Results 61 to 70 of about 72,894 (246)
Phylogenetic Network for European mtDNA [PDF]
The American Journal of Human Genetics, 2001 The sequence in the first hypervariable segment (HVS-I) of the control region has been used as a source of evolutionary information in most phylogenetic analyses of mtDNA. Population genetic inference would benefit from a better understanding of the variation in the mtDNA coding region, but, thus far, complete mtDNA sequences have been rare.
Finnilä, Saara +2 more
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Advanced Science, EarlyView.PLD3 activates the lysosomal‐AKT‐NF‐κB axis to drive cellular senescence in macrophages, establishing an immunosuppressive TME by limiting the infiltration of cytotoxic T, NK, and NKT cells, which confers resistance to anti‐PD‐1 therapy. Abrine inhibits PLD3 expression, restoring antitumor immunity and synergizing with anti‐PD‐1 treatment.
Xingtu Qin +11 more
wiley +1 more source
Mitochondrial DNA. Part B. Resources, 2019 The northern anchovy, Engraulis mordax, is a small planktivorous fish from the northeastern Pacific Ocean that is an important forage for fishes, birds, and marine mammals, and is also the target of a commercial fishery.
Olivia H. Lewis, Sean C. Lema
doaj +1 more source
Xenogeneic Mitochondrial Transplantation Improves Selected Age‐Associated Phenotypes in Mice
Advanced Science, EarlyView.Yak‐derived xenogeneic mitochondrial transplantation improves selected age‐associated phenotypes in mice, enhances mitochondrial functional readouts, and engages host mitochondrial quality‐control pathways. Broad tissue biodistribution, increased ATP production and mtDNA copy number, reduced ROS levels and dysfunctional mitochondria, improved motility ...
Wenpeng Li +5 more
wiley +1 more source
Complete mitochondrial genome of the four-lined snake, Elaphe quatuorlineata (Bonnaterre, 1790)
Mitochondrial DNA. Part B. Resources, 2019 Here, we present complete mitochondrial genome of the four-lined snake, Elaphe quatuorlineata (Bonnaterre, 1790) and its comparison with closely related E. sauromates (Pallas, 1814).
Daniel Jablonski +2 more
doaj +1 more source
G3: Genes, Genomes, Genetics, 2020 Hummingbirds in flight exhibit the highest mass-specific metabolic rate of all vertebrates. The bioenergetic requirements associated with sustained hovering flight raise the possibility of unique amino acid substitutions that would enhance aerobic ...
Cory D. Dunn +2 more
doaj +1 more source
mtDNA in the crossroads of evolution and disease [PDF]
Nature Reviews Molecular Cell Biology, 2020 Dan Mishmar recounts the first studies that used mitochondrial DNA (mtDNA) to trace the origin of humanity to Africa and that connected mtDNA mutations with a human disease.
openaire +2 more sources
Advanced Science, EarlyView.ABSTRACT Doxorubicin‐induced cardiomyopathy (DIC) remains a dose‐limiting clinical challenge. This study reveals that cardiac vascular endothelial cells (CVECs) act as initial sensors of doxorubicin cardiotoxicity: circulating doxorubicin activates the cGAS‑STING pathway in CVECs, triggering NLRP3 inflammasome‑mediated pyroptosis and release of ...
Wang Jun +10 more
wiley +1 more source
Advanced Science, EarlyView.This study uncovers that quercetin naturally targets mitochondria. By coordinating quercetin with Fe3+, we engineer an ultrasmall cascade nanozyme (MCN) with superoxide dismutase‐catalase activities. MCN crosses the damaged blood–brain barrier, scavenges mitochondrial ROS, prevents mitochondrial DNA leakage, and blocks the cGAS‐STING pathway, thereby ...
Wenxuan Zheng +14 more
wiley +1 more source
Investigating the Genetic Diversity of Squab Pigeon Breeds using Mitochondrial DNA COI Region
Scientific Papers Animal Science and Biotechnologies, 2023 Pigeon breeding is a long-established activity, with archaeological and written evidence dating back thousands of years. Hungarian pigeon breeding has been influenced from several directions in the past, as several trade routes crossed the historical ...
Katalin Balog +3 more
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