Results 81 to 90 of about 38,443 (210)

Escape Body: A Gamified Problem‐Based Learning Project in Primary Education

School Science and Mathematics, EarlyView.
ABSTRACT Young learners' lack of motivation to study scientific‐related subjects nowadays is a topic of concern in our society. This study followed a quasi‐experimental design with a predominantly quantitative methods approach, complemented by qualitative data, to investigate how the combination of gamified and problem‐based learning could influence ...
Sergio Tirado‐Olivares, Maria Navío‐Inglés, Javier del Olmo‐Muñoz, Rosa M. Toledano   +3 more
wiley   +1 more source

MT2-MMP induces proteolysis and leads to EMT in carcinomas

Oncotarget, 2016
Epithelial-mesenchymal transition (EMT) is critical for carcinoma invasiveness and metastasis. To investigate the role of membrane-type-2 matrix metalloproteinase (MT2-MMP) in EMT, we generated lentiviral constructs of wild-type (WT) and an inactive Glu260Ala (E260A) mutant MT2-MMP and derived stably transfected HCT116 and A549 cell lines.
Liu, Yusi, Sun, Xiaojiao, Feng, Jinfa, Deng, Li-Li, Liu, Yihao, Li, Bokang, Zhu, Mingyue, Lu, Changlian, Zhou, Lingyun   +8 more
openaire   +3 more sources

Searches for physics beyond the standard model with the M_(T2) variable in hadronic final states with and without disappearing tracks in proton–proton collisions at √s = 13 TeV [PDF]

, 2020
Two related searches for phenomena beyond the standard model (BSM) are performed using events with hadronic jets and significant transverse momentum imbalance.
Anderson, D., Bornheim, A., Cerri, O., Dubinin, M., Dutta, I., Lawhorn, J. M., Lu, N., Mao, J., Newman, H. B., Nguyen, T. Q., Pata, J., Sirunyan, A. M., Spiropulu, M., Vlimant, J. R., Xie, S., Zhang, Z., Zhu, R. Y.   +16 more
core   +1 more source

Identification of Metallothionein Gene in Human Plasma: A Molecular Analysis of Cadmium and Lead Pollution in Gas Station Environment

Jurnal Pendidikan IPA Indonesia, 2018
Metallothionein (MTs) is a protein that binds to metals, cysteine-rich and has low molecular weights. Metallothionein binds metals and has some essential cellular functions, such as transportation, storage, and metal detoxification.
N. K. Dewi, A. Yuniastuti, A. M. A. Ahmed   +2 more
doaj   +1 more source

Pharmacological and Mechanistic Interventions for Cognitive Impairment Associated With Schizophrenia: A Review of Registered Clinical Trials

Acta Psychiatrica Scandinavica, Volume 153, Issue 5, Page 402-431, May 2026.
ABSTRACT Background Schizophrenia is characterized by positive, negative, and cognitive symptoms. Current pharmacological treatments often fail to address cognitive deficits. In this review of clinical trials, we aim to identify studies that explore neurobiological (non‐psychological) strategies to address Cognitive Impairment Associated with ...
Bahareh Peyrovian, Lena Palaniyappan, Theodore T. Kolivakis, Howard C. Margolese   +3 more
wiley   +1 more source

Gestational Melatonin Supplementation Attenuates Maternal Sleep Deprivation‐Induced Steatohepatitis Susceptibility in Offspring

Cell Proliferation, Volume 59, Issue 5, May 2026.
Maternal SD during pregnancy enhances the development of diet‐induced NASH in adult offspring of both sexes through an NR4A3‐dependent mechanism, characterised by heightened inflammation and increased apoptosis. Maternal melatonin supplementation effectively alleviates this increased susceptibility to NASH in offspring.
Fei Guo, Zexin Yang, Junsen She, Chen Fang, Yizhi Hu, Hefeng Huang, Ling Gao   +6 more
wiley   +1 more source

Brain Proteomic Responses to Glucocorticoids and Their Relationship With Transcriptome: A Systematic Meta‐Analysis

The FASEB Journal, Volume 40, Issue 8, 30 April 2026.
An overlap between proteomic and transcriptomic findings in experiments testing brain responses to glucocorticoids. A shows that 455 proteins responsive to glucocorticoids were not confirmed at the transcriptomic level while 4 proteins were matched with significant differences in mRNA in all 8 datasets derived from transcriptomic experiments.
Grzegorz R. Juszczak
wiley   +1 more source

Circadian Pattern of Melatonin MT1 and MT2 Receptor Localization in the Rat Suprachiasmatic Nucleus

Journal of Circadian Rhythms, 2015
The suprachiasmatic nucleus (SCN) is the circadian pacemaker. The pineal hormone melatonin is involved in the regulation of circadian phase. As a part of the circadian system its synthesis and secretion is under SCN control.
Nermien Waly, Richard Hallworth
doaj   +1 more source

The Higgs mass as a function of the compactification scale

, 2003
We calculate to a few percent precision the Higgs potential in a model with supersymmetry broken by boundary conditions on an extra-dimension, compactified to a segment of length $L$, and a top quark quasi-localized on one of the two boundaries.
Antoniadis, Antoniadis, Antoniadis, Barbieri, Barbieri, Barbieri, Barbieri, Brignole, Delgado, Delgado, Ghilencea, Guido Marandella, Hempfling, Marti, Michele Papucci, Riccardo Barbieri, Scherk, Scherk, Strumia   +18 more
core   +2 more sources

The Potential Functions and Beneficial Effects of Melatonin on Cognitive Impairment, Neuroinflammation, Blood–Brain Barrier Leakage, and Synaptic Dysfunction in the Offspring of Mice Exposed to Gestational Intermittent Hypoxia

Brain and Behavior, Volume 16, Issue 4, April 2026.
Melatonin rescues the cognitive deficits induced by gestational intermittent hypoxia exposure in male offspring mice, and these results were associated with neuroinflammation, BBB integrity, and alterations in synaptic function. ABSTRACT Introduction Gestational intermittent hypoxia (GIH), which serves as a model for obstructive sleep apnea (OSA), is ...
Xue‐Yan Li, Yun‐Zhoug Cheng, Yue‐Ming Zhang, Fei Hu, Shi‐Kun Fang, Gui‐Hai Chen, Yu Wang   +6 more
wiley   +1 more source