Results 191 to 200 of about 4,616 (237)

MRONJ risk reduction pathway - 360 degree survey

British Dental Journal, 2017
Introduction Bisphosphonates and denosumab reduce the risk of skeletal events in some malignancies (for example, breast, myeloma). These drugs carry a significant risk of a difficult-to-manage side effect of medication related osteonecrosis of the jaw (MRONJ). Preventive dental screening and treatment reduces the incidence of MRONJ.
A, Muthukrishnan, S, Al-Ismail, G, Bertelli, P, Browne   +3 more
openaire   +2 more sources

Royal Jelly as a Therapeutic Intervention in Medication-Related Osteonecrosis of the Jaw (MRONJ): An Animal Model Study.

Journal of Oral Pathology & Medicine
BACKGROUND To evaluate the efficacy of royal jelly in managing experimentally created MRONJ model in rats. METHODS Sixty rats were randomly allocated into control, bisphosphonate (BP), royal jelly (RJ), Treatment, and Preventive groups.
C. Topan, S. Bilge, Ahmet Emin Demirbaş, G. Ağyüz, Ayca Kara   +4 more
semanticscholar   +1 more source

Intraoperative ICG NIF Imaging Defines Surgical Margin in MRONJ: A Prospective Observational Study

Oral Diseases
This study explored the feasibility and effectiveness of indocyanine green (ICG)–based near‐infrared fluorescence (NIF) imaging for localizing bone lesions associated with medication‐related osteonecrosis of the jaw (MRONJ) during surgical intervention.
Dashuang Zhi, Xinyi Zhang, Shuyun Wan, Sheng Chen, C. Xia, Guowen Sun, Y. Pu   +6 more
semanticscholar   +1 more source

Denosumab: a case of MRONJ with resolution

British Dental Journal, 2016
A patient was referred by a clinical oncologist regarding a non-healing area of bone in the lower jaw. The patient was taking denosumab (Prolia(®), Xgeva(®)) when they had a tooth extracted and the area failed to heal. Following suspension of the drug, the area healed with mucosal coverage.
C V, Lyttle, H, Patterson
openaire   +2 more sources

Osteoclast-Derived Exosomes Promote MRONJ via the VEGFR2-Caspase9 and Notch1-Hes1/Hey Signaling Pathways.

Oral Diseases
OBJECTIVE To elucidate the mechanism of medication-related osteonecrosis of the jaw (MRONJ), which is challenging to prevent and treat, to facilitate the development of precise prevention and treatment strategies.
Kun Zhang, Jiankang Zhang, Qizhang Wang, Jian Pan   +3 more
semanticscholar   +1 more source

Update MRONJ and perspectives of its treatment

Journal of Stomatology, Oral and Maxillofacial Surgery, 2017
Antiresorptive agents are widely used in catabolic bone diseases. Not only bisphosphonates but also new drugs like Denosumab may induce osteonecrosis of the jaw as a side effect. The present review describes the current effect mechanisms of commonly used antiresorptives, pathogenetic theories for the development of antiresorptive-related osteonecrosis ...
Voss, Pit Jacob, Poxleitner, Philipp, Schmelzeisen, Rainer, Stricker, Andres, Semper-Hogg, Wiebke   +4 more
openaire   +3 more sources

The Microbiological Background of Medication-Related Osteonecrosis of the Jaw (MRONJ): Clinical Evidence Based on Traditional Culture and Molecular Biological Detection Methods

Antibiotics
Background: Medication-related osteonecrosis of the jaw (MRONJ) is a common adverse event following antiresorptive treatment, leading to chronic inflammation and exposed, necrotic bone surfaces in the jawbone.
Zsanett Kövér, Márió Gajdács, Beáta Polgár, Dóra Szabó, Edit Urbán   +4 more
semanticscholar   +1 more source

Is medical therapy alone efficient for the management of Medication-related osteonecrosis of the jaw bones (MRONJ) in all stages?: a comparative single-center case-control study

BMC Oral Health
The management of medication-related osteonecrosis of the jaw (MRONJ) is challenging, and there is ongoing debate over whether medical or surgical treatment is the gold standard.
Busehan Bilgin, Ö. Özalp, M. Altay, A. Sindel   +3 more
semanticscholar   +1 more source

Awareness and Attitude Towards MRONJ Among Physicians Prescribing Antiresorptive Drugs: A Cross-Sectional Study

BMC Oral Health
MRONJ (Medication-Related Osteonecrosis of the Jaw) refers to a condition characterized by osteonecrosis of the jawbone associated with the use of certain medications.
Murat Mutlu, Serpil Altundogan, Ömer Faruk Kocamaz   +2 more
semanticscholar   +1 more source

Clinical and radiologic treatment outcomes of implant presence tirggered-MRONJ: Systematic review of literature.

Oral Diseases
BACKGROUND The present systematic review evaluated clinical and radiographic features and treatment outcomes of peri-implantitis-induced medication-related osteonecrosis of the jaws (Pi-MRONJ).
M. Nisi, Stefano Gennai, Filippo Graziani, Antonio Barone, R. Izzetti   +4 more
semanticscholar   +1 more source