Results 51 to 60 of about 1,826,338 (237)
Molecules and Cells, 2019 The maternal-to-zygotic transition (MZT) is a conserved and fundamental process during which the maternal environment is converted to an environment of embryonic-driven development through dramatic reprogramming.
Ying Yang +25 more
semanticscholar +1 more source
A career in (mRNA) decay [PDF]
RNA, 2015 My entry into the RNA world began in 1967 when a visiting lecturer at the University of Toronto, the late Dr. Gordon Tener, inspired my interest in RNA. Various aspects of RNA biology, from ribosomes to plant viruses, occupied my attention during the early stages of my career.
openaire +2 more sources
Journal of Lipid Research, 1995 To better understand the accelerated decay of fatty acid synthase (FAS) message that occurs after glucose deprivation (J. Biol. Chem. 1993. 268: 6961-6970), we characterized the 3‘ terminus of the human message and the kinetics of FAS mRNA decay in HepG2
C F Semenkovich +2 more
doaj +1 more source
The impact of nonsense-mediated mRNA decay on genetic disease, gene editing and cancer immunotherapy
Nature Genetics, 2019 Premature termination codons (PTCs) can result in the production of truncated proteins or the degradation of messenger RNAs by nonsense-mediated mRNA decay (NMD).
Rik G. H. Lindeboom +3 more
semanticscholar +1 more source
Suppressing nonsense--a surprising function for 5-azacytidine. [PDF]
, 2014 In this issue of EMBO Molecular Medicine, Bhuvanagiri et al report on a chemical means to convert molecular junk into gold. They identify a chemical inhibitor of a quality control pathway that is best known for its ability to clear cells of rubbish, but ...
Shao, Ada, Wilkinson, Miles F
core +2 more sources
UPFront and center in RNA decay: UPF1 in nonsense-mediated mRNA decay and beyond
RNA: A publication of the RNA Society, 2019 Nonsense-mediated mRNA decay (NMD), which is arguably the best-characterized translation-dependent regulatory pathway in mammals, selectively degrades mRNAs as a means of post-transcriptional gene control.
Yoon Ki Kim, L. Maquat
semanticscholar +1 more source
Interaction of yeast eIF4G with spliceosome components Implications in pre-mRNA processing events [PDF]
, 2009 International audienceAs evidenced from mammalian cells the eukaryotic translation initiation factor eIF4G has a putative role in nuclear RNA metabolism. Here we investigate whether this role is conserved in the yeast Saccharomyces cerevisiae.
Barrass, J. David +6 more
core +2 more sources
The CAF1-NOT complex of trypanosomes
Frontiers in Genetics, 2014 In African trypanosomes, there is no control of transcription initiation by RNA polymerase II at the level of individual protein-coding genes. Transcription is polycistronic, and individual mRNAs are excised by trans splicing and polyadenylation.
Esteban eErben +2 more
doaj +1 more source
Identification of novel post-transcriptional features in olfactory receptor family mRNAs. [PDF]
, 2015 Olfactory receptor (Olfr) genes comprise the largest gene family in mice. Despite their importance in olfaction, how most Olfr mRNAs are regulated remains unexplored.
Espinoza, Josh L +3 more
core +1 more source
The rules and impact of nonsense-mediated mRNA decay in human cancers
Nature Genetics, 2016 Premature termination codons (PTCs) cause a large proportion of inherited human genetic diseases. PTC-containing transcripts can be degraded by an mRNA surveillance pathway termed nonsense-mediated mRNA decay (NMD). However, the efficiency of NMD varies;
Rik G. H. Lindeboom +2 more
semanticscholar +1 more source