Results 221 to 230 of about 162,270 (298)

Balancing allocative and dynamic efficiency with redundant R&D allocation: The role of organizational proximity and centralization

Strategic Management Journal, EarlyView.
Abstract Research Summary Resource‐based‐view scholars have mainly examined two resource allocation approaches for competitive advantage in multiunit firms: resource sharing and resource redeployment. These approaches emphasize allocative efficiency—the optimal allocation of resources to maximize their current value. In technology‐intensive industries,
Vivek Tandon, Anand Nandkumar, Ronak Mogra, Kannan Srikanth   +3 more
wiley   +1 more source

Systematic analysis of COVID-19 mRNA vaccines using four orthogonal approaches demonstrates no excessive DNA impurities. [PDF]

NPJ Vaccines
Achs A, Sedlackova T, Predajna L, Budis J, Bartosova M, Zelnik V, Rusnakova D, Melichercikova M, Miklosova M, Gencurova V, Cernakova B, Szemes T, Klempa B, Kopacek J, Pastorekova S.   +14 more
europepmc   +1 more source

Nature Inspired Delivery Vehicles for CRISPR‐Based Genome Editing

Small, EarlyView.
The review highlights nature‐inspired nanocarriers for CRISPR delivery, emphasizing viral vectors, extracellular vesicles, liposomes, and lipid nanoparticles. It discusses their roles in improving specificity, minimizing immunogenicity, and overcoming barriers in genome editing. Recent advancements, challenges, and therapeutic applications are explored,
Elizabeth Maria Clarissa, Mamata Karmacharya, Hyunmin Choi, Sumit Kumar, Yoon‐Kyoung Cho   +4 more
wiley   +1 more source

Intranasal mRNA vaccines: Targeting mucosal immunity through optimized delivery. [PDF]

Mol Ther Nucleic Acids
Pandey A, Kumar S, Mishra S.
europepmc   +1 more source

Nasal Delivery of mRNA Using Thermoresponsive Gellable Aqueous Biphasic Systems

Small, EarlyView.
Nasal delivery of mRNA using gellable aqueous biphasic systems (ABS) represents a noninvasive alternative while reducing the need for trained professionals and cold chain storage. Composed of gelatin, PEG, and water, these thermoresponsive hydrogels ensure controlled mRNA delivery and prolonged retention at the nasal mucosa, improving transfection ...
Bojan Kopilovic, Nabila Laroui, João A.P. Coutinho, Chantal Pichon, Mara G. Freire   +4 more
wiley   +1 more source

mRNA vaccines and SiRNAs targeting cancer immunotherapy: challenges and opportunities. [PDF]

Discov Oncol
Lv Z, Dai Y.
europepmc   +1 more source

From Membrane Composition to Antimicrobial Strategies: Experimental and Computational Approaches to AMP Design and Selectivity

Small, EarlyView.
Antimicrobial peptides (AMPs) are promising candidates for next‐generation antibiotics, acting through mechanisms such as membrane disruption and intracellular targeting. This review examines how variations in bacterial membrane composition critically influence AMP activity.
Paolo Rossetti, Marius F.W. Trollmann, Christina Wichmann, Thomas Gutsmann, Christian Eggeling, Rainer A. Böckmann   +5 more
wiley   +1 more source

The Future of mRNA Vaccines: Potential Beyond COVID-19. [PDF]

Cureus
Saxena S, Mandrah V, Tariq W, Das P, Sambhav K, Devi SH.   +5 more
europepmc   +1 more source

Decoding pH‐Driven Phase Transition of Lipid Nanoparticles

Small, EarlyView.
Ionizable aminolipids govern lipid nanoparticle (LNP) function through environment‐dependent protonation. Constant‐pH molecular dynamics reveal intrinsic, apparent, and surface pKa${\rm pK}_{\text{a}}$ values within LNP‐mimetic membranes, demonstrating that the LNP lipid environment induces a pronounced downward pKa${\rm pK}_{\text{a}}$ shift exceeding
Marius F.W. Trollmann, Rainer A. Böckmann   +1 more
wiley   +1 more source

Human CD4 T cells are a functional target for lipid nanoparticle-based mRNA vaccines. [PDF]

mBio
Kim SC, Felgner J, Soto MS, Hitchcock L, Silzel EK, Beares H, Hwang MJ, Yates TB, Cheng S, Joloya EM, Sureshchandra S, Sorn AM, Wagoner ZW, Tifrea D, Kabeer M, Trask D, Othy S, Felgner P, Wagar LE.   +18 more
europepmc   +1 more source