Results 121 to 130 of about 42,200 (256)
Revista Médica Clínica Las Condes, 2017 Assessment for hereditary susceptibility to cancer is considered standard of care, as it impacts not only a clinician's understanding of cancer causation but also options for prevention and treatment.
Charité Ricker, MS, LCGC
doaj +1 more source
Molecular alterations in high‐grade neuroendocrine tumors of the small intestine
The Journal of Pathology, Volume 268, Issue 2, Page 215-226, February 2026.Abstract High‐grade neuroendocrine tumors of the small intestine are separated into two groups: well‐differentiated neuroendocrine tumors (NETs, high‐grade) and poorly differentiated neuroendocrine carcinomas (NECs). They represent very rare entities, with few molecular data available, and are very challenging to treat.
Agathe Hercent +9 more
wiley +1 more source
Distinct Roles of IL‐4, IL‐13, and IL‐22 in Human Skin Barrier Dysfunction and Atopic Dermatitis
Allergy, Volume 81, Issue 2, Page 480-497, February 2026.This study reports the distinct effects of IL‐4, IL‐13, and IL‐22 on bio‐stabilized human skin with intact barriers and immune cells. IL‐4, IL‐13, and IL‐22 upregulate inflammatory mediators, disrupt skin barrier integrity, and reciprocally modulate IL‐4Rα and IL‐22Rα1 receptors.
Paolo D'Avino +12 more
wiley +1 more source
Microsatellite Instability in Mouse Models of Colorectal Cancer
Canadian Journal of Gastroenterology and Hepatology, 2018 Microsatellite instability (MSI) is caused by DNA mismatch repair deficiency and is an important prognostic and predictive biomarker in colorectal cancer but relatively few studies have exploited mouse models in the study of its clinical utility ...
Nicola Currey +4 more
doaj +1 more source
Outcomes of Genetic Testing in a Genitourinary Genetics Clinic [PDF]
, 2018 Several known hereditary cancer syndromes confer an increased risk for genitourinary (GU)related malignancies. Various guidelines indicate when to refer patients to genetic counseling for GU-related hereditary cancer syndromes but there is limited ...
Pace, Annelise
core +1 more source
High-Level Production of MSH2 from Arabidopsis thaliana: A DNA Mismatch Repair System Key Subunit [PDF]
, 2010 Rodrigo Gómez +2 more
openalex +1 more source
Nucleic acids research, 2004 Besides orthologs of other eukaryotic mismatch-repair (MMR) proteins, plants encode MSH7, a paralog of MSH6. The Arabidopsis thaliana recognition heterodimers AtMSH2*MSH6 (AtMutSalpha) and AtMSH2*MSH3 (AtMutSbeta) were previously found to bind the same subsets of mismatches as their counterparts in other eukaryotes--respectively, base-base mismatches ...
Shiau-Yin, Wu +3 more
openaire +2 more sources
Genomic Profiling of Pediatric Solid Tumors With a Dual DNA/RNA Panel: JCCG‐TOP2 Study
Cancer Science, Volume 117, Issue 2, Page 522-535, February 2026.In the JCCG‐TOP2 nationwide pediatric cancer genomic profiling study, 204 patients' tumors and peripheral blood from 50 institutions across Japan were successfully analyzed using a dual DNA/RNA panel. A total of 147 (72%) had potentially actionable findings, including diagnostic, prognostic, and therapeutic findings in 111 (54%), 61 (30%), and 64 (31%),
Kayoko Tao +38 more
wiley +1 more source
Genomic Alteration Burden in Advanced Prostate Cancer and Therapeutic Implications. [PDF]
, 2019 The increasing number of patients with sequenced prostate cancer genomes enables us to study not only individual oncogenic mutations, but also capture the global burden of genomic alterations.
Bose, Rohit, Ryan, Matthew J
core +1 more source
Cancer Science, Volume 117, Issue 2, Page 566-575, February 2026.Malignant ovarian germ cell tumor subtypes exhibit distinct tumor microenvironments. Dysgerminomas harbor abundant nonexhausted T cells, with progenitor exhausted T cells present in 60% of PD‐1–positive cases. However, MHC class I expression is lost across all analyzed subtypes, suggesting that restoring class I expression in dysgerminomas may enhance ...
Miya Nakashima +13 more
wiley +1 more source