Regulation of SUMOylation on RNA metabolism in cancers
Frontiers in Molecular Biosciences, 2023 Post-translational modifications of proteins play very important roles in regulating RNA metabolism and affect many biological pathways. Here we mainly summarize the crucial functions of small ubiquitin-like modifier (SUMO) modification in RNA metabolism
Yingting Cao +3 more
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Nutritional Regulation of mRNA Processing [PDF]
The Journal of Nutrition, 2004 Understanding how a cell adapts to dietary energy in the form of carbohydrate versus energy in the form of triacylglycerol requires knowledge of how the activity of the enzymes involved in lipogenesis is regulated. Changes in the activity of these enzymes are largely caused by changes in the rate at which their proteins are synthesized.
Wioletta Szeszel-Fedorowicz +6 more
openaire +3 more sources
Regulation of pre-mRNA processing by src [PDF]
Current Biology, 1995 Changes in gene expression in response to external signals provide a key mechanisms for the regulation of higher eukaryotic cell functions. The importance of transcriptional control in the response of cells to growth factors and cytokines has been extensively documented, but gene expression has also been shown to be controlled at other levels, such as ...
Neel, Henry +3 more
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U2 snRNP is required for expression of the 3' end of genes. [PDF]
PLoS ONE, 2014 Pre-mRNA in eukaryotes is subjected to mRNA processing, which includes capping, polyadenylation, and splicing. Transcription and mRNA processing are coupled, and this coupling stimulates mRNA processing; however, the effects of mRNA processing on ...
Mitsunori Koga +5 more
doaj +1 more source
A snoRNA modulates mRNA 3' end processing and regulates the expression of a subset of mRNAs. [PDF]
, 2017 mRNA 3' end processing is an essential step in gene expression. It is well established that canonical eukaryotic pre-mRNA 3' processing is carried out within a macromolecular machinery consisting of dozens of trans-acting proteins. However, it is unknown
Ding, Junjun +14 more
core +1 more source
Muscle-specific splicing factors ASD-2 and SUP-12 cooperatively switch alternative pre-mRNA processing patterns of the ADF/cofilin gene in Caenorhabditis elegans. [PDF]
PLoS Genetics, 2012 Pre-mRNAs are often processed in complex patterns in tissue-specific manners to produce a variety of protein isoforms from single genes. However, mechanisms orchestrating the processing of the entire transcript are not well understood.
Genta Ohno +6 more
doaj +1 more source
Regulated Inositol‐Requiring Protein 1‐Dependent Decay as a Mechanism of Corin RNA and Protein Deficiency in Advanced Human Systolic Heart Failure [PDF]
, 2014 BACKGROUND: The compensatory actions of the endogenous natriuretic peptide system require adequate processing of natriuretic peptide pro‐hormones into biologically active, carboxyl‐terminal fragments.
Barton, P +5 more
core +1 more source
Alternative Polyadenylation in Human Diseases [PDF]
Endocrinology and Metabolism, 2017 Varying length of messenger RNA (mRNA) 3′-untranslated region is generated by alternating the usage of polyadenylation sites during pre-mRNA processing.
Jae-Woong Chang +2 more
doaj +1 more source
A conformational RNA zipper promotes intron ejection during non-conventional XBP1 mRNA splicing. [PDF]
, 2015 The kinase/endonuclease IRE1 is the most conserved signal transducer of the unfolded protein response (UPR), an intracellular signaling network that monitors and regulates the protein folding capacity of the endoplasmic reticulum (ER).
Acosta-Alvear, Diego +3 more
core +1 more source
MENGA: a new comprehensive tool for the integration of neuroimaging data and the Allen human brain transcriptome atlas [PDF]
, 2016 Brain-wide mRNA mappings offer a great potential for neuroscience research as they can provide information about system proteomics. In a previous work we have correlated mRNA maps with the binding patterns of radioligands targeting specific molecular ...
Bertoldo, A +4 more
core +8 more sources