Results 161 to 170 of about 110,071 (192)
Some of the next articles are maybe not open access.
Innate sensing of mRNA vaccines
Current Opinion in Immunology, 2022With the recent success of mRNA vaccines and the approval of several RNA oligonucleotide therapeutics, RNA holds great promise for future drug development. The rise of RNA therapeutics has been enabled by the tremendous progress in our understanding of the sophisticated cellular mechanisms that disarm potentially dangerous exogenous RNA and safeguard ...
Christine, Wuebben +2 more
openaire +2 more sources
2016
mRNA cancer vaccines are a relatively new class of vaccines, which combine the potential of mRNA to encode for almost any protein with an excellent safety profile and a flexible production process. The most straightforward use of mRNA vaccines in oncologic settings is the immunization of patients with mRNA vaccines encoding tumor-associated antigens ...
Katja, Fiedler +4 more
openaire +2 more sources
mRNA cancer vaccines are a relatively new class of vaccines, which combine the potential of mRNA to encode for almost any protein with an excellent safety profile and a flexible production process. The most straightforward use of mRNA vaccines in oncologic settings is the immunization of patients with mRNA vaccines encoding tumor-associated antigens ...
Katja, Fiedler +4 more
openaire +2 more sources
The tangled history of mRNA vaccines
Nature, 2021Hundreds of scientists had worked on mRNA vaccines for decades before the coronavirus pandemic brought a breakthrough. Hundreds of scientists had worked on mRNA vaccines for decades before the coronavirus pandemic brought a breakthrough.
openaire +2 more sources
Nanotechnology-based mRNA vaccines
Nature Reviews Methods Primers, 2023mRNA vaccines have emerged as a revolutionary tool to generate rapid and precise immune responses against infectious diseases and cancers. Compared with conventional vaccines such as inactivated viruses, viral vectors, protein subunits or DNA-based vaccines, mRNA vaccines stand out owing to multiple advantages, including simplicity of design, fast ...
Shuying Chen +9 more
openaire +2 more sources
Recent innovations in mRNA vaccines
Current Opinion in Immunology, 2016Nucleic acid-based vaccines are being developed as a means to combine the positive attributes of both live-attenuated and subunit vaccines. Viral vectors and plasmid DNA vaccines have been extensively evaluated in human clinical trials and have been shown to be safe and immunogenic, although none have yet been licensed for human use.
Jeffrey B Ulmer, Andrew J Geall
openaire +2 more sources
Adjuvant-Enhanced mRNA Vaccines
2016Recent advances in molecular biology have led to dramatic enhancement of the stability of in vitro transcribed (IVT) messenger RNA (mRNA) and improvement in its translational efficacy. Nowadays, mRNA-based vaccines represent a promising approach in the field of anticancer immunotherapy, gaining attention over the earlier-established bacteria-, virus ...
Bialkowski, Lukasz +7 more
openaire +2 more sources
Computational design of mRNA vaccines
VaccinemRNA technology has emerged as a successful vaccine platform that offered a swift response to the COVID-19 pandemic. Accumulating evidence shows that vaccine efficacy, thermostability, and other important properties, are largely impacted by intrinsic properties of the mRNA molecule, such as RNA sequence and structure, both of which can be optimized ...
Yoo-Ah, Kim +9 more
openaire +2 more sources
mRNA vaccines in the rheumatologist's future
Seminars in Arthritis and RheumatismVaccines taking advantage of mRNA technology have been long in development.To review the status of approved mRNA vaccines for infectious diseases as well as those in development.Systematic literature review of clinical and immunologic studies of mRNA vaccines against infectious diseases.Currently approved mRNA vaccines include those against SARS CoV-2 ...
openaire +2 more sources
mRNA vaccines for infectious diseases: principles, delivery and clinical translation
Nature Reviews Drug Discovery, 2021Namit Chaudhary +2 more
exaly