PABPN1-Dependent mRNA Processing Induces Muscle Wasting. [PDF]
PLoS Genetics, 2016 Poly(A) Binding Protein Nuclear 1 (PABPN1) is a multifunctional regulator of mRNA processing, and its expression levels specifically decline in aging muscles. An expansion mutation in PABPN1 is the genetic cause of oculopharyngeal muscle dystrophy (OPMD),
Muhammad Riaz +6 more
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Genome Biology, 2018 Background The multifaceted control of gene expression requires tight coordination of regulatory mechanisms at transcriptional and post-transcriptional level.
Seyed Yahya Anvar +11 more
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Clinically relevant benzoxaboroles inhibit mRNA processing in Trypanosoma brucei [PDF]
BMC Research Notes, 2022 Objective The cleavage and polyadenylation endonuclease CPSF73 is thought to be the target of the anti-trypanosomal benzoxaboroles AN7973, acoziborole and AN11736. We previously showed that AN7973 inhibits mRNA processing.
Albina Waithaka, Christine Clayton
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Mitochondrial mRNA Processing in the Chlorophyte Alga Pediastrum duplex and Streptophyte Alga Chara vulgaris Reveals an Evolutionary Branch in Mitochondrial mRNA Processing [PDF]
Plants, 2021 Mitochondria carry the remnant of an ancestral bacterial chromosome and express those genes with a system separate and distinct from the nucleus. Mitochondrial genes are transcribed as poly-cistronic primary transcripts which are post-transcriptionally ...
Grayson C. R. Proulex +3 more
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Replicative aging in yeast involves dynamic intron retention patterns associated with mRNA processing/export and protein ubiquitination [PDF]
Microbial CellSaccharomyces cerevisiae (baker´s yeast) has yielded relevant in-sights into some of the basic mechanisms of organismal aging. Among these are genomic instability, oxidative stress, caloric restriction and mitochondrial dysfunction.
Jesús Gómez-Montalvo +4 more
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Ovule identity mediated by pre-mRNA processing in Arabidopsis. [PDF]
PLoS Genetics, 2018 Ovules are fundamental for plant reproduction and crop yield as they are the precursors of seeds. Therefore, ovule specification is a critical developmental program. In Arabidopsis thaliana, ovule identity is redundantly conferred by the homeotic D-class
Encarnación Rodríguez-Cazorla +7 more
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Pseudouridine synthases modify human pre-mRNA co-transcriptionally and affect pre-mRNA processing. [PDF]
Mol Cell, 2022 Martinez NM +7 more
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RNA methylation in nuclear pre‐mRNA processing [PDF]
WIREs RNA, 2018 Eukaryotic RNA can carry more than 100 different types of chemical modifications. Early studies have been focused on modifications of highly abundant RNA, such as ribosomal RNA and transfer RNA, but recent technical advances have made it possible to also
Helena Covelo-Molares +2 more
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Multipurpose RNA maturation factors dysregulate multiple mRNA processing steps simultaneously and provide new therapeutic opportunities [PDF]
RNA BiologymRNAs undergo a series of chemical modifications to become competent for nuclear export and translation. This is referred to as mRNA maturation or processing and includes capping, splicing, and 3’end formation.
Sunirmal Paira, Katherine L. B. Borden
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Pre-mRNA processing factors meet the DNA damage response
Frontiers in Genetics, 2013 It is well known that DNA damaging agents induce genome instability, but only recently have we begun to appreciate that chromosomes are fragile per se and frequently subject to DNA breakage.
Alessandra eMontecucco +1 more
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