Results 201 to 210 of about 1,826,338 (237)

When mRNA translation meets decay

Biochemical Society Transactions, 2017
Messenger RNA (mRNA) translation and mRNA degradation are important determinants of protein output, and they are interconnected. Previously, it was thought that translation of an mRNA, as a rule, prevents its degradation. mRNA surveillance mechanisms, which degrade mRNAs as a consequence of their translation, were considered to be exceptions to this ...
Bicknell, Alicia A., Ricci, Emiliano P.
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CYP3A5 mRNA Degradation by Nonsense-Mediated mRNA Decay

Molecular Pharmacology, 2005
The total CYP3A5 mRNA level is significantly greater in carriers of the CYP3A5*1 allele than in CYP3A5*3 homozygotes. Most of the CYP3A5*3 mRNA includes an intronic sequence (exon 3B) containing premature termination codons (PTCs) between exons 3 and 4.
Florent, Busi, Thierry, Cresteil
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Mechanisms of mRNA decay

Trends in Biotechnology, 1990
• Clarifying complementary roles for natural and genetically manipu- lated microorganisms. • Assuring that bioremediation does not produce toxic inter- mediates or hazardous end products in treated environments. • Broadening the range of priority chemicals treatable by biological processes.
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Shutdown decay of mRNA

Molecular Microbiology, 2006
SummaryAlthough plasmid‐borne and chromosomal toxin–antitoxin (TA) operons have been known for some time, the recent identification of mRNA as the target of at least two different classes of toxins has led to a dramatic renewal of interest in these systems as mediators of stress responses.
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Measuring mRNA Decay with Roadblock‐qPCR

Current Protocols, 2022
AbstractThe control of mRNA stability is fundamental to gene regulation, and a deeper understanding of this post‐transcriptional regulatory step can provide key insights into gene function. Measuring mRNA half‐lives directly, however, is challenging.
Maegan J, Watson, Carson C, Thoreen
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Mechanistic Modeling of Prokaryotic mRNA Decay

Journal of Theoretical Biology, 1997
A mechanistic model of gene expression was developed to test three prevailing and sliding prokaryotic mRNA decay theories: ribosome protection of mRNA from endonucleases, 5' binding and sliding of endonucleases on mRNA, and hybrid 5' binding/ribosome protection.
T A, Carrier, J D, Keasling
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Regulation of nonsense‐mediated mRNA decay

WIREs RNA, 2012
AbstractNonsense‐mediated mRNA decay (NMD) is a highly conserved pathway that was originally identified as a RNA surveillance mechanism that degrades aberrant mRNAs harboring premature termination (nonsense) codons. Recently, it was discovered that NMD also regulates normal gene expression.
Lulu, Huang, Miles F, Wilkinson
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Nonsense-mediated mRNA decay (NMD) mechanisms

Nature Structural & Molecular Biology, 2009
Nonsense-mediated mRNA decay (NMD) is a translation-coupled mechanism that eliminates mRNAs containing premature translation-termination codons (PTCs). In mammalian cells, NMD is also linked to pre-mRNA splicing, as in many instances strong mRNA reduction occurs only when the PTC is located upstream of an intron.
Saverio, Brogna, Jikai, Wen
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Analyzing mRNA decay in saccharomyces cerevisiae

2002
Publisher Summary This chapter discusses the process of mRNA decay in Saccharomyces cerevisiae ( S. cerevisiae ) and describes the experimental procedures that can be used to determine the rates of mRNA turnover in yeast, as well as the specific pathway of degradation for any given transcript.
Michelle A, Steiger, Roy, Parker
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Gene silencing by microRNAs: contributions of translational repression and mRNA decay

Nature reviews genetics, 2011
Eric Huntzinger, E. Izaurralde
semanticscholar   +1 more source