Results 61 to 70 of about 123,318 (262)
The Background of Mitochondrial DNA Haplogroup J Increases the Sensitivity of Leber's Hereditary Optic Neuropathy Cells to 2,5-Hexanedione Toxicity [PDF]
, 2009 Leber's hereditary optic neuropathy (LHON) is a maternally inherited blinding disease due to mitochondrial DNA (mtDNA) point mutations in complex I subunit genes, whose incomplete penetrance has been attributed to both genetic and environmental factors ...Achilli Alessandro, GHELLI, ANNA MARIA, Mattioli Stefano, Pala M., Barbieri, Anna, Vidoni S., Torroni Antonio, Carelli Valerio, Anna Barbieri, Vidoni, Sara, Valerio Carelli, Carelli, Valerio, Ghelli, Anna, Mattioli, Stefano, Torroni, Antonio, Iommarini, Luisa, Zanna, Claudia, Pala, Maria, Vidoni Sara, Stefano Mattioli, Antonio Torroni, Achilli A., ZANNA C, Porcelli Anna Maria, Zanna Claudia, Pala Maria, MATTIOLI S, Luisa Iommarini, GHELLI A, Achilli, Alessandro, IOMMARINI L, Rugolo, Michela, Torroni A., Porcelli, Anna Maria, CARELLI V., Ghelli Anna, Rugolo Michela, BARBIERI A, RUGOLO M, PORCELLI AM, Anna Ghelli, Barbieri Anna, Sara Vidoni, Maria Pala, Alessandro Achilli, Anna Maria Porcelli, Michela Rugolo, Claudia Zanna, Iommarini Luisa, VIDONI S +49 morecore +1 more sourceDigital Cognitive Testing in Mitochondrial Disease: Validity and Challenges for Clinical Trial Use
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Background
Primary mitochondrial disease is a group of genetic disorders caused by pathogenic variants in nuclear or mitochondrial DNA, often resulting in progressive neurodegeneration and cognitive decline. Current management is primarily supportive, though recent research offers hope for disease‐modifying treatments in the future.Oksana Pogoryelova, Jan Smeitink, Herma Renkema, Rosabeth White, Frankie Barton, Rachel Lyon, Jane Newman, Aye Moe, Yi Shiau Ng, Grainne Siobhan Gorman +9 morewiley +1 more sourceDual Role of Tamoxifen in Enhancing STING and CEACAM1 Expression to Prime a Favorable Tumor Microenvironment for Anti‐TIM3 Immunotherapy
Advanced Science, EarlyView.Anti‐PD‐1/PD‐L1 blockade has revolutionized cancer immunotherapy, but is ineffective against endocrine‐treated (i.e., Tamoxifen), relapsed ER+ breast cancer (BC) patients. This study provides insight into the sub‐optimal response of ER+BCs to anti‐PD‐1/PD‐L1 blockade – highlighting the induction of STING and the CEACAM1/TIM3 axis after chronic ...Marvin Angelo E Aberin, Saurabh Singh, Soumya Chatterjee, Guang‐Zhi Sui, Yi‐Fu Wang, Ya‐Ting Lu, Yu‐Ling Lee, Kun‐Yuan Lin, Joy Khag, Ta‐Yu Liu, Shao‐Han Chang, Wai‐Mui Cheung, Hsiao‐Chin Hong, Ren‐Jun Hsu, Chen‐Yang Shen, Chia‐Wei Li, Weng‐Lang Yang, Yao‐Ming Chang, Shih‐Yu Chen, Chandan Guha, Shu‐Ping Wang +20 morewiley +1 more sourceMitochondrial echoes of first settlement and genetic continuity in El Salvador [PDF]
, 2009 <b>Background</b>: From Paleo-Indian times to recent historical episodes, the Mesoamerican isthmus played an important role in the distribution and patterns of variability all around the double American continent.Salas Ellacuriaga, Antonio, Álvarez Iglesias, Vanesa, Carracedo, A., Lovo Gómez, José, Lareu, M.V., Cerezo Fernández, María, María Victoria Lareu, Macaulay Vincent, Cerezo María, Álvarez-Iglesias, V., Richards Martin B., Richards, M.B., Lovo-Gómez, José, Macaulay, V., Lareu, María Victoria, Carracedo, Ángel, Angel Carracedo, José Lovo-Gómez, Lovo-Gómez José, Antonio Salas, Vanesa Alvarez-Iglesias, Carracedo Álvarez, Ángel, María Cerezo, Carracedo Ángel, Martin B Richards, Salas Antonio, Salas, A., Álvarez-Iglesias Vanesa, Vincent Macaulay, Salas, Antonio, Cerezo, M., Álvarez-Iglesias, Vanesa, Macaulay, Vincent, Richards, Martin B., Lareu Huidobro, María Victoria, Lareu María Victoria, Lovo-Gómez, J., Cerezo, María +37 morecore +2 more sourcesRab1A Promotes Hepatic Steatosis by Suppressing Mitophagy via the Raf‐1/ERK1/2/PINK1 Signaling Axis
Advanced Science, EarlyView.Why does fat accumulate in the liver? Our study reveals Rab1A as the molecular switch that silences the cell's mitochondrial cleanup crew. Turning Rab1A off reactivates mitophagy, clears excess fat, and reverses fatty liver disease in mice—offering a promising new therapeutic target for MASLD, a growing global health challenge.Li Zhang, Jianhua Li, Huilu Zhang, Qi Qin, Yichen Huang, Xiaofan Tian, Chao Sun, Binbin Li, Zhengxin Wang, Xin Zhang +9 morewiley +1 more sourceMitogenomes from Two Uncommon Haplogroups Mark Late Glacial/Postglacial Expansions from the Near East and Neolithic Dispersals within Europe [PDF]
, 2013 The current human mitochondrial (mtDNA) phylogeny does not equally represent all human populations but is biased in favour of representatives originally from north and central Europe.Perego, Ugo A., Baharak Hooshiar Kashani, Gandini F, Achilli Alessandro, Woodward, Scott R., Hooshiar Kashani B, Scott R Woodward, Woodward Scott R., Ugo A. Perego (42158), Martin B. Richards (253025), Torroni Antonio, Viola Grugni, Kashani, Baharak Hooshiar, Martin B Richards, Battaglia V, Woodward SR, Francesca Gandini (150515), Anna Olivieri, Antonio Torroni (42164), Gandini, Francesca, Vincenza Battaglia (150500), Battaglia Vincenza, Torroni, Antonio, Kashani Baharak Hooshiar, Maria Pala (144910), Grugni Viola, Olivieri Anna, Grugni, Viola, Ornella Semino (150533), Pala, Maria, Baharak Hooshiar Kashani (144912), Anna Olivieri (144908), Perego UA, Richards Martin B., Ugo A Perego, Vincenza Battaglia, PEREGO, UGO ALESSANDRO, Antonio Torroni, Scott R. Woodward (42162), Ornella Semino, Pala Maria, Gandini Francesca, Battaglia, Vincenza, Achilli, Alessandro, Semino, Ornella, Francesca Gandini, Alessandro Achilli (42157), Torroni A., Olivieri A, Semino Ornella, Semino O, Grugni V, HOOSHIAR KASHANI, BAHARAK, Richards, Martin B., Richards MB, Perego Ugo A., Viola Grugni (150495), Maria Pala, Alessandro Achilli, Olivieri, Anna, Pala M, Pala, Maria; id_orcid, Richards, Martin B.; id_orcid +62 morecore +1 more sourceUltrasound‐Activatable Piezoelectric Hydrogel Reprograms Mitochondrial Epigenetics for Osteoarthritis Therapy via the mTOR/GATD3A Axis
Advanced Science, EarlyView.An ultrasound‐activatable piezoelectric hydrogel reprograms chondrocyte mitochondrial epigenetics via the mTOR/GATD3A axis, clearing damaged mitochondria and alleviating osteoarthritis progression in both mouse models and human cartilage explants. ABSTRACT
The avascular nature of cartilage hinders drug delivery for osteoarthritis (OA) therapy.Hui Zheng, Pengfei Yan, Peng Liu, Chang Yan, Mengqi Zhao, Zuyong Wang, Chao Ma, Rongkai Zhang, Xi Cui, Swee Hin Teoh +9 morewiley +1 more sourceComplete mitochondrial genomes of Baikal endemic coregonids: omul and lacustrine whitefish (Salmonidae: Coregonus sp.)
Mitochondrial DNA. Part B. Resources, 2020 Coregonid fishes are among the most successful groups in the subarctic, boreal, and subalpine fresh waters of the northern hemisphere. Limnetic–benthic sympatric species-pairs from two different evolutionary lineages, the North American lake whitefish ...Veronika Teterina, Lyubov Sukhanova, Vasiliy Smirnov, Natalya Smirnova, Sergei Kirilchik, Yulia Sapozhnikova, Olga Glizina, Vera Yakhnenko, Marina Tyagun, Tuyana Sidorova +9 moredoaj +1 more sourceMitochondrial DNA Backgrounds Might Modulate Diabetes Complications Rather than T2DM as a Whole [PDF]
, 2011 Mitochondrial dysfunction has been implicated in rare and common forms of type 2 diabetes (T2DM). Additionally, rare mitochondrial DNA (mtDNA) mutations have been shown to be causal for T2DM pathogenesis.Baharak Hooshiar Kashani, Antonella Cormio, TORRONI A., Pala M., MARRA M, Santoro Aurelia, Lancioni, Hovirag, ACHILLI A, Viola Grugni, Lancioni Hovirag, Grugni V., Cormio Antonella, Sirolla, Cristina, GRUGNI V, Anna Olivieri, Franceschi Claudio, Spazzafumo L., Cormio, Antonella, Testa Roberto, SIROLLA C, Torroni, Antonio, Ugo A. Perego, Hooshiar Kashani, Baharak, PEREGO UA, Boemi, Massimo, Grugni Viola, Olivieri Anna, Grugni, Viola, Hooshiar Kashani Baharak, Gadaleta Maria Nicola, Testa I., Bonfigli, Anna Rita, Vincenza Battaglia, PEREGO, UGO ALESSANDRO, Achilli A., Roberto Testa, Achilli A1, GANDINI F, TESTA I, Antonio Ceriello, Pala Maria, Gandini Francesca, TESTA R, Marra M., Spazzafumo, Liana, Testa R., Testa, Roberto, Semino Ornella, Marra, Maurizio, Carossa Valeria, Anna Rita Bonfigli, Cormio A, SPAZZAFUMO L, Maria Pala, Olivieri A., Ivano Testa, Olivieri, Anna, BOEMI M, Marra Maurizio, Perego, Ugo A., SANTORO A, SEMINO O, Achilli Alessandro, HOOSHIAR KASHANI B, Boemi M., Spazzafumo Liana, Battaglia V., Hooshiar Kashani B., Testa, Ivano, Aurelia Santoro, Torroni Antonio, Ceriello, Antonio, Boemi Massimo, Massimo Boemi, Valeria Carossa, Bonfigli A. R., LANCIONI H, Gandini, Francesca, Sirolla Cristina, Battaglia Vincenza, Gadaleta, Maria Nicola, BATTAGLIA V, Sirolla C., Santoro, Aurelia, Bonfigli Anna Rita, Gadaleta M. N., Ceriello A., Carossa, Valeria, CAROSSA V, Pala, Maria, FRANCESCHI C, Semino O., Ceriello Antonio, Ugo A Perego, Antonio Torroni, Maria Nicola Gadaleta, Testa Ivano, Perego U. A., BONFIGLI AR, Ornella Semino, Franceschi, Claudio, Maurizio Marra, Hovirag Lancioni, Battaglia, Vincenza, Achilli, Alessandro, Semino, Ornella, CERIELLO A, GADALETA MN, Francesca Gandini, PALA M, Carossa V., Cormio A., Lancioni H., OLIVIERI A, Perego Ugo A., Alessandro Achilli, Claudio Franceschi, Gandini F., Cristina Sirolla, Liana Spazzafumo +119 morecore +2 more sources
