Results 231 to 240 of about 162,270 (298)

Impact of general anaesthesia on immune response to first rabies vaccination in seronegative domestic cats

Veterinary Record, EarlyView.
Abstract Background Despite common concerns, evidence that anaesthesia impairs vaccine efficacy remains limited. This study assessed the impact of general anaesthesia on the immune response to rabies vaccination in cats. Methods Thirty‐five healthy female cats (6–12 months old) undergoing elective spaying were enrolled.
Pierre Bessière, Romane Breysse, Marion Chrétien, Brandon Hayes, Séverine Boullier, Anouck Labadie, Jonathan Rieder, Marine Wasniewski, Géraldine Jourdan   +8 more
wiley   +1 more source

Potentiating the Efficacy of mRNA Vaccines through NIR-II Imaging-Guided Precise Vaccination. [PDF]

Adv Sci (Weinh)
Li M, Zheng X, Yu X, Qi S, Zhu S, Yu G, Zhang S.   +6 more
europepmc   +1 more source

Sphinganine‐phosphate prevents influenza infection via promoting CD8+ T cells proliferation and activation

VIEW, EarlyView.
This study established clinical cohorts of respiratory viral infections and identified sphinganine‐phosphate (SA) as a metabolite significantly upregulated post‐infection through metabolomic analysis. In vitro and in vivo experiments demonstrated that SA promotes the generation of effector CD8+ T cells via the SOCS1/JAK1/STAT1 pathway, which ...
Zhongwen Hu, Guiling Yan, Junhong Li, Yuan Yuan, Hong Zhang, Yuchao Zhong, Yuanyuan Peng, Wenjia Zhang, Xiaoyan Su, Changchun Niu, Yang Luo   +10 more
wiley   +1 more source

Potential of MRNA vaccines for mpox prevention: current evidence and future directions. [PDF]

Ann Med Surg (Lond)
Abdul-Rahman T, Faith OE, Ajetunmobi OA, Thaalibi HI, Ikele CG, Gautam G, Omotayo FO, Roy P, Adebayo AA, Mojeed MA, Kareem TT, Ali HI, Atieno RG, Ademeta EO, Garg N, Ashinze P, Scott GY.   +16 more
europepmc   +1 more source

Crystallographic fragment screening against SARS‐CoV‐2 nonstructural protein 1 using the F2X‐Entry Screen and a newly developed fragment library

Acta Crystallographica Section D, EarlyView.
Two crystallographic fragment screening campaigns against SARS‐CoV‐2 nonstructural protein 1 resulted in the identification of 21 new hits.Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) continues to threaten global health. This underpins the need for novel therapeutics against this virus.
Frank Lennartz, Jan Wollenhaupt, Melanie Oelker, Paula Fröling, Uwe Mueller, Anke Deckers, Christoph Grathwol, Stefan Bräse, Nicole Jung, Manfred S. Weiss   +9 more
wiley   +1 more source

Maltase 1 regulates DENV2 infection and life history in Aedes aegypti

Insect Science, EarlyView.
Our study employed CRISPR/Cas9 to generate a MAL1 knockout strain of Aedes aegypti, demonstrating that the absence of MAL1 significantly suppresses DENV2 replication in the midgut and impairs viral transmission. The mutation also altered life‐history (hatching/pupation/emerging rates and sex‐specific survival), identifying MAL1 as a novel target for ...
Man‐Jin Li, Jin Cheng, Ya‐Ming Zou, Quan‐Chao Liu, Ding Zhu, Ce‐Jie Lan   +5 more
wiley   +1 more source

Synergistic effect of nucleoside modification and ionizable lipid composition on translation and immune responses to mRNA vaccines. [PDF]

NPJ Vaccines
Danz H, Dauner A, Sharma S, Babiceanu M, Clark N, Ontiveros RJ, Amezquita R, Zhilin-Roth A, Reyes E, Khoo C, Gilbert K, Nadkarni J, Chaudhary O, Lee C, Kume A, Bahadoran A, Motwani M, Lu B, Zong W, Kettring A, Shumate A, Karve S, Dias A, Wu M, Gu X, Yan Y, Anderson DG, Schanen B, Chivukula S, DeRosa F.   +29 more
europepmc   +1 more source

Personalized Cancer Vaccines in the Clinical Trial Pipeline

Asia-Pacific Journal of Clinical Oncology, EarlyView.
This study analyzes the current landscape of personalized cancer vaccine clinical trials, highlighting trends in vaccine platforms, trial phases, and geographic distribution. Peptide and dendritic cell vaccines dominate early‐stage research, with promising immune responses observed in melanoma, glioblastoma, and urothelial cancer trials.
Liudmila Iamukova, Elena Alferova
wiley   +1 more source

mRNA vaccines as cancer therapies. [PDF]

Chin Med J (Engl)
Huang S, Que H, Wang M, Wei X.
europepmc   +1 more source