Results 101 to 110 of about 120,377 (263)

Klotho‐Derived Peptide 1 Protects against Acute Kidney Injury by Directly Targeting Mitochondrial ATAD3A

Advanced Science, EarlyView.
This study uncovers that KP1, a Klotho‐derived peptide, protects the kidney against acute kidney injury, a clinical syndrome with high morbidity and mortality. KP1 enters tubular epithelial cells via endocytosis, directly interacts with the mitochondrial ATAD3A/HIGD2A complex, thereby preventing cytochrome c release, and caspases activation, and ...
Xiaoyao Zhang, Shihui Lin, Tianyu Wu, Zhixin Zhang, Hong Zhou, Xue Hong, Youhua Liu   +6 more
wiley   +1 more source

Genetic Diversity and Population Structure of Amphidromous Goby (Stiphodon semoni) in Western Part of Southern Java Waters

Jurnal Ilmiah Perikanan dan Kelautan
Graphical Abstract Research Highlight • The genetic diversity of Stiphodon semoni is high. • All populations have high haplotype diversity except for Cimaja. • No genetic structure is observed within the populations of semoni. • The population
Ahmad Romdon, Charles P. H. Simanjuntak, Sulistiono, Augy Syahailatua   +3 more
doaj  

CDK4/MERCs/PINK1 Axis Drives PFOA/HFPO‐TA‐Induced Cardiac Senescence via Mitophagy Defect and cGAS‐STING Activation: In Vitro Amelioration by Cycloastragenol

Advanced Science, EarlyView.
The present study demonstrated that PFOA and HFPO‐TA exposure suppressed CDK4, disrupted MERCs and impaired PINK1/Parkin‐mediated mitophagy, thereby accelerating cardiac senescence, whereas CAG effectively reversed these pathological changes in vitro. Our findings identify CDK4 as a critical regulator bridging mitophagy defects and cardiac senescence ...
Nuo‐Wa Li, Jun‐Ze Jiang, Ying‐Ying Liu, Tian‐Tian Zhang, Kanwar Kumar Malhi, Xin Yao, Jin‐Long Li   +6 more
wiley   +1 more source

Genetic Relationship amongst Marica, Kacang Goat and Capra species

International Journal of Agriculture System, 2015
Marica goat is an endemic species that can be found only in South Sulawesi, Indonesia. It has been reported by the FAO as endangered species because its number of population has been significantly decreased. Domestication by local people has been done by
Rosdiana Ngitung, Herry Sonjaya, Syamsuddin Hasan, Wempie Wempie   +3 more
doaj   +1 more source

Mitochondrial DNA signals of late glacial recolonization of Europe from near Eastern refugia [PDF]

, 2012
Human populations, along with those of many other species, are thought to have contracted into a number of refuge areas at the height of the last Ice Age.
Reisberg T., Tamm, Erika, Karmin, M., Pereira, L., Al Zahery N., Houshmand M., Tamm, E, Macaulay V, Reisberg, T., Pala M., Gamble C., Villems R, Houshmand M, Macaulay, V., Karmin M., Hatina J, Reisberg, Tuuli, Gamble, Clive, Kashani, Baharak Hooshiar, Accetturo, M., Baird D, Woodward S. R., Woodward SR, Accetturo, M, Reidla, M, Sanati, Mohammad Hossein, Gamble, C, Davies W, Carossa, V., Karmin M, Achilli, A., Kashani, B.H., Reisberg, T, Carelli, Valerio, Macaulay, Vincent, Tamm E, Soares, Pedro, Achilli, A, Torroni, Antonio, Sanati M. H., Soares, P, Woodward, SR, Hooshiar Kashani, Baharak, Carossa, V, Torroni, A, Villems, Richard, Rychkov, Sergei, Rychkov S, Richards, MB, Metspalu E., Gandini, F., Karmin, Monika, Pereira, Joana B., Al Zahery N, Metspalu, E., Richards, M.B., PEREGO, UGO ALESSANDRO, Achilli A., Semino, O, Soares P., Olivieri, A, Soares P, Karmin, M, Angerhofer N, Carelli, V., Torroni A., Hatina J., Pala, M., Pereira L, Davies, W, Villems, R, Carelli V, Pereira, J.B., Perego, U.A., Davies, William, Richards MB, Gandini, F, Torroni, A., Reidla, Maere, Olivieri A., Olivieri, Anna, Hatina, J, Perego, Ugo A., Semino, O., Davies, W., Woodward, Scott R., Baird D., Richards M. B., Hooshiar Kashani B., Macaulay V., Villems R., Al-Zahery, N, Metspalu, E, Rychkov, S., Pereira L., Al-Zahery, N., Baird, Douglas, Reisberg T, Angerhofer, N, Pereira JB, Pereira, L, Gandini, Francesca, Gamble C, Sanati MH, Olivieri, A., Hatina, J., Accetturo, Matteo, Pereira, Luísa, Gamble, C., Houshmand, Massoud, Pala, M, Carossa, Valeria, Woodward, S.R., Reidla M, Hossein Sanati, M, Pala, Maria, Angerhofer N., Semino O., Al-Zahery, Nadia, Metspalu, Ene, Davies W., Macaulay, V, Perego U. A., Houshmand, M., Angerhofer, N., Sanati, M.H., Houshmand, M, Tamm E., Pereira, JB, Baird, D, Metspalu E, Achilli, Alessandro, Angerhofer, Norman, Carelli, V, Semino, Ornella, Villems, R., Pereira J. B., Carossa V., Reidla M., Rychkov S., Hooshiar Kashani, B, Perego, UA, Hatina, Jiři, Richards, Martin B., Baird, D., Soares, P., Gandini F., Accetturo M., Rychkov, S   +148 more
core   +1 more source

KLF5 Downregulation Links Impaired BNIP3‐Mediated Mitophagy to Inflammatory Valve Remodeling in Calcific Aortic Valve Disease

Advanced Science, EarlyView.
In human CAVD, KLF5 is reduced in VIC‐rich regions and remodeling/stress‐associated VIC states. In VICs, KLF5 sustains BNIP3 promoter activity and BNIP3‐mediated mitophagy, thereby limiting cytosolic mtDNA accumulation. KLF5 loss weakens mitochondrial quality control and enhances mtDNA‐sensitive STING/NF‐κB/NLRP3 inflammatory signaling under osteogenic
Jin‐Hui Bian, Jia‐Xi Gu, Zhang Yue, Chun‐Ze Yuan, Hai‐Bin Ji, Ao Li, Yu Zhong, Xiu‐Fan Xu, Yu‐Qiu He, Ye‐Fan Jiang, Hong‐Shan Chen, Xiang Chen, Meng‐Lin Chao, Yong‐Feng Shao   +13 more
wiley   +1 more source

mtDNA-depleted TE8 and TE11 cells by knockdown of TFAM gene expression.

, 2018
(A) By short hairpin RNA knockdown of TFAM gene expression, the mRNA expression of TFAM was silenced to about 50% compared with non-target control cells in both TE8 and TE11 cells.
Yasunori Masuike (4857526), Yasuhiro Miyazaki (524725), Yukinori Kurokawa (4857523), Koji Tanaka (559903), Kiyokazu Nakajima (4857517), Makoto Yamasaki (813466), Tsuyoshi Takahashi (376911), Masaki Mori (30875), Yuichiro Doki (402704), Tomoki Makino (4857520)   +9 more
core   +1 more source

Mitochondrial DNA deletions and neurodegeneration in multiple sclerosis [PDF]

, 2010
Cerebral atrophy is a correlate of clinical progression in multiple sclerosis (MS). Mitochondria are now established to play a part in the pathogenesis of MS.
Turnbull, Doug M, Kim J. Krishnan, Iryna Ziabreva, Owain Howell, Graham R. Campbell, Don J. Mahad, Reynolds, Richard, Owen Howell, Mahad, Don J, Reeve, Amy K, Amy K. Reeve, Richard Reynolds, Ziabreva, Iryna, Campbell, Graham R, Lassmann, Hans, Doug M. Turnbull, Howell, Owen, Krishnan, Kim J, Hans Lassmann   +18 more
core   +1 more source

Uhrf1‐Mediated PKM2 Degradation via Ubiquitination Alleviates Inflammation and Pyroptosis in Inflammatory Bowel Disease

Advanced Science, EarlyView.
Uhrf1‐mediated PKM2 ubiquitination and degradation repressed the nuclear translocation of PKM2, and EPT served as a molecular glue capable of targeting the Uhrf1–PKM2 complex to alleviate the IBD course, suggesting that the Uhrf1–PKM2 axis was a previously unrecognized strategy for treating IBD.
Juan Zhang, Xin‐Rong Xu, Hui‐Lin Zhang, Qi‐Meng Zhu, Xin‐Yuan Li, Xi‐Peng Shang, Jing‐Hui Du, Christophe Morisseau, Feng Qiu, Cheng‐Peng Sun   +9 more
wiley   +1 more source

Mitochondrial and Y-chromosome diversity of the Tharus (Nepal): a reservoir of genetic variation [PDF]

, 2009
Background Central Asia and the Indian subcontinent represent an area considered as a source and a reservoir for human genetic diversity, with many markers taking root here, most of which are the ancestral state of eastern and western haplogroups ...
Achilli Alessandro, FORNARINO S, Ramona Maranta, Fornarino, Simona, Santachiara-Benerecetti Silvana A, Pala, Maria, Vincenza Battaglia, Antonio Torroni, MARANTA R, Torroni Antonio, Ornella Semino, Fornarino Simona, Pala Maria, BENERECETTI, AUGUSTA SILVANA, Battaglia, Vincenza, Modiano Guido, Achilli, Alessandro, Semino, Ornella, Santachiara-Benerecetti, Silvana A, MODIANO G, PALA M, Semino Ornella, Maranta Ramona, Simona Fornarino, Maranta, Ramona, Silvana A Santachiara-Benerecetti, Battaglia Vincenza, Guido Modiano, Modiano, Guido, Torroni, Antonio, Maria Pala, Alessandro Achilli   +31 more
core   +1 more source