Results 81 to 90 of about 120,377 (263)

Miro1 Protects Against Acute Kidney Injury Through Modulating Mitochondrial Homeostasis via Interaction With Sirt6

Advanced Science, EarlyView.
Ischemia‐reperfusion reduces Sirt6 activity, thereby increasing Miro1 acetylation. Hyperacetylated Miro1 exhibits perinuclear distribution and degradation, thereby inducing mitochondrial dysfunction and promoting apoptosis in renal tubular epithelial cells. This pathway reveals a mechanistic link between Sirt6‐mediated deacetylation and Miro1 stability
Lin Wu, Qing Li, Yiyang Xu, Zitao Wang, Hua Shu, Yangfan Wu, Fang Lu, Zhimin Huang, Bo Zhang, Hongwei Liang, Changying Xing, Huijuan Mao, Yanggang Yuan   +12 more
wiley   +1 more source

Complete mitochondrial genome of the four-lined snake, Elaphe quatuorlineata (Bonnaterre, 1790)

Mitochondrial DNA. Part B. Resources, 2019
Here, we present complete mitochondrial genome of the four-lined snake, Elaphe quatuorlineata (Bonnaterre, 1790) and its comparison with closely related E. sauromates (Pallas, 1814).
Daniel Jablonski, Katarina Soltys, Evgeniy Simonov   +2 more
doaj   +1 more source

An Unusual Amino Acid Substitution Within Hummingbird Cytochrome c Oxidase Alters a Key Proton-Conducting Channel

G3: Genes, Genomes, Genetics, 2020
Hummingbirds in flight exhibit the highest mass-specific metabolic rate of all vertebrates. The bioenergetic requirements associated with sustained hovering flight raise the possibility of unique amino acid substitutions that would enhance aerobic ...
Cory D. Dunn, Bala Anı Akpınar, Vivek Sharma   +2 more
doaj   +1 more source

A genetic contribution from the Far East into Ashkenazi Jews via the ancient Silk Road [PDF]

, 2015
Contemporary Jews retain a genetic imprint from their Near Eastern ancestry, but obtained substantial genetic components from their neighboring populations during their history.
Jits van Straten, Li, Yu-Chun, Wang, Hua Wei, Wen Zhang, Yao, Yong-Gang, Hua-Wei Wang, Wang, Hua-Wei, Yu-Chun Li, Qing-Peng Kong, Yao, Yong Gang, Tian, Jiao-Yang, Li, Yu Chun, Kong, Qing-Peng, Jiao-Yang Tian, Richards, Martin B., Yong-Gang Yao, Tian, Jiao Yang, van Straten, Jits, Zhang, Wen, Kong, Qing Peng, Martin B. Richards   +20 more
core   +1 more source

Rocket‐Inspired Sequentially Targeted Nanotherapeutics for Mitochondrial Regulation and Inflammatory Reprogramming in Ischemic Stroke

Advanced Science, EarlyView.
A novel neutrophil‐hitchhiking, rocket‐inspired nanoplatform is developed to cross the blood‐brain barrier for sequential, spatiotemporal drug delivery. By responsive surface transformation in the ischemic penumbra, it precisely targets mitochondria to suppress Drp1‐mediated fission.
He Bai, Zihao Yong, Yang Li, Qingmin Chen, Yong Liu, Xiaomeng Guo, Fukai Li, Shicheng Tang, Zhuo Yang, Yufei Zhang, Ruwei Jie, Xiaohong Lv, Huacheng Wang, Chunming Huang, Liwei Xie, Jianqi Xiao, Qingchun Mu, Longguang Tang   +17 more
wiley   +1 more source

Stress Hyperglycemia Drives CD4+ T Cell PANoptosis and Postoperative Organ Injury via Monocyte‐Derived Succinate

Advanced Science, EarlyView.
High glucose is linked to reduced succinate dehydrogenase activity in CD14+ monocytes, accompanied by succinate accumulation and extracellular release. Extracellular succinate exacerbates mitochondrial ROS production and mtDNA release in CD4+ T cells. Cytosolic mtDNA then activates Z‐DNA binding protein 1 (ZBP1) and engages ZBP1‐associated inflammatory
Shuai Zhao, Xuemei Miao, Wei Luo, Tao Liu, Yang Wang, Jiaying Li, Di Fu, Weiyun Shen, Yan Luo, Kang Chen, Ruping Dai, Hui Li   +11 more
wiley   +1 more source

Investigating the Genetic Diversity of Squab Pigeon Breeds using Mitochondrial DNA COI Region

Scientific Papers Animal Science and Biotechnologies, 2023
Pigeon breeding is a long-established activity, with archaeological and written evidence dating back thousands of years. Hungarian pigeon breeding has been influenced from several directions in the past, as several trade routes crossed the historical ...
Katalin Balog, Lakhmi Chand Menghwar, Szilvia Kusza, Zoltán Bagi   +3 more
doaj  

Maternal Exercise Rescues Embryonic Osteogenesis Impaired due to POLG Mutation Through a Potential Apelin‐ATF4 Axis

Advanced Science, EarlyView.
Maternal exercise (ME) increases apelin abundance across maternal and fetal tissues and is associated with improved fetal osteogenesis under POLG mutation‐induced mitochondrial dysfunction. Apelin‐APJ signaling is linked to enhanced mitochondrial function, Akt phosphorylation, and ATF4‐RUNX2 association, supporting coordinated fetal bone remodeling ...
Song Ah Chae, Ryan C. Riddle, Zhihua Jiang, Chaeyoung Shin, Min Du, Jun Seok Son   +5 more
wiley   +1 more source

Acute frataxin knockdown in induced pluripotent stem cell-derived cardiomyocytes activates a type I interferon response

Disease Models & Mechanisms, 2023
M. Grazia Cotticelli, Shujuan Xia, Rachel Truitt, Nicolai M. Doliba, Andrea V. Rozo, John W. Tobias, Taehee Lee, Justin Chen, Jill S. Napierala, Marek Napierala, Wenli Yang, Robert B. Wilson   +11 more
doaj   +1 more source

GLOSSIPHONIA FERGHANENSIS SP. NOV.(ANNELIDA, HIRUDINIDA, GLOSSIPHONIIDAE): A NEW LEECH SPECIES FROM THE FERGHANA VALLEY, UZBEKISTAN

Bulletin of the Iraq Natural History Museum
A new freshwater malacophagous leech belonging to the Glossiphoniidae Vaillant, 1890 family was found in a spring in the Ferghana Valley. In this study, we describe the morphological characteristics and DNA barcoding gene of a new leech, Glossiphonia ...
Khayrulla Solijonov, Zuvayd Izzatullaev, Abdurakhim Kuchboev, Farrukh Umarov   +3 more
doaj   +1 more source