Results 101 to 110 of about 123,318 (262)

mtDNA alignment

, 2022
mtDNA ...
Ryan Bracewell (4350736)
core   +1 more source

Molecular Signatures of HIV‐Induced Neuroinflammation and Neurodegeneration in Human Cerebral Organoids: Identification of Therapeutic Targets for NeuroHIV

Advanced Science, EarlyView.
HIV preferentially infects microglia, activating IL‐17A‐driven IFN‐γ/STAT1, CEBPB, and NF‐κB signaling that converges with cGAS‐STING and Notch–NEURL1 pathways, promoting neuroinflammation, mitochondrial dysfunction, and synaptic impairment. cART suppresses viral replication, attenuates inflammatory signaling, and at least partially restores ...
Karthick Chennakesavan, Malaroviyam Samikkannu, Shreyan Gupta, Olasunkanmi Israel Tayo, Arpan Acharya, James J. Cai, Siddappa N. Byrareddy, Thangavel Samikkannu   +7 more
wiley   +1 more source

Genetic identification of a non-native species introgression into wild population of the field cricket Gryllus campestris (Orthoptera: Gryllidae) in Central Europe

European Journal of Entomology, 2016
Two species of the genus Gryllus occur in Europe: G. campestris and G. bimaculatus. The first is widely distributed in the north-western Palaearctic, while the second, G. bimaculatus, occurs predominantly in the Mediterranean area.
Hanna PANAGIOTOPOULOU, Mateusz BACA, Katarzyna BACA, Paweł SIENKIEWICZ, Piotr ŚLIPIŃSKI, Michał ŻMIHORSKI   +5 more
doaj   +1 more source

Study of the Human Mitochondrial DNA Polymorphism [PDF]

, 2006
Traces of Paleolithic exodus routes of modern humans from Africa to Europe have been studied genetically using female specific ancestral lineages via mitochondrial DNA (mtDNA).
Willis, Catherine
core  

A genetic contribution from the Far East into Ashkenazi Jews via the ancient Silk Road [PDF]

, 2015
Contemporary Jews retain a genetic imprint from their Near Eastern ancestry, but obtained substantial genetic components from their neighboring populations during their history.
Jits van Straten, Li, Yu-Chun, Wang, Hua Wei, Wen Zhang, Yao, Yong-Gang, Hua-Wei Wang, Wang, Hua-Wei, Yu-Chun Li, Qing-Peng Kong, Yao, Yong Gang, Tian, Jiao-Yang, Li, Yu Chun, Kong, Qing-Peng, Jiao-Yang Tian, Richards, Martin B., Yong-Gang Yao, Tian, Jiao Yang, van Straten, Jits, Zhang, Wen, Kong, Qing Peng, Martin B. Richards, Richards, Martin B.; id_orcid   +21 more
core   +1 more source

LAPTM5 Downregulation‐Driven VAMP8 Phosphorylation Impairs Autophagosome‐Lysosome Fusion and Aggravates Septic Acute Lung Injury

Advanced Science, EarlyView.
LAPTM5 functions as a critical molecular scaffold bridging PGAM5 and VAMP to facilitate PGAM5‐mediated dephosphorylation of VAMP8. This cascade promotes autophagosome‐lysosome fusion, restores impaired autophagic flux, and clears damaged mitochondria, thereby mitigating cellular oxidative stress and systemic inflammation.
Lang Jiang, Qilan Li, Hao Liu, Xuehui Gao, Hongyu Nie, Lang Chen, Mei He, Xuefeng Li, Xiangming Fang, Jiqian Xu, Hao Zhang, Jiahong Xia, You Shang   +12 more
wiley   +1 more source

Decoding Biomolecular Phase Separation: From Physiological Roles to Pathological Mechanisms and Therapeutic Biomaterials Design

Advanced Science, EarlyView.
This review systematically elaborates on the mechanisms underlying physiological regulation and pathological dysregulation of biomolecular phase separation. It also summarizes advances in phase‑separation‑targeted therapeutic strategies and the design of functional biomaterials inspired by this process.
Jiawei Zhu, Jingbo Dong, Qiufang Gong, Xuejiao Song, Zhifa Shen, Chao Liang   +5 more
wiley   +1 more source

Mitochondrial DNA-based genetic evaluation of autochthonous cattle breeds in Croatia

Czech Journal of Animal Science, 2014
Genetic diversity and phylogenetic relationship of three Croatian autochthonous cattle breeds was analyzed using a sequence of the mtDNA D-loop region. Among Busha, Istrian, and Slavonian Syrmian Podolian cattle 146 unrelated animals were tested.
A. Ivanković, S. Paprika, J. Ramljak, P. Dovč, M. Konjačić   +4 more
doaj   +1 more source

Yoda1‐Functionalized Nanozymes Coordinate Piezo1 Activation and Mitochondrial Protection to Reprogram the Diabetic Osteoimmune Micromilieu and Promote Vascularized Bone Repair

Advanced Science, EarlyView.
Diabetic bone defects remain a critical clinical challenge. A 3D‐printed BCPG‐MF@Y scaffold, embedding Yoda1‐functionalized manganese dioxide‐ferritin nanozymes, scavenges mtROS, suppresses the cGAS–STING pathway, and reverses cellular senescence, while Yoda1 activates Piezo1 to direct BMSCs fate to synergistically reprogram the osteoimmune ...
Qing‐Song Deng, Ang Wang, Ren Zhang, Xu‐Ran Li, Po‐Lin Liu, Shu‐Hang He, Zi‐Yin Han, Zhi‐Han Shen, Zhan‐Ying Wei, Chang‐Ru Zhang, Fei Wang, Helen Dawes, Jian Lu, Tong‐He Zhu, Jin‐Zhong Zhao, Shang‐Chun Guo, Shi‐Cong Tao   +16 more
wiley   +1 more source

Mitochondrial D-loop sequence variation among autochthonous horse breeds in Croatia

Czech Journal of Animal Science, 2009
Genetic variation in three Croatian coldblood horse populations was analysed using a sequence analysis of the proximal part (nt 15 498-15 821) of the D-loop region of mtDNA.
A. Ivanković, J. Ramljak, M. Konjačić, N. Kelava, P. Dovč, P. Mijić   +5 more
doaj   +1 more source