High-resolution mapping of heteroduplex DNA formed during UV-induced and spontaneous mitotic recombination events in yeast. [PDF]
, 2017 In yeast, DNA breaks are usually repaired by homologous recombination (HR). An early step for HR pathways is formation of a heteroduplex, in which a single-strand from the broken DNA molecule pairs with a strand derived from an intact DNA molecule.
Dominska, Margaret +3 more
core +3 more sources
Interaction between the Msh2 and Msh6 Nucleotide-binding Sites in the Saccharomyces cerevisiae Msh2-Msh6 Complex [PDF]
Journal of Biological Chemistry, 2010 Indirect evidence has suggested that the Msh2-Msh6 mispair-binding complex undergoes conformational changes upon binding of ATP and mispairs, resulting in the formation of Msh2-Msh6 sliding clamps and licensing the formation of Msh2-Msh6-Mlh1-Pms1 ternary complexes.
Victoria V, Hargreaves +4 more
openaire +2 more sources
FGFR2 amplification in colorectal adenocarcinoma [PDF]
, 2017 FGFR2 is recurrently amplified in 5% of gastric cancers and 1%–4% of breast cancers; however, this molecular alteration has never been reported in a primary colorectal cancer specimen.
Carter, Jamal H +6 more
core +2 more sources
A Novel Splice-Site Mutation in MSH2 Is Associated With the Development of Lynch Syndrome
Frontiers in Oncology, 2020 Lynch syndrome (LS) is an inherited autosomal dominant disorder caused by germline mutations of mismatch repair (MMR) genes, including MSH2, MSH6, PMS2, and MLH1.
Juyi Li +16 more
doaj +1 more source
Msh2 acts in medium-spiny striatal neurons as an enhancer of CAG instability and mutant huntingtin phenotypes in Huntington's disease knock-in mice. [PDF]
PLoS ONE, 2012 The CAG trinucleotide repeat mutation in the Huntington's disease gene (HTT) exhibits age-dependent tissue-specific expansion that correlates with disease onset in patients, implicating somatic expansion as a disease modifier and potential therapeutic ...
Marina Kovalenko +11 more
doaj +1 more source
Pathways and Mechanisms that Prevent Genome Instability in Saccharomyces cerevisiae. [PDF]
, 2017 Genome rearrangements result in mutations that underlie many human diseases, and ongoing genome instability likely contributes to the development of many cancers.
Kolodner, Richard D +1 more
core +1 more source
MSH2 (human mutS homolog 2) [PDF]
Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2011 Review on MSH2 (human mutS homolog 2), with data on DNA, on the protein encoded, and where the gene is implicated.
E Domingo, S Jr Schwartz
openaire +1 more source
Clinical Epigenetics, 2019 Background Mismatch repair (MMR)-deficiency increases the risk of colorectal tumorigenesis. To determine whether the tumors develop on a normal or disturbed epigenetic background and how radiation affects this, we quantified genome-wide histone H3 ...
Maria Herberg +10 more
doaj +1 more source
Development and preliminary testing of the psychosocial adjustment to hereditary diseases scale [PDF]
, 2013 Background: The presence of Lynch syndrome (LS) can bring a lifetime of uncertainty to an entire family as members adjust to living with a high lifetime cancer risk.
Cox, Janet E. +9 more
core +1 more source