Results 31 to 40 of about 11,769 (169)
Metallation pathway of a plant metallothionein: Cicer arietinum MT2
Journal of Inorganic Biochemistry, 2020 ISSN:0162 ...
Salim, Alma +2 more
openaire +4 more sources
The International Journal of Biological Markers, 2010 Purpose To analyze the behavior of matrix metalloproteinases (MMPs) in their active state in patients with bladder cancer. Method A retrospective study of 50 patients with localized bladder cancer who underwent tumor resection between June 2006 and June ...
Mohammad A. Mohammad +3 more
doaj +1 more source
Structure-based discovery of potent and selective melatonin receptor agonists
eLife, 2020 Melatonin receptors MT1 and MT2 are involved in synchronizing circadian rhythms and are important targets for treating sleep and mood disorders, type-2 diabetes and cancer.
Nilkanth Patel +8 more
doaj +1 more source
Absence seizures: Update on signaling mechanisms and networks
Epilepsia Open, EarlyView.Abstract Absence seizures (AS) are a hallmark of genetic generalized epilepsies (GGE), characterized by brief episodes of impaired consciousness accompanied by electroencephalographic spike‐and‐wave discharges (SWDs). Traditionally attributed to cortico‐thalamo‐cortical (CTC) dysrhythmia, emerging evidence suggests a more intricate pathophysiological ...
Ozlem Akman, Filiz Onat
wiley +1 more source
Environmental Health and Preventive Medicine, 2018 Background The Japan Environment and Children’s Study (JECS) is a nation-wide birth cohort study investigating environmental effects on children’s health and development.
Miyuki Iwai-Shimada +13 more
doaj +1 more source
The Kaohsiung Journal of Medical Sciences, EarlyView.ABSTRACT Osteoarthritis (OA) is a prevalent degenerative joint disease. This study combines bioinformatics analysis with in vivo and in vitro experiments to elucidate the molecular mechanisms through which melatonin (MT) regulates mitophagy to alleviate OA.
Chao Huang +4 more
wiley +1 more source
Nonlinear Vibration Characteristic Analysis of Electric Vehicle–Road Coupling System
International Journal of Mechanical System Dynamics, EarlyView.ABSTRACT In‐wheel motor drive is the developing direction of automobile electrification and intelligence. However, the increased unsprung mass in in‐wheel motor‐driven electric vehicles (IWMEVs) leads to higher dynamic tire loads, thereby intensifying vehicle–road coupling interactions. To address this problem, an 11‐degree‐of‐freedom nonlinear dynamic
Guizhen Feng, Shaohua Li, Xuewei Wang
wiley +1 more source
Frontiers in Microbiology, 2020 Adalimumab (ADA), a fully human monoclonal tumor necrosis factor (TNF)-α antibody, is one of the most widely used biologics in the treatment of inflammatory diseases. However, ADA can exacerbate infectious conditions, induce paradoxical reactions such as
Hisako Kurozumi-Karube +5 more
doaj +1 more source
Acta Psychiatrica Scandinavica, EarlyView.ABSTRACT Background Schizophrenia is characterized by positive, negative, and cognitive symptoms. Current pharmacological treatments often fail to address cognitive deficits. In this review of clinical trials, we aim to identify studies that explore neurobiological (non‐psychological) strategies to address Cognitive Impairment Associated with ...
Bahareh Peyrovian +3 more
wiley +1 more source
Novel approaches for drug development against chronic primary pain: A systematic review
British Journal of Pharmacology, EarlyView.Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus +5 more
wiley +1 more source