Results 21 to 30 of about 199,785 (356)
Advanced Drug Delivery Reviews, 2021 mRNA vaccines have evolved from being a mere curiosity to emerging as COVID-19 vaccine front-runners. Recent advancements in the field of RNA technology, vaccinology, and nanotechnology have generated interest in delivering safe and effective mRNA therapeutics. In this review, we discuss design and self-assembly of mRNA vaccines.
Kim, Jeonghwan +3 more
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Emergence of mRNA vaccines in the management of cancer
Expert Review of Vaccines, 2023 Introduction mRNA vaccines have been developed as a promising cancer management. It is noted that specification of the antigen sequence of the target antigen is necessary for the design and manufacture of an mRNA vaccine. Areas covered The steps involved
Mohamad Irfan Mohamad Razif +8 more
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Journal of Genetics and Genomics, 2021 The ongoing COVID-19 pandemic and its unprecedented global societal and economic disruptive impact highlight the urgent need for safe and effective vaccines. Taking substantial advantages of versatility and rapid development, two mRNA vaccines against COVID-19 have completed late-stage clinical assessment at an unprecedented speed and reported positive
Huang, Qingrui +2 more
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Efficient mRNA Delivery with mRNA Lipoplexes Prepared Using a Modified Ethanol Injection Method
Pharmaceutics, 2023 Messenger RNA (mRNA)-based therapies are a novel class of therapeutics used in vaccination and protein replacement therapies for monogenic diseases.
Min Tang +5 more
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Industrial Psychiatry Journal, 2021 “Necessity is the mother of invention:” An adage was brought to life with the emergence of the mRNA vaccine against the backdrop of the foreboding and mercurial COVID-19 pandemic. Considering a negligible adverse-effect profile and a break-neck manufacturing speed, it shone bright as the ideal vaccine candidate.
Tahoora Ali +4 more
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From mRNA sensing to vaccines [PDF]
Immunity, 2021 The 2005 Immunity paper by Karikó et al. has been hailed as a cornerstone insight that directly led to the design and delivery of the mRNA vaccines against COVID-19. We asked experts in pathogen sensing, vaccine development, and public health to provide their perspective on the study and its implications.
Fauci, Anthony S. +8 more
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Vaccines, 2023 Previous studies have shown that the herpes zoster subunit vaccine Shingrix™ performs well in clinical trials. However, the key ingredient in its adjuvant, QS21, is extracted from rare plants in South America, so vaccine production is limited.
Kangyang Lin +5 more
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Developing mRNA-vaccine technologies [PDF]
RNA Biology, 2012 mRNA vaccines combine desirable immunological properties with an outstanding safety profile and the unmet flexibility of genetic vaccines. Based on in situ protein expression, mRNA vaccines are capable of inducing a balanced immune response comprising both cellular and humoral immunity while not subject to MHC haplotype restriction.
Thomas, Schlake +3 more
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Vaccines, 2022 The advent of the Omicron variant globally has hastened the requirement for a booster vaccination dose to confer continuous protection against symptomatic SARS-CoV2 infection.
Biyan Zhang +8 more
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mRNA as a Therapeutics: Understanding mRNA Vaccines
Advanced Pharmaceutical Bulletin, 2021 Vaccination is one of the important approaches in the prevention and control of diseases. Although the capacity to present antigens other than the disease-specific antigen in the traditional vaccine composition provides a potential benefit by increasing its protective efficacy, many components that are not needed for the related disease are also ...
Ferdi Oguz, Harika Atmaca
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