Results 121 to 130 of about 156,870 (288)
Expanding the Phenotype of TUFM‐Related Combined Oxidative Phosphorylation Deficiency 4
American Journal of Medical Genetics Part A, EarlyView.ABSTRACT Combined oxidative phosphorylation deficiency 4 (COXPD4) is a rare mitochondrial condition caused by biallelic deleterious variants in the nuclear‐encoded gene TUFM. To date, most individuals with COXPD4 have presented with encephalopathy, hypotonia, and abnormal brain imaging. Many of the reported individuals died in infancy. We aim to expand
Noémie Villeneuve‐Cloutier +2 more
wiley +1 more source
Animal Models and Experimental Medicine, EarlyView.We established that mixed DdCBE microinjection is an efficient, heritable, and precise strategy for generating multiplex mtDNA mutant rats. This advancement significantly expands the utility of DdCBEs for mitochondrial disease modeling, providing a robust platform for exploring the pathogenic mechanisms of complex mtDNA mutations and developing ...
Xu Zhang +14 more
wiley +1 more source
European Journal of Entomology, 2010 This is the first study of the morphological and molecular variation in two peripheral populations of the butterfly Jutta Arctic, Oeneis jutta, a glacial relict species endangered by the fragmentation of its habitat in Poland.
Lech KRZYSZTOFIAK +5 more
doaj +1 more source
Systematics of the North American menhadens: molecular evolutionary reconstructions in the genus Brevoortia (Clupeiformes: Clupeidae) [PDF]
, 2007 Evolutionary associations among the four North American species of menhadens (Brevoortia spp.) have not been thoroughly investigated. In the present study, classifications separating the four species into small-scaled and large-scaled groups were ...
Anderson, Joel D.
core
Annals of Neurology, EarlyView.Objective Cerebral ischemic stroke causes neuronal oxygen/energy deprivation, disrupting mitochondrial function including reduced membrane potential and bioenergetics, exacerbating neuronal injury. Mitochondrial defects are, therefore, a central neuropathological node and potential therapeutic target.
Ning Bian +9 more
wiley +1 more source
Mitochondrial DNA (mtDNA) and schizophrenia
European Psychiatry, 2011 AbstractThe poorly understood aetiology of schizophrenia is known to involve a major genetic contribution even though the genetic factors remain elusive. Most genetic studies are based on Mendelian rules and focus on the nuclear genome, but current studies indicate that other genetic mechanisms are probably involved.
B, Verge +5 more
openaire +2 more sources
Advanced NanoBiomed Research, EarlyView.This review highlights how autoimmune diseases arise from intertwined immunological, genetic, and environmental factors, emphasizing gut microbiota dysbiosis as a pivotal driver. It outlines emerging nanotechnology‐based strategies—such as liposomes, hydrogels, and polymeric nanoparticles—that enhance targeted drug delivery, minimize systemic toxicity,
Md. Meraj Ansari +5 more
wiley +1 more source
Knowledge and Management of Aquatic Ecosystems, 1996 Mitochondrial DNA (mtDNA) variation in the white-clawed crayfish, Austropotamobius pallipes pallipes, was examined by restriction endonuclease analysis of samples obtained from three geographical locations representing two very différent habitats : the ...
GRANDJEAN F., SOUTY-GROSSET C.
doaj +1 more source
Genetic structure of Pleurobranchaea maculata in New Zealand : a thesis presented in partial fulfilment of the requirements for the degree of Doctor of Philosophy (PhD) in Genetics, The New Zealand Institute for Advanced Study, Massey University, Auckland, New Zealand [PDF]
, 2016 The grey side-gilled sea slug (Pleurobranchaea maculata), which is native to the western and south Pacific, is known to contain high concentrations of tetrodotoxin (TTX). P. maculata populations around New Zealand exhibit individual, spatial and temporal
Yildirim, Yeşerin
core
Animal Research and One Health, EarlyView.Woody breast compromises meat quality leading to reduced consumer appeal. Although its causes are unclear, improvements observed with certain dietary supplements suggest that gut health may influence woody breast development. Ribonucleotide reductase subunit RRM2 is vital for mitochondrial function and gastrointestinal integrity, and alteration in its ...
Majid Shakeri +8 more
wiley +1 more source