, 2016 Precise regulation of mRNA decay is fundamental for robust yet not exaggerated inflammatory responses to pathogens. However, a global model integrating regulation and functional consequences of inflammation‐associated mRNA decay remains to be established.
Vitaly Sedlyarov +10 more
doaj +1 more source