Results 61 to 70 of about 120,377 (263)

Mitochondrial SLC25A46 Rewires Fatty Acid Oxidation to Promote Cell Proliferation and Ferroptosis Evasion in Ovarian Cancer by Stabilizing CACT

Advanced Science, EarlyView.
Mitochondrial SLC25A46 is upregulated in ovarian cancer (OC) and correlates with poor prognosis. SLC25A46 stabilizes CACT to activate fatty acid oxidation, increasing ATP and NADPH production to drive cell proliferation and ferroptosis evasion. SLC25A46 silencing sensitizes OC cells to ferroptosis and carboplatin, offering a promising therapeutic ...
Yunge Gao, Jiatao Hao, Xiaohong Zhang, Meiting Long, Yujing Feng, Xiaoyue Liu, Xuejian Li, Shujuan Liu, Xin Guo, Xiaohui Lv   +9 more
wiley   +1 more source

The mtDNA diversity of captive ruffed lemurs (Varecia spp.): Implications for conservation [PDF]

, 2022
Ruffed lemurs (Varecia variegata and V. rubra) are considered Critically Endangered, and genetic studies are therefore needed for assessing the conservation value of captive populations.
Vega, R., Roullet, Delphine, Catinaud, Jerome, Kitchener, Andrew C., Roos, Christian, King, Tony, Hopper, Jane, Hollister, Jack D., Robsomanitrandrasana, Eric   +8 more
core   +1 more source

Ultrasound‐Responsive Piezoelectric Fibrous Membrane Promotes Neurological Recovery After TBI by Modulating Microglial Polarization via Restoring Mitochondrial Dynamic Homeostasis

Advanced Science, EarlyView.
We demonstrate a novel therapy for traumatic brain injury TBI using a LIPUS‐responsive Piezoelectric fibrous membrane. It targets microglial mitochondria via in situ electrical signals, restoring homeostasis and reducing oxidative stress to promote an anti‐inflammatory M2 phenotype.
Wei Li, Runzhe Huang, Qingyuan Wu, Pengbo Zhou, Dangli Ren, Jingjing Wang, Hanjie Niu, Zemeng Li, Hongtao Sun, Huiyu Liu   +9 more
wiley   +1 more source

Mitogenomes from Two Uncommon Haplogroups Mark Late Glacial/Postglacial Expansions from the Near East and Neolithic Dispersals within Europe [PDF]

, 2013
The current human mitochondrial (mtDNA) phylogeny does not equally represent all human populations but is biased in favour of representatives originally from north and central Europe.
Perego, Ugo A., Baharak Hooshiar Kashani, Gandini F, Achilli Alessandro, Woodward, Scott R., Hooshiar Kashani B, Scott R Woodward, Woodward Scott R., Ugo A. Perego (42158), Martin B. Richards (253025), Torroni Antonio, Viola Grugni, Kashani, Baharak Hooshiar, Martin B Richards, Battaglia V, Woodward SR, Francesca Gandini (150515), Anna Olivieri, Antonio Torroni (42164), Gandini, Francesca, Vincenza Battaglia (150500), Battaglia Vincenza, Torroni, Antonio, Kashani Baharak Hooshiar, Maria Pala (144910), Grugni Viola, Olivieri Anna, Grugni, Viola, Ornella Semino (150533), Pala, Maria, Baharak Hooshiar Kashani (144912), Anna Olivieri (144908), Perego UA, Richards Martin B., Ugo A Perego, Vincenza Battaglia, PEREGO, UGO ALESSANDRO, Antonio Torroni, Scott R. Woodward (42162), Ornella Semino, Pala Maria, Gandini Francesca, Battaglia, Vincenza, Achilli, Alessandro, Semino, Ornella, Francesca Gandini, Alessandro Achilli (42157), Torroni A., Olivieri A, Semino Ornella, Semino O, Grugni V, HOOSHIAR KASHANI, BAHARAK, Richards, Martin B., Richards MB, Perego Ugo A., Viola Grugni (150495), Maria Pala, Alessandro Achilli, Olivieri, Anna, Pala M   +60 more
core   +1 more source

Ultrasound‐Activatable Piezoelectric Hydrogel Reprograms Mitochondrial Epigenetics for Osteoarthritis Therapy via the mTOR/GATD3A Axis

Advanced Science, EarlyView.
An ultrasound‐activatable piezoelectric hydrogel reprograms chondrocyte mitochondrial epigenetics via the mTOR/GATD3A axis, clearing damaged mitochondria and alleviating osteoarthritis progression in both mouse models and human cartilage explants. ABSTRACT The avascular nature of cartilage hinders drug delivery for osteoarthritis (OA) therapy.
Hui Zheng, Pengfei Yan, Peng Liu, Chang Yan, Mengqi Zhao, Zuyong Wang, Chao Ma, Rongkai Zhang, Xi Cui, Swee Hin Teoh   +9 more
wiley   +1 more source

Mitochondrial stress in advanced fibrosis and cirrhosis associated with chronic hepatitis B, chronic hepatitis C, or nonalcoholic steatohepatitis

Hepatology, EarlyView., 2022
Adaptive mitochondrial mechanisms allow mitochondrial resilience and prevent the worsening of fibrosis, while deregulation of these mechanisms promotes the progression from no/minimal‐mild (F0‐F2) fibrosis to advanced fibrosis and cirrhosis (F3‐F4). Abstract Background and Aims Hepatitis B virus (HBV) infection causes oxidative stress (OS) and alters ...
Dimitri Loureiro, Issam Tout, Stéphanie Narguet, Cheikh Mohamed Bed, Morgane Roinard, Ahmad Sleiman, Nathalie Boyer, Nathalie Pons‐Kerjean, Corinne Castelnau, Nathalie Giuly, Dorothy Tonui, Vassili Soumelis, Jamel El Benna, Patrick Soussan, Richard Moreau, Valérie Paradis, Abdellah Mansouri, Tarik Asselah   +17 more
wiley   +1 more source

The Multifaceted Origin of Taurine Cattle Reflected by the Mitochondrial Genome [PDF]

, 2009
A Neolithic domestication of taurine cattle in the Fertile Crescent from local aurochsen (Bos primigenius) is generally accepted, but a genetic contribution from European aurochsen has been proposed.
Malusà, Arianna, Perego, Ugo A., Baharak Hooshiar Kashani, Baharak Hooshiar, Bandelt, Hans-Jürgen, Ferretti, Luca, Pala, Maria, Paolo Ajmone-Marsan, Silvia Bonfiglio, BANDELT HJ, Ugo A Perego, PEREGO, UGO ALESSANDRO, Hans-Jürgen Bandelt, Antonio Torroni, Ornella Semino, Ajmone-Marsan, Paolo, Ro Achilli, Achilli, Alessandro, Liotta, Luigi, Semino, Ornella, Anna Olivieri, LIOTTA L, Ajmone Marsan, Paolo, AJMONE MARSAN P, Luca Ferretti, Luigi Liotta, Torroni, Antonio, Maria Pala, Ugo A. Perego, Alessandro Achilli, Olivieri, Anna, Bonfiglio, Silvia, Arianna Malusà, Hooshiar Kashani, Baharak, MALUSA', ARIANNA, Bonfiglio S., Achilli Alessandro, Hooshiar Kashani B, Ajmone-Marsan Paolo, Pala M., Torroni Antonio, Kashani B. H., Bonfiglio S, Bandelt H. J., Liotta Luigi, Kashani Baharak Hooshiar, Ferretti L., Olivieri Anna, Malusà Arianna, Ajmone Marsan P., Perego UA, Semino O., Malusà A, Achilli A., Lotta L, Malusà A., Perego U. A., Bonfiglio Silvia, Bandelt Hans-Jürgen, Pala Maria, Ferretti Luca, Torroni A., Olivieri A, Semino Ornella, Semino O, Perego Ugo A., Olivieri A., Ferretti L, Pala M   +68 more
core   +2 more sources

Microenvironment‐Responsive Nanomedicine Enables Vertical Modulation of Mitochondrial Pathological Networks in Myocardial Ischemia–Reperfusion Injury

Advanced Science, EarlyView.
A mitochondria‐targeted, microenvironment‐responsive nanoplatform enables pH/ROS‐triggered co‐delivery of berberine and isoliensinine to orchestrate ROS scavenging, inflammation suppression, and apoptosis inhibition. This vertical modulation of mitochondrial pathological networks preserves mitochondrial function and effectively mitigates myocardial ...
Jue Wang, Jia Zhou, Wenqin Yuan, Tianjiao Zhao, Yunying Huang, Yingci Xia, Yuting Lin, Fei Li, Qiong Huang, Chong Liu, Kelong Ai, Qun Qin   +11 more
wiley   +1 more source

RIPK3 dampens mitochondrial bioenergetics and lipid droplet dynamics in metabolic liver disease

Hepatology, EarlyView., 2022
RIPK3 dampens mitochondrial bioenergetics and lipid droplet dynamics in metabolic liver disease. Abstract Background and Aims Receptor‐interacting protein kinase 3 (RIPK3) mediates NAFLD progression, but its metabolic function is unclear. Here, we aimed to investigate the role of RIPK3 in modulating mitochondria function, coupled with lipid droplet (LD)
Marta B. Afonso, Tawhidul Islam, Julie Magusto, Ricardo Amorim, Véronique Lenoir, Rui F. Simões, José Teixeira, Liana C. Silva, Dominique Wendum, Isabelle Jéru, Corinne Vigouroux, Rui E. Castro, Paulo J. Oliveira, Carina Prip‐Buus, Vlad Ratziu, Jérémie Gautheron, Cecília M. P. Rodrigues   +16 more
wiley   +1 more source

The mitochondrial genome of the endemic Brazilian paradoxical frog Pseudis tocantins (Hylidae)

Mitochondrial DNA. Part B. Resources, 2018
In this work, we present for the first time the mitochondrial genome of a paradoxical frog (Pseudis tocantins). This genome is 15.56 kb, excluding the control region, and is similar in gene content to other hylid mitogenomes. Maximum likelihood analysis,
Kaleb Pretto Gatto, Jeramiah J. Smith, Luciana Bolsoni Lourenço   +2 more
doaj   +1 more source