eIF4E orchestrates mRNA processing, RNA export and translation to modify specific protein production [PDF]
NucleusThe eukaryotic translation initiation factor eIF4E acts as a multifunctional factor that simultaneously influences mRNA processing, export, and translation in many organisms.
Jean-Clément Mars +2 more
doaj +3 more sources
The trypanocidal benzoxaborole AN7973 inhibits trypanosome mRNA processing. [PDF]
PLoS Pathogens, 2018 Kinetoplastid parasites-trypanosomes and leishmanias-infect millions of humans and cause economically devastating diseases of livestock, and the few existing drugs have serious deficiencies.
Daniela Begolo +11 more
doaj +5 more sources
Parvovirus RNA Processing: Compact Genomic Organization and Unique Alternative mRNA Processing Mechanisms [PDF]
VirusesParvoviruses have compact genomic organizations with overlapping open reading frames and thus utilize alternative RNA processing strategies, alternative splicing, alternative polyadenylation, and alternative translation mechanisms to generate a range of ...
Lisa K. Uhl, Olufemi O. Fasina
doaj +3 more sources
Aging Alters mRNA Processing in the Mouse Ovary [PDF]
CellsAging in females affects the ovaries before any other organ. This has a significant impact on women’s health. Aging results in the gradual depletion of ovarian follicles and a decline in oocyte quality.
Kevin Vo +4 more
doaj +4 more sources
Kaposi’s Sarcoma-Associated Herpesvirus ORF57 Protein: Exploiting All Stages of Viral mRNA Processing [PDF]
Viruses, 2013 Nuclear mRNA export is a highly complex and regulated process in cells. Cellular transcripts must undergo successful maturation processes, including splicing, 5'-, and 3'-end processing, which are essential for assembly of an export competent ...
Adrian Whitehouse +3 more
doaj +6 more sources
Nanopore direct RNA sequencing maps the complexity of Arabidopsis mRNA processing and m6A modification [PDF]
eLife, 2020 Understanding genome organization and gene regulation requires insight into RNA transcription, processing and modification. We adapted nanopore direct RNA sequencing to examine RNA from a wild-type accession of the model plant Arabidopsis thaliana and a ...
Barton, Geoffrey J. +8 more
core +4 more sources
In vivo nuclear RNA structurome reveals RNA-structure regulation of mRNA processing in plants
Genome Biology, 2021 Background mRNA processing is critical for gene expression. A challenge in regulating mRNA processing is how to recognize the actual mRNA processing sites, such as splice and polyadenylation sites, when the sequence content is insufficient for this ...
Zhenshan Liu +8 more
doaj +2 more sources
Oncogenic dysregulation of pre-mRNA processing by protein kinases: challenges and therapeutic opportunities. [PDF]
FEBS J, 2021 Alternative splicing and polyadenylation represent two major steps in pre‐mRNA‐processing, which ensure proper gene expression and diversification of human transcriptomes.
Naro C, Bielli P, Sette C.
europepmc +2 more sources
Pre-mRNA Processing Factors and Retinitis Pigmentosa: RNA Splicing and Beyond. [PDF]
Front Cell Dev Biol, 2021 Retinitis pigmentosa (RP) is the most common inherited retinal disease characterized by progressive degeneration of photoreceptors and/or retinal pigment epithelium that eventually results in blindness. Mutations in pre-mRNA processing factors (PRPF3, 4,
Yang C +10 more
europepmc +2 more sources
Assembly and regulation of the mammalian mRNA processing body. [PDF]
PLoS ONE, 2023 Messenger RNA processing bodies (P-bodies) are cytoplasmic membrane-free organelles that contain proteins involved in mRNA silencing, storage and decay.
Donald B Bloch +3 more
doaj +3 more sources