Results 61 to 70 of about 1,826,338 (237)

New insights into no-go, non-stop and nonsense-mediated mRNA decay complexes.

Current Opinion in Structural Biology, 2020
Eukaryotes possess a variety of translational control mechanisms which function in the surveillance of mRNAs, discriminating between normal and aberrant translation elongation and termination, triggering mRNA decay.
K. T. Powers, Jenn-Yeu A Szeto, C. Schaffitzel   +2 more
semanticscholar   +1 more source

Promoter Elements Regulate Cytoplasmic mRNA Decay [PDF]

Cell, 2011
Promoters are DNA elements that enable transcription and its regulation by trans-acting factors. Here, we demonstrate that yeast promoters can also regulate mRNA decay after the mRNA leaves the nucleus. A conventional yeast promoter consists of a core element and an upstream activating sequence (UAS).
Bregman, Almog, Avraham-Kelbert, Moran, Barkai, Oren, Duek, Lea, Guterman, Adi, Choder, Mordechai   +5 more
openaire   +2 more sources

Cotranslational microRNA mediated messenger RNA destabilization

eLife, 2016
MicroRNAs are small (22 nucleotide) regulatory molecules that play important roles in a wide variety of biological processes. These RNAs, which bind to targeted mRNAs via limited base pairing interactions, act to reduce protein production from those ...
Trinh To Tat, Patricia A Maroney, Sangpen Chamnongpol, Jeff Coller, Timothy W Nilsen   +4 more
doaj   +1 more source

Nonsense-Mediated mRNA Decay Begins Where Translation Ends.

Cold Spring Harbor Perspectives in Biology, 2018
Nonsense-mediated mRNA decay (NMD) is arguably the best-studied eukaryotic messenger RNA (mRNA) surveillance pathway, yet fundamental questions concerning the molecular mechanism of target RNA selection remain unsolved.
E. Karousis, O. Mühlemann
semanticscholar   +1 more source

Tristetraprolin Mediates Interferon-γ mRNA Decay [PDF]

Journal of Biological Chemistry, 2009
Tristetraprolin (TTP) regulates expression at the level of mRNA decay of several cytokines, including the T cell-specific cytokine, interleukin-2. We performed experiments to determine whether another T cell-specific cytokine, interferon-gamma (IFN-gamma), is also regulated by TTP and found that T cell receptor-activated T cells from TTP knock-out mice
Rachel L, Ogilvie, Julius R, Sternjohn, Bernd, Rattenbacher, Irina A, Vlasova, Darlisha A, Williams, Heidi H, Hau, Perry J, Blackshear, Paul R, Bohjanen   +7 more
openaire   +2 more sources

Full UPF3B function is critical for neuronal differentiation of neural stem cells [PDF]

, 2015
Acknowledgments We thank Fred H Gage (Salk Institute, La Jolla, CA, USA) for HCN-A94 cells and Niels Gehring (University of Cologne, Germany) for constructs.
Alrahbeni, Tahani, Anderson, Jihan, McCaig, Colin, Miedzybrodzka, Zosia, Muller, Berndt, Sartor, Francesca   +5 more
core   +2 more sources

Nonsense‐mediated mRNA decay: The challenge of telling right from wrong in a complex transcriptome

Wiley Interdisciplinary Reviews - RNA, 2019
The nonsense‐mediated mRNA decay pathway selects and degrades its targets using a dense network of RNA‐protein and protein–protein interactions. Together, these interactions allow the pathway to collect copious information about the translating mRNA ...
Aparna Kishor, Sarah E. Fritz, J. Hogg
semanticscholar   +1 more source

Nuclear Decay Factors Crack Up mRNA [PDF]

Molecular Cell, 2017
In this issue of Molecular Cell, Bresson et al. (2017) show that the nuclear RNA decay factors Nab3 and Mtr4 reshape the coding transcriptome during glucose starvation in budding yeast, placing nuclear mRNA metabolism as an important contributor of gene expression regulation.
Agnieszka Tudek, Manfred Schmid, Torben Heick Jensen   +2 more
openaire   +3 more sources

Apoptosis Triggers Specific, Rapid, and Global mRNA Decay with 3′ Uridylated Intermediates Degraded by DIS3L2

Cell Reports, 2015
Apoptosis is a tightly coordinated cell death program that damages mitochondria, DNA, proteins, and membrane lipids. Little is known about the fate of RNA as cells die.
Marshall P. Thomas, Xing Liu, Jennifer Whangbo, Geoffrey McCrossan, Keri B. Sanborn, Emre Basar, Michael Walch, Judy Lieberman   +7 more
doaj   +1 more source

A novel class of microRNA-recognition elements that function only within open reading frames. [PDF]

, 2018
MicroRNAs (miRNAs) are well known to target 3' untranslated regions (3' UTRs) in mRNAs, thereby silencing gene expression at the post-transcriptional level.
A Aizer, A Helwak, A Jakymiw, A Lal, AE Pasquinelli, AJ Giraldez, Alexander Dobin, AM Duursma, AR Buskirk, AR Quinlan, B Langmead, Bing Zhou, CJ Decker, CJ Shoemaker, CJ Woolstenhulme, CP Petersen, Dehe Wang, DP Bartel, DT Humphreys, E Huntzinger, EL Nostrand Van, GB Loeb, Guangqiao Liu, H Guo, HA Meijer, HO Iwakawa, I Behm-Ansmant, I Elcheva, J Hausser, J Liu, J Liu, JH Kim, Jie Zhou, JJ Forman, JP Broughton, K Seggerson, KA O’Donnell, Kai Zhang, L Wu, Ligang Wu, M Hafner, M Kouwenhove van, M Rehmsmeier, MD Robinson, MK Doma, ML Donnelly, N Rajewsky, NT Schirle, PA Maroney, Qian Zhao, R Ishimura, R Ishimura, R Parker, Ran Cao, RS Pillai, S Bagga, S Djuranovic, S Grosswendt, S Gu, S Jonas, S Nottrott, S Takagi, SN Bhattacharyya, SW Chi, SW Eichhorn, Timothy Nilsen, TT Tat, V Presnyak, W Filipowicz, Wen Ruan, X Adiconis, Xiang-Dong Fu, Xiaorong Zhang, Y Ishigaki, Y Liao, Y Tay, Y Wang, Y Xue, Y Zhao, Ya Zhao, Yan Qin, Yu Zhou, Yuanchao Xue, Z Cai, Zhiqiang Cai, Zonggui Chen   +85 more
core   +2 more sources