Results 31 to 40 of about 38,443 (210)

The genomic response of human granulosa cells (KGN) to melatonin and specific agonists/antagonists to the melatonin receptors

Scientific Reports, 2022
Melatonin is a known modulator of follicle development; it acts through several molecular cascades via binding to its two specific receptors MT1 and MT2. Even though it is believed that melatonin can modulate granulosa cell (GC) functions, there is still
Asma Arjoune, Marc-André Sirard
doaj   +1 more source

Profile of melatonin and its receptors and synthesizing enzymes in cumulus–oocyte complexes of the developing sheep antral follicle—a potential estradiol-mediated mechanism

Reproductive Biology and Endocrinology, 2019
Background Melatonin is an amine hormone that plays an important role in regulating mammalian reproduction. This study aimed to investigate the expression pattern of melatonin synthesis enzymes AANAT and HIOMT and melatonin receptors MT1 and MT2 in sheep
Longfei Xiao, Junjie Hu, Liangli Song, Yong Zhang, Weitao Dong, Yuting Jiang, Quanwei Zhang, Ligang Yuan, Xingxu Zhao   +8 more
doaj   +1 more source

Assisted evolution enables HIV-1 to overcome a high trim5α-imposed genetic barrier to rhesus macaque tropism [PDF]

, 2013
Diversification of antiretroviral factors during host evolution has erected formidable barriers to cross-species retrovirus transmission. This phenomenon likely protects humans from infection by many modern retroviruses, but it has also impaired the ...
A Kuroishi, A Lassaux, A Reymond, AM Sheehy, AM Sheehy, B Jia, B Pacheco, B Song, BK Ganser-Pornillos, C Aberham, CA Virgen, CA Virgen, CH Liao, D Blanco-Melo, D Perez-Caballero, D Perez-Caballero, E Battivelli, EE Nakayama, F Zhang, F Zhang, G Brennan, GB Mortuza, GJ Towers, H Yang, HL Wiegand, Jeremy Luban, JW Bainbridge, K Hrecka, KR McCarthy, L Yin, M Pizzato, M Stremlau, M Stremlau, M Stremlau, M Stremlau, M Veillette, MJ Perron, MJ Perron, MR Auerbach, MW McNatt, MW Yap, MW Yap, N Van Damme, O Pornillos, Paul D. Bieniasz, R Mariani, RM Newman, S Cowan, S Ohkura, S Ohkura, S Sebastian, Sam J. Wilson, SB Kutluay, Sebla B. Kutluay, SJ Neil, SJ Rihn, SJ Wilson, SJ Wilson, SJ Wilson, SL Sawyer, Steven J. Soll, SY Lim, T Hatziioannou, T Hatziioannou, T Hatziioannou, T Hatziioannou, T Hatziioannou, Theodora Hatziioannou, V Zennou, X Yu, Y Soneoka, YH Zheng, YJ Zhang, Z Ambrose, Z Keckesova, Z Kratovac   +75 more
core   +3 more sources

Novel Conformationally Constrained Analogues of Agomelatine as New Melatoninergic Ligands

Molecules, 2012
Novel conformationally restricted analogues of agomelatine were synthesized and pharmacologically evaluated at MT1 and MT2 melatoninergic receptors. Replacement of the N-acetyl side chain of agomelatine by oxathiadiazole-2-oxide (compound 3), oxadiazole ...
Marouan Rami, Elodie Landagaray, Mohamed Ettaoussi, Koussayla Boukhalfa, Daniel-Henri Caignard, Philippe Delagrange, Pascal Berthelot, Saïd Yous   +7 more
doaj   +1 more source

Role of melatonin receptors in the effect of estrogen on brain edema, intracranial pressure and expression of aquaporin 4 after traumatic brain injury [PDF]

Iranian Journal of Basic Medical Sciences, 2018
Objective(s): Traumatic brain injury (TBI) is one of the most common causes of death and disability in modern societies. The role of steroids and melatonin is recognized as a neuroprotective factor in traumatic injuries.
Nader Shahrokhi, Mohammad khaksari, Gholamreza Asadikaram, Zahra soltani, Nava Shahrokhi   +4 more
doaj   +1 more source

Activation of MT1/MT2 to Protect Testes and Leydig Cells against Cisplatin-Induced Oxidative Stress through the SIRT1/Nrf2 Signaling Pathway

Cells, 2022
There is growing concern that chemotherapy drugs can damage Leydig cells and inhibit the production of testosterone. Increasing evidence shows that melatonin benefits the reproductive process. This study mainly explores the protective effect and possible
Junqiang Zhang, Yuan Fang, Dongdong Tang, Xingyu Xu, Xiaoqian Zhu, Shusheng Wu, Hui Yu, Huiru Cheng, Ting Luo, Qunshan Shen, Yang Gao, Cong Ma, Yajing Liu, Zhaolian Wei, Xiaoyu Chen, Fangbiao Tao, Xiaojin He, Yunxia Cao   +17 more
doaj   +1 more source

The stransverse mass, MT2, in special cases

, 2011
This document describes some special cases in which the stransverse mass, MT2, may be calculated by non-iterative algorithms. The most notable special case is that in which the visible particles and the hypothesised invisible particles are massless -- a ...
A Barr, AJ Barr, AJ Barr, AJ Barr, AJ Barr, AJ Barr, AJ Barr, AJ Barr, AJ Barr, B Gripaios, BC Allanach, C Lester, CG Lester, Christopher G. Lester, DR Tovey, DR Tovey, G Arnison, G Polesello, GG Ross, H-C Cheng, I-W Kim, L Randall, M Burns, M Serna, MM Nojiri, P Konar, P Konar, T Aaltonen, WS Cho, WS Cho, WS Cho, WS Cho, WS Cho   +32 more
core   +1 more source

Resonant Higgs boson pair production in the $hh\rightarrow b\bar{b} \; WW \rightarrow b\bar{b} \ell^+ \nu \ell^- \bar\nu$ decay channel [PDF]

, 2015
Adding a scalar singlet provides one of the simplest extensions of the Standard Model. In this work we briefly review the latest constraints on the mass and mixing of the new Higgs boson and study its production and decay at the LHC.
Martin-Lozano, Victor, Moreno, Jesus M., Park, Chan Beom   +2 more
core   +4 more sources

Reducing combinatorial uncertainties: A new technique based on MT2 variables [PDF]

, 2011
We propose a new method to resolve combinatorial ambiguities in hadron collider events involving two invisible particles in the final state. This method is based on the kinematic variable MT2 and on the MT2-assisted-on-shell reconstruction of invisible ...
A Barr, A Rajaraman, AJ Barr, AJ Barr, AJ Barr, B Abbott, B Gripaios, B Gripaios, C Lester, C Lester, CB Park, Chan Beom Park, Diego Guadagnoli, DR Tovey, EL Berger, EL Berger, G Mahlon, G Mahlon, G Mahlon, H Zhang, J Alwall, J Alwall, J Smith, K Choi, K Choi, Kiwoon Choi, M Aliev, M Burns, MM Nojiri, MM Nojiri, P Konar, PM Nadolsky, T Aaltonen, T Stelzer, VD Barger, VM Abazov, VM Abazov, WS Cho, WS Cho, WS Cho, WS Cho   +40 more
core   +2 more sources

Cu(I) binds to Zn7-MT2 via two parallel pathways

Metallomics, 2023
Abstract Metallothionein proteins are essential for Cu(I) and Zn(II) homeostasis as well as heavy metal detoxification. The metallation properties of MT2 are of great interest due to their wide patterns of expression and correlation with multiple diseases including cancers, neurological disorders, and respiratory diseases.
Adyn Melenbacher, Martin J Stillman
openaire   +2 more sources