Results 31 to 40 of about 1,826,338 (237)

Staufen‐mediated mRNA decay [PDF]

WIREs RNA, 2013
Staufen1 (STAU1)‐mediated mRNA decay (SMD) is an mRNA degradation process in mammalian cells that is mediated by the binding of STAU1 to a STAU1‐binding site (SBS) within the 3′‐untranslated region (3′‐UTR) of target mRNAs. During SMD, STAU1, a double‐stranded (ds) RNA‐binding protein, recognizes dsRNA structures formed either by intramolecular base ...
Eonyoung, Park, Lynne E, Maquat
openaire   +2 more sources

Direct measurement of transcription rates reveals multiple mechanisms for configuration of the Arabidopsis ambient temperature response [PDF]

, 2014
Background Sensing and responding to ambient temperature is important for controlling growth and development of many organisms, in part by regulating mRNA levels.
Costa, Maria J. (Maria João), Finkenstädt, Bärbel, Penfield, Steven, Rand, D. A. (David A.), Sidaway-Lee, Kate   +4 more
core   +1 more source

Non-invasive measurement of mRNA decay reveals translation initiation as the major determinant of mRNA stability

eLife, 2018
The cytoplasmic abundance of mRNAs is strictly controlled through a balance of production and degradation. Whereas the control of mRNA synthesis through transcription has been well characterized, less is known about the regulation of mRNA turnover, and a
Leon Y Chan, Christopher F Mugler, Stephanie Heinrich, Pascal Vallotton, Karsten Weis   +4 more
doaj   +1 more source

Cytoplasmic mRNA decay represses RNA polymerase II transcription during early apoptosis

eLife, 2021
RNA abundance is generally sensitive to perturbations in decay and synthesis rates, but crosstalk between RNA polymerase II transcription and cytoplasmic mRNA degradation often leads to compensatory changes in gene expression.
Christopher Duncan-Lewis, Ella Hartenian, Valeria King, Britt A Glaunsinger   +3 more
doaj   +1 more source

Post-transcriptional regulation of satellite cell quiescence by TTP-mediated mRNA decay. [PDF]

, 2015
Skeletal muscle satellite cells in their niche are quiescent and upon muscle injury, exit quiescence, proliferate to repair muscle tissue, and self-renew to replenish the satellite cell population.
Blackshear, Perry J, Cadwallader, Adam B, Clement, Sandra L, Doles, Jason D, Hall, Monica N, Hausburg, Melissa A, Lykke-Andersen, Jens, Olwin, Bradley B   +7 more
core   +2 more sources

Codon optimality and mRNA decay [PDF]

Cell Research, 2016
Recent evidence indicates that codon optimality is a broad determinant of mRNA stability. A study by Radhakrishnan et al. in Cell raises the possibility that the conserved DEAD-box protein Dhh1 underlies the phenomenon.
Yuriko, Harigaya, Roy, Parker
openaire   +2 more sources

The eIF4E-Binding Protein 4E-T Is a Component of the mRNA Decay Machinery that Bridges the 5′ and 3′ Termini of Target mRNAs

Cell Reports, 2015
Eukaryotic mRNA degradation often initiates with the recruitment of the CCR4-NOT deadenylase complex and decay factors to the mRNA 3′ terminus. How the 3′-proximal decay machinery interacts with the 5′-terminal cap structure in order to engender mRNA ...
Tamiko Nishimura, Zoya Padamsi, Hana Fakim, Simon Milette, Wade H. Dunham, Anne-Claude Gingras, Marc R. Fabian   +6 more
doaj   +1 more source

A self-organized model for cell-differentiation based on variations of molecular decay rates [PDF]

, 2012
Systemic properties of living cells are the result of molecular dynamics governed by so-called genetic regulatory networks (GRN). These networks capture all possible features of cells and are responsible for the immense levels of adaptation ...
A Bhattacharjya, A Bossi, A Ciechanover, A Hoffmann, A Visel, AC Gavin, AP Capaldi, AU Viretta, B de Chassey, B Schwanhäusser, CC Guet, CG Langton, D Bratsun, D Das, D Ropers, D Stokić, EL Greer, EM Ozbudak, G Yagil, GM Church, H de Jong, H Kitano, I Shmulevich, J Gertz, J Gsponer, J Paulsson, JE Lee, JH Park, L Glass, L Glass, L Hood, L Pirkkala, M Mitchell, M Ptashne, M Rewieński, MA Beer, Manfred Pöchacker, Manuel Schölling, MB Burg, MJ Amorim, N Kashtan, NM Luscombe, P Smolen, Peter Csermely, R Casey, R Hanel, R Jothi, R Métivier, R Métivier, RP Zinzen, Rudolf Hanel, S Pigolotti, S Semsey, SA Kauffman, SA Vokes, Stefan Thurner, TE Turner, TI Lee, TR Burkard, X Qian, Z Tothova   +60 more
core   +4 more sources

Viral Manipulation of Host Mrna Decay [PDF]

Future Virology, 2018
Viruses alter host-cell gene expression at many biochemical levels, such as transcription, translation, mRNA splicing and mRNA decay in order to create a cellular environment suitable for viral replication. In this review, we discuss mechanisms by which viruses manipulate host-gene expression at the level of mRNA decay in order to enable the virus to ...
Liang, Guo, Irina, Vlasova-St Louis, Paul R, Bohjanen   +2 more
openaire   +2 more sources

Stochastic Modeling of Expression Kinetics Identifies Messenger Half-Lives and Reveals Sequential Waves of Co-ordinated Transcription and Decay [PDF]

, 2012
The transcriptome in a cell is finely regulated by a large number of molecular mechanisms able to control the balance between mRNA production and degradation. Recent experimental findings have evidenced that fine and specific regulation of degradation is
Cacace, Filippo, Cusimano, Valerio, FARINA, Lorenzo, Germani, Alfredo, PACI, PAOLA   +4 more
core   +3 more sources