Results 201 to 210 of about 162,270 (298)

Impact of pre-existing anti-replicase immunity on the efficacy of self-amplifying mRNA vaccines. [PDF]

Nat Commun
Cui X, Amelinck L, Gillon O, Catani JPP, Gao Y, Sun Q, De Sutter E, Vervaeke P, Snoeck J, Lienenklaus S, Saelens X, Zhong Z, Sanders NN.   +12 more
europepmc   +1 more source

Who Will Protect the Children?

Annals of the Child Neurology Society, EarlyView.
William D. Graf, Leon G. Epstein
wiley   +1 more source

Identification of Clinical Factors Associated With the Immunogenicity of Homologous ChAdOx1‐nCoV‐19 Vaccine in Hemodialysis Patients

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Hemodialysis (HD) patients are at higher risk of severe COVID‐19 and may exhibit suboptimal vaccine responses. This study evaluates the factors influencing vaccine‐induced immunity in HD patients following the second dose of the Vaxzevria. A total of 276 HD patients and 126 controls were included. Antibody responses were assessed using binding
Chia‐Wei Chang, Ping‐Hsun Wu, Li‐Yun Chang, Yu‐Ying Huang, Teng‐Hui Huang, Su‐Chu Lee, Yi‐wen Chiu, Shang‐Jyh Hwang, Tsun‐Yung Kuo, Mei‐Chuan Kuo   +9 more
wiley   +1 more source

Next-Generation mRNA Vaccines in Melanoma: Advances in Delivery and Combination Strategies. [PDF]

Cells
Zoroddu S, Bagella L.
europepmc   +1 more source

The generation of tumor vaccines by adenovirus-enhanced transfection of cytokine genes into tumor cells [PDF]

, 1994
Berger, M., Birnstiel, Max L., Buschle, M., Cotten, Matt, Maass, Gerd, Schmidt, Walter, Skouteris, George G., Wagner, Ernst, Zatloukal, Kurt   +8 more
core   +1 more source

Polyglycerol‐Based Lipids: A Next‐Generation Alternative to PEG in Lipid Nanoparticles for Advanced Drug Delivery Systems

Macromolecular Rapid Communications, EarlyView.
Linear polyglycerol is proposed as a PEG‐alternative in mRNA‐loaded lipid nanoparticles to limit activation of anti‐PEG antibodies and reduce immunogenicity. Resulting nanoparticles may provide similar gene delivery capabilities, while preventing binding of anti‐PEG antibodies compared to PEGylated counterparts.
Yara Ensminger, Rashmi Rashmi, Michael Karimov, Gideon Nölte, Markus Hafke, Ann‐Cathrin Schmitt, David Díaz‐Oviedo, Johannes Köbberling, Rainer Haag   +8 more
wiley   +1 more source

SARS-CoV-2 mRNA vaccines sensitize tumours to immune checkpoint blockade. [PDF]

Nature
Grippin AJ, Marconi C, Copling S, Li N, Braun C, Woody C, Young E, Gupta P, Wang M, Wu A, Jeong SD, Soni D, Weidert F, Xie C, Goldenberg E, Kim A, Zhao C, DeVries A, Castillo P, Lohray R, Rooney MK, Schrank BR, Wang Y, Ma Y, Chang E, Kouzy R, Dyson K, Jafarnia J, Nariman N, Gladish G, New J, Argueta A, Amaya D, Thomas N, Doty A, Chen J, Copling N, Alatrash G, Simon J, Davies AB, Dennis W, Liang R, Lewis J, Wei X, Rinsurongkawong W, Vaporciyan AA, Johns A, D3CODE Team, Lee J, Lee JH, Sun R, Sharma P, Tran H, Zhang J, Gibbons DL, Wargo J, Kim BYS, Heymach JV, Mendez-Gomez HR, Jiang W, Sayour EJ, Lin SH.   +61 more
europepmc   +1 more source

Poly(sarcosine) Lipid Synthesis From CO2‐Based Sarcosine‐N‐Carboxyanhydride

Macromolecular Rapid Communications, EarlyView.
In this work, we optimize and scale‐up a CO2‐based synthesis of sarcosine‐N‐carboxyanhydride (Sar‐NCA) to the gram scale. The low toxicity and simplicity of the approach make it an attractive alternative to current toxic phosgene‐based approaches. The CO2‐based Sar‐NCA has sufficient purity for controlled polymerization.
Florian T. Kaps, Leon Quellmalz, Annika D. S. Richardson, Anna‐Lena Ziegler, Sarah Moreau, Susanne K. Wiedmer, Timo Repo, Robert Luxenhofer   +7 more
wiley   +1 more source

Preparation and Immunological Efficacy Evaluation of mRNA Vaccines Targeting the Spike Protein of Bovine Coronavirus. [PDF]

Vaccines (Basel)
Liu S, Gong Z, Wang P, Chen F, Fu X, Fan H, Li Y, Han X, Chen J, Zhang L, Xue L, Bai H, Liu S, Huang L, Du W, Lin A, Xia J.   +16 more
europepmc   +1 more source

Machine Learning for Predictive Modeling in Nanomedicine‐Based Cancer Drug Delivery

Med Research, EarlyView.
The integration of AI/ML into nanomedicine offers a transformative approach to therapeutic design and optimization. Unlike conventional empirical methods, AI/ML models (such as classification, regression, and neural networks) enable the analysis of complex clinical and formulation datasets to predict optimal nanoparticle characteristics and therapeutic
Rohan Chand Sahu, Sanchit Arora, Dinesh Kumar, Ashish Kumar Agrawal   +3 more
wiley   +1 more source