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Computational design of mRNA vaccines
VaccinemRNA technology has emerged as a successful vaccine platform that offered a swift response to the COVID-19 pandemic. Accumulating evidence shows that vaccine efficacy, thermostability, and other important properties, are largely impacted by intrinsic properties of the mRNA molecule, such as RNA sequence and structure, both of which can be optimized ...
Yoo-Ah, Kim +9 more
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Vaccination with Messenger RNA (mRNA)
2008Both DNA and mRNA can be used as vehicles for gene therapy. Because the immune system is naturally activated by foreign nucleic acids thanks to the presence of Toll-like Receptors (TLR) in endosomes (TLR3, 7, and 8 detect exogenous RNA, while TLR9 can detect exogenous DNA), the delivery of foreign nucleic acids usually induces an immune response ...
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mRNA vaccines for infectious diseases: principles, delivery and clinical translation
Nature Reviews Drug Discovery, 2021Namit Chaudhary, Kathryn A Whitehead
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Suppressing autoimmunity with mRNA vaccines
Nature Reviews Drug Discovery, 2021openaire +2 more sources
Immune correlates analysis of the mRNA-1273 COVID-19 vaccine efficacy clinical trial
Science, 2022Peter B Gilbert +2 more
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