Results 81 to 90 of about 199,785 (356)

A lipid-based LMP2-mRNA vaccine to treat nasopharyngeal carcinoma [PDF]

, 2023
Miusi Shi, Xing Duan, Xingchen Peng, Zhaohui Jin, Hai Huang, Wen Xiao, Qian Zheng, Yongqi Deng, Na Fan, Kepan Chen, Xiangrong Song   +10 more
openalex   +1 more source

mRNA Innovates the Vaccine Field [PDF]

Vaccines, 2021
Development of new vaccine modalities is a critical need to address many of the shortcomings of traditional platforms such as the lack of sufficient efficacy against certain pathogens or cancer; difficulties with production; or, in some cases, safety issues [...]
openaire   +3 more sources

Lipid Nanoparticles for the Delivery of CRISPR/Cas9 Machinery to Enable Site‐Specific Integration of CFTR and Mutation‐Agnostic Disease Rescue

Advanced Functional Materials, EarlyView.
Lipid nanoparticles (LNPs) are optimized to co‐deliver Cas9‐encoding messenger RNA (mRNA), a single guide RNA (sgRNA) targeting the endogenous cystic fibrosis transmembrane conductance regulator (CFTR) gene, and homologous linear double‐stranded donor DNA (ldsDNA) templates encoding CFTR.
Ruth A. Foley, Paul G. Ayoub, Vrishti Sinha, Colin Juett, Alicia Sanoyca, Emily C. Duggan, Lindsay E. Lathrop, Priyanka Bhatt, Kevin Coote, Beate Illek, Brigitte N. Gomperts, Donald B. Kohn, Steven J. Jonas   +12 more
wiley   +1 more source

Single self-cleaving mRNA vaccine expressing multiple viral structural proteins elicits robust immune responses and protects nursing piglets against PDCoV infection

Journal of Virology
As an emerging swine enteric coronavirus, porcine deltacoronavirus (PDCoV) poses a severe threat to the global swine industry and has demonstrated potential for cross-species transmission.
Ruiming Yu, Yingjie Bai, Liping Zhang, Peng Zhou, Zhongwang Zhang, Jun Yang, Yanzhen Lu, Dongsheng Wang, Yousheng Peng, Dan Li, Jian He, Yonglu Wang, Quanwei Zhang, Ligang Yuan, Huichen Guo, Li Pan, Xinsheng Liu   +16 more
doaj   +1 more source

Transcriptome analysis of Taenia solium cysticerci using Open reading Frame ESTS (ORESTES) [PDF]

, 2009
Background Human infection by the pork tapeworm Taenia solium affects more than 50 million people worldwide, particularly in underdeveloped and developing countries. Cysticercosis which arises from larval encystation can be life threatening and difficult
Almeida, Carolina R., Bayer-Santos, Ethel, Davila, Alberto M. R., Dias-Neto, Emmanuel, Ferreira, Henrique B., Grisard, Edmundo C., Maia, Antônio A., Ojopi, Elida P. B., Rodrigues, Juliana B., Rotava, Gianinna, Sincero, Thaís C. M., Sperandio, Maísa M., Stoco, Patricia H., Tyler, Kevin M., Wagner, Glauber, Zaha, Arnaldo   +15 more
core   +3 more sources

Expanding Chemical Space of Nucleic Acid Nanoparticles for Tunable Antiviral‐Like Immunomodulatory Responses and Potent Adjuvant Activity

Advanced Functional Materials, EarlyView.
We introduce a nucleic acid nanoparticle (NANP) platform designed to be rrecognized by the human innate immune system in a regulated manner. By changing chemical composition while maintaining constant architectural parameters, we identify key determinants of immunorecognition enabling the rational design of NANPs with tunable immune activation profiles
Martin Panigaj, Hannah S. Newton, Jian Wang, Laxmi Pandey, Yelixza I. Avilla, Phong Nguyen, Morgan Chandler, Justin Halman, Yasmine Radwan, Stephanie Smith, Elijah Edmondson, Simone Difilippantonio, Chelsea Sanders, Bao Tran, Yongmei Zhao, Shaojun Xie, Edward Cedrone, Barry W. Neun, Meni Wanunu, Nikolay V. Dokholyan, Marina A. Dobrovolskaia, Kirill A. Afonin   +21 more
wiley   +1 more source

Challenges and Scientific Prospects of the Newest Generation of mRNA-Based Vaccines against SARS-CoV-2

Life, 2021
In the context of the current COVID-19 pandemic, traditional, complex and lengthy methods of vaccine development and production would not have been able to ensure proper management of this global public health crisis. Hence, a number of technologies have
Daniela Calina, Antonio F. Hernández, Thomas Hartung, Alexey M. Egorov, Boris Nikolaevich Izotov, Taxiarchis Konstantinos Nikolouzakis, Aristidis Tsatsakis, Panayiotis G. Vlachoyiannopoulos, Anca Oana Docea   +8 more
doaj   +1 more source

Immunogenicity of SARS‐CoV‐2 mRNA vaccine in solid organ transplant recipients [PDF]

, 2021
Inge K. Holden, Claus Bistrup, Anna Christine Nilsson, Janne Fuglsang Hansen, Rozeta Abazi, Jesper Rømhild Davidsen, Mikael Kjær Poulsen, Susan Olaf Lindvig, Ulrik Stenz Justesen, Işık Somuncu Johansen   +9 more
openalex   +1 more source

Liquid Crystalline Inverted Lipid Phases and Reverse Micelles in Drug Delivery: From Molecular Design to Therapeutic Potential

Advanced Functional Materials, EarlyView.
Liquid crystalline inverted lipid phases and reverse micelles are self‐assembled lipid nanostructures that enhance the solubility, stability, and delivery of diverse therapeutics. This review integrates their physicochemical principles, formulation strategies, drug loading mechanisms, and biomedical applications, highlighting their growing ...
Numan Eczacioglu, Mulazim Hussain Asim, Soheil Haddadzadegan, Andreas Bernkop‐Schnürch   +3 more
wiley   +1 more source

Development of an Influenza/COVID-19 Combination mRNA Vaccine Containing a Novel Multivalent Antigen Design That Enhances Immunogenicity of Influenza Virus B Hemagglutinins

Vaccines
Background/Objectives: Developing next-generation mRNA-based seasonal influenza vaccines remains challenging, primarily because of the relatively low immunogenicity of influenza B hemagglutinin (HA) antigens.
Elena Thornhill-Wadolowski, Dana L. Ruter, Feng Yan, Mayur Gajera, Evan Kurt, Labannya Samanta, Kimberlin Leigh, Jianbo Zhu, Zhijun Guo, Zihao Wang, Yuanqing Liu, Jaewoo Lee, Marcin Bugno   +12 more
doaj   +1 more source