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mRNA STABILITY AND CELLULAR DIFFERENTIATION
Acta Endocrinologica, 1972ABSTRACT The diversity of mRNA half-lives was investigated in a differentiated insect tissue, the silkmoth galea, which is specialized for production of a characteristic protein, the zymogen of the proteolytic enzyme, cocoonase. It appears that the differentiation-specific cocoonase mRNA is uniquely stable (half-life ca. 100 h).
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Estradiol regulates estrogen receptor mRNA stability
The Journal of Steroid Biochemistry and Molecular Biology, 1998Previous studies suggest that post-transcriptional events play an important role in estrogen-induced loss of estrogen receptor expression. The present study shows that treatment of MCF-7 cells with estradiol resulted in a six-fold decrease in estrogen receptor mRNA half-life from 4 h in control cells to 40 min in estradiol treated cells.
M, Saceda +4 more
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5′-Terminal structure and mRNA stability
Nature, 1977Reovirus mRNAs with 5'terminal m7GpppGm or GpppG are more stable than mRNA containing unblocked ppG 5'-ends when injected into Xenopus laevis oocytes or incubated in cell-free protein synthesising extracts of wheat germ and mouse L cells. The greater stability of mRNA with blocked 5' termini is not dependent upon translation but seems to result from ...
Y, Furuichi, A, LaFiandra, A J, Shatkin
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Hypoxia-Induced Regulation of mRNA Stability
2002Because molecular oxygen is essential for generating cellular energy in aerobic organisms, and because survival depends on this fundamental requirement for oxygen, all higher organisms have evolved numerous diversely regulated mechanisms to detect and respond to potentially life-threatening occurrences of decreased oxygen availability (hypoxia).
W R, Paulding, M F, Czyzyk-Krzeska
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Chaperone Directs mRNA Stability
Science's STKE, 2007Heat-shock cognate protein 70 (HSC70) is a multifunctional protein that has known functions as an adenosine triphosphatase (ATPase) in the uncoating of clathrin-coated vesicles and in the facilitation of protein folding. Matsui et al . provide evidence that this versatile protein also serves to regulate stability of
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Control of mRNA stability in eukaryotes
Biochemical Society Transactions, 2006mRNA turnover plays a key role in the control of gene expression. Recent work has shown that proteins involved in mRNA turnover are located in multicomponent complexes which are tightly regulated. The control of mRNA stability is also intimately linked with translational processes.
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1992
Abstract The level of an mRNA in the cell is determined both by its rate of synthesis and by its rate of decay. Since mRNA half-lives range from about 1 min to over 1 h in the yeast, Saccharomyces cerevisiae (1–4), differential rates of mRNA decay have a fundamental influence upon the overall pattern of protein synthesis in this model
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Abstract The level of an mRNA in the cell is determined both by its rate of synthesis and by its rate of decay. Since mRNA half-lives range from about 1 min to over 1 h in the yeast, Saccharomyces cerevisiae (1–4), differential rates of mRNA decay have a fundamental influence upon the overall pattern of protein synthesis in this model
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Stability and degradation of mRNA
2015This chapter focuses on the stability and degradation of mRNA, highlighting other classes of RNA molecules that have regulated half-lives. It talks about regulating the stability of mRNA which provides another means of controlling gene expression. The chapter also clarifies that protein molecules can be synthesized if an mRNA is more stable.
David Elliott, Michael Ladomery
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