Assembly and regulation of the mammalian mRNA processing body. [PDF]
PLoS ONE, 2023 Messenger RNA processing bodies (P-bodies) are cytoplasmic membrane-free organelles that contain proteins involved in mRNA silencing, storage and decay.
Donald B Bloch +3 more
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Parvovirus RNA Processing: Compact Genomic Organization and Unique Alternative mRNA Processing Mechanisms [PDF]
VirusesParvoviruses have compact genomic organizations with overlapping open reading frames and thus utilize alternative RNA processing strategies, alternative splicing, alternative polyadenylation, and alternative translation mechanisms to generate a range of ...
Lisa K. Uhl, Olufemi O. Fasina
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Aging Alters mRNA Processing in the Mouse Ovary [PDF]
CellsAging in females affects the ovaries before any other organ. This has a significant impact on women’s health. Aging results in the gradual depletion of ovarian follicles and a decline in oocyte quality.
Kevin Vo +4 more
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Replicative aging in yeast involves dynamic intron retention patterns associated with mRNA processing/export and protein ubiquitination [PDF]
Microbial CellSaccharomyces cerevisiae (baker´s yeast) has yielded relevant in-sights into some of the basic mechanisms of organismal aging. Among these are genomic instability, oxidative stress, caloric restriction and mitochondrial dysfunction.
Jesús Gómez-Montalvo +4 more
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Mitochondrial mRNA Processing in the Chlorophyte Alga Pediastrum duplex and Streptophyte Alga Chara vulgaris Reveals an Evolutionary Branch in Mitochondrial mRNA Processing [PDF]
Plants, 2021 Mitochondria carry the remnant of an ancestral bacterial chromosome and express those genes with a system separate and distinct from the nucleus. Mitochondrial genes are transcribed as poly-cistronic primary transcripts which are post-transcriptionally ...
Grayson C. R. Proulex +3 more
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Clinically relevant benzoxaboroles inhibit mRNA processing in Trypanosoma brucei [PDF]
BMC Research Notes, 2022 Objective The cleavage and polyadenylation endonuclease CPSF73 is thought to be the target of the anti-trypanosomal benzoxaboroles AN7973, acoziborole and AN11736. We previously showed that AN7973 inhibits mRNA processing.
Albina Waithaka, Christine Clayton
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eIF4E orchestrates mRNA processing, RNA export and translation to modify specific protein production [PDF]
NucleusThe eukaryotic translation initiation factor eIF4E acts as a multifunctional factor that simultaneously influences mRNA processing, export, and translation in many organisms.
Jean-Clément Mars +2 more
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Kaposi’s Sarcoma-Associated Herpesvirus ORF57 Protein: Exploiting All Stages of Viral mRNA Processing [PDF]
Viruses, 2013 Nuclear mRNA export is a highly complex and regulated process in cells. Cellular transcripts must undergo successful maturation processes, including splicing, 5'-, and 3'-end processing, which are essential for assembly of an export competent ...
Adrian Whitehouse +3 more
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In vivo nuclear RNA structurome reveals RNA-structure regulation of mRNA processing in plants [PDF]
Genome Biology, 2021 Background mRNA processing is critical for gene expression. A challenge in regulating mRNA processing is how to recognize the actual mRNA processing sites, such as splice and polyadenylation sites, when the sequence content is insufficient for this ...
Zhenshan Liu +8 more
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Aberrant pre-mRNA processing in cancer. [PDF]
J Exp MedDysregulation of the flow of information from genomic DNA to RNA to protein occurs within all cancer types. In this review, we described the current state of understanding of how RNA processing is dysregulated in cancer with a focus on mutations in the RNA splicing factor machinery that are highly prevalent in hematologic malignancies.
Biswas J +3 more
europepmc +3 more sources