Results 11 to 20 of about 18,476,439 (363)
Nanopore direct RNA sequencing maps the complexity of Arabidopsis mRNA processing and m6A modification [PDF]
eLife, 2020 Understanding genome organization and gene regulation requires insight into RNA transcription, processing and modification. We adapted nanopore direct RNA sequencing to examine RNA from a wild-type accession of the model plant Arabidopsis thaliana and a ...
Barton, Geoffrey J. +8 more
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PABPN1-Dependent mRNA Processing Induces Muscle Wasting. [PDF]
PLoS Genetics, 2016 Poly(A) Binding Protein Nuclear 1 (PABPN1) is a multifunctional regulator of mRNA processing, and its expression levels specifically decline in aging muscles. An expansion mutation in PABPN1 is the genetic cause of oculopharyngeal muscle dystrophy (OPMD),
Muhammad Riaz +6 more
doaj +2 more sources
Genome Biology, 2018 Background The multifaceted control of gene expression requires tight coordination of regulatory mechanisms at transcriptional and post-transcriptional level.
Seyed Yahya Anvar +11 more
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Integrating mRNA Processing with Transcription [PDF]
Cell, 2002 The messenger RNA processing reactions of capping, splicing, and polyadenylation occur cotranscriptionally. They not only influence one another's efficiency and specificity, but are also coordinated by transcription. The phosphorylated CTD of RNA polymerase II provides key molecular contacts with these mRNA processing reactions throughout ...
Proudfoot, N, Furger, A, Dye, M
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Ovule identity mediated by pre-mRNA processing in Arabidopsis. [PDF]
PLoS Genetics, 2018 Ovules are fundamental for plant reproduction and crop yield as they are the precursors of seeds. Therefore, ovule specification is a critical developmental program. In Arabidopsis thaliana, ovule identity is redundantly conferred by the homeotic D-class
Encarnación Rodríguez-Cazorla +7 more
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The trypanocidal benzoxaborole AN7973 inhibits trypanosome mRNA processing.
PLoS Pathogens, 2018 Kinetoplastid parasites-trypanosomes and leishmanias-infect millions of humans and cause economically devastating diseases of livestock, and the few existing drugs have serious deficiencies.
Daniela Begolo +11 more
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RNA methylation in nuclear pre‐mRNA processing [PDF]
WIREs RNA, 2018 Eukaryotic RNA can carry more than 100 different types of chemical modifications. Early studies have been focused on modifications of highly abundant RNA, such as ribosomal RNA and transfer RNA, but recent technical advances have made it possible to also study messenger RNA (mRNA).
Covelo‐Molares, Helena +2 more
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Multipurpose RNA maturation factors dysregulate multiple mRNA processing steps simultaneously and provide new therapeutic opportunities [PDF]
RNA BiologymRNAs undergo a series of chemical modifications to become competent for nuclear export and translation. This is referred to as mRNA maturation or processing and includes capping, splicing, and 3’end formation.
Sunirmal Paira, Katherine L. B. Borden
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Roles of Sumoylation in mRNA Processing and Metabolism [PDF]
Advances in Experimental Medicine and Biology, 2017 SUMO has gained prominence as a regulator in a number of cellular processes. The roles of sumoylation in RNA metabolism, however, while considerable, remain less well understood. In this chapter we have assembled data from proteomic analyses, localization studies and key functional studies to extend SUMO's role to the area of mRNA processing and ...
Vasupradha Vethantham +2 more
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Pre-mRNA processing factors meet the DNA damage response
Frontiers in Genetics, 2013 It is well known that DNA damaging agents induce genome instability, but only recently have we begun to appreciate that chromosomes are fragile per se and frequently subject to DNA breakage.
Alessandra eMontecucco +1 more
doaj +2 more sources