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Pharmaceutical strategies for optimized mRNA expression
BiomaterialsMessenger RNA (mRNA)-based immunotherapies and protein in situ production therapies hold great promise for addressing theoretically all the diseases characterized by aberrant protein levels. The safe, stable, and precise delivery of mRNA to target cells via appropriate pharmaceutical strategies is a prerequisite for its optimal efficacy. In this review,
Yingying Shi +5 more
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Canadian Journal of Physiology and Pharmacology, 2005
Chunghyuldan (CHD), a combinatorial drug that has antihyperlipidemic and anti-inflammatory activities, has been shown to improve arterial stiffness and inhibit stroke recurrence in clinical study. To understand the molecular basis of CHD's clinical effects, we explored its effect on cell proliferation and expression of nitric oxide synthase (NOS) and ...
Seong-Uk, Park +7 more
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Chunghyuldan (CHD), a combinatorial drug that has antihyperlipidemic and anti-inflammatory activities, has been shown to improve arterial stiffness and inhibit stroke recurrence in clinical study. To understand the molecular basis of CHD's clinical effects, we explored its effect on cell proliferation and expression of nitric oxide synthase (NOS) and ...
Seong-Uk, Park +7 more
openaire +2 more sources
The Cerebellum, 2008
Friedreich's ataxia is an autosomal recessive neurodegenerative disease that is due to the loss of function of the frataxin protein. The molecular basis of this disease is still a matter of debate and treatments have so far focused on managing symptoms. Drugs that can increase the amount of frataxin protein offer a possible therapy for the disease. One
ACQUAVIVA, Fabio +8 more
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Friedreich's ataxia is an autosomal recessive neurodegenerative disease that is due to the loss of function of the frataxin protein. The molecular basis of this disease is still a matter of debate and treatments have so far focused on managing symptoms. Drugs that can increase the amount of frataxin protein offer a possible therapy for the disease. One
ACQUAVIVA, Fabio +8 more
openaire +4 more sources
TGF-β1 mRNA expression in clinical breast cancer and its relationship to ER mRNA expression
Breast Cancer Research and Treatment, 1997Eighty nine primary breast cancers were investigated for the expression of TGF-beta 1 and ER mRNA using PCR of reverse transcribed RNA. PCR products were validated using Southern blots and hybridization with radiolabelled cDNA probes. TGF beta 1 mRNA was found to be expressed in 56/89 (63%) of the breast cancers while ER mRNA was expressed in 23/89 (26%
K D, Amoils, W R, Bezwoda
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Identification of novel mRNAs expressed in oligodendrocytes
Neurochemical Research, 1994To identify new proteins, which are expressed in oligodendrocytes and which may have a functional role in myelination, a rat oligodendrocyte cDNA library was screened using differential and subtractive screening techniques. Ten clones that have elevated levels of expression in brain were isolated.
H, Baba +4 more
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Increased trkB mRNA expression by axotomized motoneurones
NeuroReport, 1994It has been previously demonstrated that members of the neurotrophin family may prevent death of motoneurones following axotomy. Here we report that the expression of mRNA for full-length trkB, which is a signal transducing receptor for BDNF and NT-4, increases transiently in spinal motoneurones after axotomy in adult rats.
F, Piehl +4 more
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Selective chemokine mRNA expression following brain injury
Brain Research, 1998Injury in non-neuronal tissues stimulates chemokine expression leading to recruitment of inflammatory cells responsible for orchestration of repair processes. The signals involved in directing repair of damage to the brain are less well understood. We hypothesized that following brain injury, chemokines are expressed and regulate the rate and pattern ...
E H, Hausmann +5 more
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Differential Display of Expressed mRNAs
1997Biological responses to processes including stimulation with growth factors or cell differentiation depend on changes in the expression of the 50000–100000 genes that are encoded in the genomes of higher eukaryotes. Therefore, it is important that the technology used for monitoring changes in gene expression is able to detect quantitative and ...
M. Jørgensen +7 more
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A novel mRNA expressed along brain ventricles
Gene Expression Patterns, 2002The present descriptive study shows the expression pattern of an mRNA, IIIG9, whose most striking expression is seen along the lining of all four ventricles of the adult rat brain. Lower levels of expression are evident in other areas of the brain, notably in cortex, hippocampus, and various thalamic, hypothalamic and brainstem nuclei where it seems to
Patria E, Danielson +4 more
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Antioxidant regulation of gene expression: Analysis of differentially expressed mRNAs
1999Publisher Summary Progress in genome sciences has led to the development of sensitive and rapid techniques for DNA sequencing. These techniques, combined with improved application of the techniques for total RNA and mRNA isolations, amplification of DNA fragments by polymerase chain reaction (PCR), and the techniques for comprehensive analysis of ...
K, Gohil, S, Roy, L, Packer, C K, Sen
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