Results 111 to 120 of about 42,200 (256)

Aging‐Derived Alterations in Genomic, Immune, and Metabolic Networks: Implications for Cancer Development and Therapy

MedComm – Oncology, Volume 5, Issue 1, March 2026.
Ageing acts as a double‐edged sword in cancer. In the elderly, open chromatin, immunosenescence, and chronic inflammation drive SASP (IL‐6, MMPs), MDSC accumulation and T‐cell suppression, fostering tumor‐promoting microenvironments and limited therapeutic benefit.
Qi Wang, Xue Sun, Xinhao Han, Xingda Zhang, Wenzheng Wang, Hongbin Wang, He Ren, Lina Gu   +7 more
wiley   +1 more source

Perspective on This Article from Characterization of New Founder Alu-Mediated Rearrangements in <i>MSH2</i> Gene Associated with a Lynch Syndrome Phenotype

, 2023
Lucía Pérez‐Cabornero, Ester Borrás Flores, Mar Infante Sanz, Eladio A. Velasco, Alberto Acedo Becares, Enrique Lastra Aras, Jorge Cuevas González, Marta Pineda Riu, Teresa Ramón y Cajal Asensio, Gabriel Capellá, Cristina Miner Pino, M. Durán   +11 more
openalex   +1 more source

Identification of BCL2L11 as a Candidate Gene for Hereditary Predisposition to Non‐Medullary Thyroid Cancer Using Familial Whole‐Exome‐Sequencing

Clinical Genetics, Volume 109, Issue 3, Page 458-469, March 2026.
Whole‐exome sequencing of five families with non‐medullary thyroid cancer revealed three candidate genes. Functional analyses confirmed BCL2L11 as a strong candidate gene for hereditary predisposition to non‐medullary thyroid cancer. ABSTRACT Familial non‐medullary thyroid cancer, defined as two or more affected first‐degree relatives, accounts for 3 ...
Duygu Abbasoglu, Mathis Lepage, Nicolas Sonnier, Sandrine Viala, Nancy Uhrhammer, Flora Ponelle‐Chachuat, Anne Cayre, Maud Privat, Mathias Cavaillé, Yannick Bidet   +9 more
wiley   +1 more source

CHARACTERISTICS OF INDIVIDUALS UNDERGOING PANEL GENETIC TESTING FOR PRIMARY BRAIN TUMORS [PDF]

, 2018
Background. Currently, there are no genetic testing guidelines for patients with a primary brain tumor (PBT). This population is largely understudied in terms of the family history, tumor grade, pathology, and their relation to genetic contribution.
Azam, Sarah
core   +1 more source

Remote delivery of cancer genetic testing in veterans with metastatic prostate cancer: A Million Veteran Program pilot study

Cancer, Volume 132, Issue 3, 1 February 2026.
Abstract Background Germline pathogenic variants can inform targeted therapy for metastatic prostate cancer (mPC), and improve cancer early detection and risk reduction for family members. Guidelines recommend germline genetic testing be offered to all men with mPC, yet uptake of testing is only 10%–12%. Methods This prospective study enrolled veterans
Bruce Montgomery, Julie A. Lynch, Jessica Brown, Kara N. Maxwell, Craig C. Teerlink, Nismeta Kabilovic, Katie Stoll, Julie Simon, Maria Kogan, Sajida Hassan, Stacey B. Whitbourne, Sumitra Muralidhar, Martin W. Schoen, Rachel Ramoni, J. Michael Gaziano, Alexandra O. Sokolova, Heather H. Cheng, Ruth Etzioni, Colin C. Pritchard   +18 more
wiley   +1 more source

Correlation of MLH1 and MSH2 levels with clinicopathologic characteristics in colorectal cancer. [PDF]

, 2023
Ling T. Guo, Zhaohui Yu, Qin Li, Xiaohu Liang, Lindong Yang   +4 more
openalex  

2022-RA-1479-ESGO Sex hormone receptor expression, MSH2 and MSH6 loss, but not β-catenin nuclear translocation, is concordant between synchronous endometrial and ovarian carcinomas [PDF]

, 2022
Emily Southworth, Ian Croy, Michael Churchman, Charlie Gourley, C. Simon Herrington   +4 more
openalex   +1 more source

Cytological Features of Pancreatic Medullary Carcinoma Diagnosed by Endoscopic Ultrasound‐Guided Fine Needle Aspiration

Diagnostic Cytopathology, Volume 54, Issue 2, Page E54-E58, February 2026.
ABSTRACT Pancreatic medullary carcinoma is an extremely rare tumor classified as a histological subtype of pancreatic ductal adenocarcinoma. We report a case of a pancreatic medullary carcinoma and describe its cytological features. A 75‐year‐old woman presented with lower back pain, epigastric discomfort, and a tumor‐like lesion in the pancreatic body.
Urara Okawa, Keishi Mizuguchi, Miyu Okuda, Tatsuya Mori, Hiroko Ikeda   +4 more
wiley   +1 more source

Exploring the principles of logotherapy in genetic counseling: Enhancing decision‐making, adaptation, and justice

Journal of Genetic Counseling, Volume 35, Issue 1, February 2026.
Abstract Logotherapy is a psychological approach originated by Viktor Frankl, shaped by the thesis that meaning can be discovered even in the most tragic of human circumstances, and through a human's will‐to‐meaning, that individuals have both freedom and responsibility to discover meanings in the moment and ultimate meanings from their unique ...
Nour Chanouha, Anna Chassevent, Ellen F. Macnamara, Kendra Schaa, Renata Thoeny, Janeta Tansey   +5 more
wiley   +1 more source

Rare single‐nucleotide variants of MLH1 and MSH2 genes in patients with Lynch syndrome

Cancer Reports
Background Approximately 5% of colorectal cancers (CRCs) are hereditary. Lynch syndrome (LS), also known as hereditary nonpolyposis colorectal cancer (HNPCC), is the most common form of recognized hereditary CRC.
Seyed Mohsen Mirabdolhosseini, Mohammad Yaghoob Taleghani, Leili Rejali, Hossein Sadeghi, Nayeralsadat Fatemi, Mehdi Tavallaei, Amin Famil Meyari, Narges Saeidi, Pardis Ketabi Moghadam, Amir Sadeghi, Hamid Asadzadeh Aghdaei, Mohammad Reza Zali, Ehsan Nazemalhosseini Mojarad   +12 more
doaj   +1 more source