Regulation of cytoplasmic mRNA decay [PDF]
Nature Reviews Genetics, 2012 Discoveries made over the past 20 years highlight the importance of mRNA decay as a means of modulating gene expression and thereby protein production. Up until recently, studies largely focused on identifying cis-acting sequences that serve as mRNA stability or instability elements, the proteins that bind these elements, how the process of translation
Daniel R, Schoenberg, Lynne E, Maquat
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Nonsense mRNA suppression via nonstop decay
eLife, 2018 Nonsense-mediated mRNA decay is the process by which mRNAs bearing premature stop codons are recognized and cleared from the cell. While considerable information has accumulated regarding recognition of the premature stop codon, less is known about the ...
Joshua A Arribere, Andrew Z Fire
doaj +5 more sources
Quality and quantity control of gene expression by nonsense-mediated mRNA decay
Nature Reviews Molecular Cell Biology, 2019 Tatsuaki Kurosaki, M. W. Popp, L. Maquat
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Codon optimality, bias and usage in translation and mRNA decay
Nature Reviews Molecular Cell Biology, 2017 Gavin Hanson, J. Coller
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Regulation of mRNA Decay in Bacteria.
Annual Review of Microbiology, 2016 Gram-negative and gram-positive bacteria use a variety of enzymatic pathways to degrade mRNAs. Although several recent reviews have outlined these pathways, much less attention has been paid to the regulation of mRNA decay. The functional half-life of a particular mRNA, which affects how much protein is synthesized from it, is determined by a ...
B. Mohanty, S. R. Kushner
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The intricate balance between microRNA‐induced mRNA decay and translational repression
The FEBS Journal, 2022 Post‐transcriptional regulation of messenger RNAs (mRNAs) (i.e., mechanisms that control translation, stability and localization) is a critical focal point in spatiotemporal regulation of gene expression in response to changes in environmental conditions.
Parisa Naeli +4 more
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Regulation of gene expression in trypanosomatids: living with polycistronic transcription [PDF]
Open Biology, 2019 In trypanosomes, RNA polymerase II transcription is polycistronic and individual mRNAs are excised by trans-splicing and polyadenylation. The lack of individual gene transcription control is compensated by control of mRNA processing, translation and ...
Christine Clayton
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Nonsense-Mediated mRNA Decay, a Finely Regulated Mechanism
Biomedicines, 2022 Nonsense-mediated mRNA decay (NMD) is both a mechanism for rapidly eliminating mRNAs carrying a premature termination codon and a pathway that regulates many genes.
F. Lejeune
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The contribution of RNA decay quantitative trait loci to inter-individual variation in steady-state gene expression levels. [PDF]
PLoS Genetics, 2012 Recent gene expression QTL (eQTL) mapping studies have provided considerable insight into the genetic basis for inter-individual regulatory variation. However, a limitation of all eQTL studies to date, which have used measurements of steady-state gene ...
Athma A Pai +11 more
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Complex degradation processes lead to non-exponential decay patterns and age-dependent decay rates of messenger RNA. [PDF]
PLoS ONE, 2013 Experimental studies on mRNA stability have established several, qualitatively distinct decay patterns for the amount of mRNA within the living cell.
Carlus Deneke +2 more
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