Results 41 to 50 of about 120,377 (263)

Role of the Nrf2/ARE Pathway in the mtDNA Reparation

Frontiers in Bioscience-Landmark
Mitochondrial DNA (mtDNA) is located in the mitochondrial matrix, in close proximity to major sources of reactive oxygen species (ROS) in the cell. This makes mtDNA one of the most susceptible components to damage in the cell.
Artem P. Gureev, Ekaterina V. Chernyshova, Ekaterina P. Krutskikh, Irina S. Sadovnikova, Elena E. Tekutskaya, Anna A. Dorohova   +5 more
doaj   +1 more source

Diagnostic molecular markers and the genetic relationships among three species of the Cheilosia canicularis group (Diptera: Syrphidae)

European Journal of Entomology, 2005
To re-evaluate the taxonomic status of Cheilosia canicularis (Panzer, 1801), C. himantopus (Panzer, 1798) and C. orthotricha Vujić & Claussen, 1994, variation in the mitochondrial DNA (mtDNA) sequence of the cytochrome c oxidase subunit I (COI) gene and ...
Vesna MILANKOV, Jelena STAMENKOVIĆ, Jasmina LUDOŠKI, Gunilla STÅHLS, Ante VUJIĆ   +4 more
doaj   +1 more source

mtDNA-CN in psoriasis patients and healthy controls.

, 2022
The mtDNA-CN was quantified by real-time qPCR in peripheral blood buffy coat samples from patients with psoriasis (n = 56) and healthy controls (n = 44). A: Bar graph of data expressed as the mean ± standard deviation (SD). B: Dot plot of data.
Suad AlFadhli (477959), Ghada Al-Kafaji (12054792), Materah Salem Alwehaidah (12054816)   +2 more
core   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

mtDNA-depleted cells have stem-like characteristics.

, 2018
(A) The mRNA expression level of cd44 was analyzed by qPCR. In both TE8 and TE11 cells, cd44 expression of mtDNA-depleted cells was significantly increased compared with control cells.
Yasunori Masuike (4857526), Yasuhiro Miyazaki (524725), Yukinori Kurokawa (4857523), Koji Tanaka (559903), Kiyokazu Nakajima (4857517), Makoto Yamasaki (813466), Tsuyoshi Takahashi (376911), Masaki Mori (30875), Yuichiro Doki (402704), Tomoki Makino (4857520)   +9 more
core   +1 more source

Maternal age effect and severe germ-line bottleneck in the inheritance of human mitochondrial DNA [PDF]

, 2014
The manifestation of mitochondrial DNA (mtDNA) diseases depends on the frequency of heteroplasmy (the presence of several alleles in an individual), yet its transmission across generations cannot be readily predicted owing to a lack of data on the size ...
Chiaromonte, Francesca, T. S. Korneliussen, D. Blankenberg, Blankenberg, Daniel, Korneliussen, Thorfinn Sand, I. M. Paul, Paul, IM, Holland, Mitchell M, Su, Marcia Shu-Wei, B. Rebolledo-Jaramillo, Su, MS-W, B. Dickins, A. Nekrutenko, McElhoe, Jennifer A., R. Nielsen, N. Stoler, Nielsen, Rasmus, Nekrutenko, A, Makova, Kateryna D., Stoler, Nicholas, McElhoe, Jennifer A, Korneliussen, Thorfinn S., Chiaromonte, F, Holland, MM, M. S.-W. Su, Nekrutenko, Anton, Nielsen, R, Makova, KD, J. A. McElhoe, Rebolledo-Jaramillo, Boris, Rebolledo-Jaramillo, B, Korneliussen, Thorfinn S, Makova, Kateryna D, M. M. Holland, Holland, Mitchell M., Stoler, N, Blankenberg, D, F. Chiaromonte, Paul, Ian M., Paul, Ian M, K. D. Makova, Korneliussen, TS, McElhoe, JA, Dickins, Benjamin, Dickins, B   +44 more
core   +1 more source

Ionomycin suppresses cancer cell growth by disrupting mitochondrial transcription

FEBS Open Bio, EarlyView.
In this study, we identify a new function for the selective Ca2+ ionophore, ionomycin, as an inhibitor of mitochondrial transcription. Both total and nascent RNA analyses revealed that ionomycin treatment reduces the transcription of mitochondrial genes.
Lishen Wang, Mingqiang Deng, Dongmei He, Diqin Lai, Dongjun Liu, Dengyong Zhu, Zhenhua Zhang, Peng Tang, Chuanman Zhou, Menghui Yin, Xichen Bao   +10 more
wiley   +1 more source

Mitochondrial echoes of first settlement and genetic continuity in El Salvador [PDF]

, 2009
<b>Background</b>: From Paleo-Indian times to recent historical episodes, the Mesoamerican isthmus played an important role in the distribution and patterns of variability all around the double American continent.
Salas Ellacuriaga, Antonio, Álvarez Iglesias, Vanesa, Carracedo, A., Lovo Gómez, José, Lareu, M.V., Cerezo Fernández, María, María Victoria Lareu, Macaulay Vincent, Cerezo María, Álvarez-Iglesias, V., Richards Martin B., Richards, M.B., Lovo-Gómez, José, Macaulay, V., Lareu, María Victoria, Carracedo, Ángel, Angel Carracedo, José Lovo-Gómez, Lovo-Gómez José, Antonio Salas, Vanesa Alvarez-Iglesias, Carracedo Álvarez, Ángel, María Cerezo, Carracedo Ángel, Martin B Richards, Salas Antonio, Salas, A., Álvarez-Iglesias Vanesa, Vincent Macaulay, Salas, Antonio, Cerezo, M., Álvarez-Iglesias, Vanesa, Macaulay, Vincent, Richards, Martin B., Lareu Huidobro, María Victoria, Lareu María Victoria, Lovo-Gómez, J., Cerezo, María   +37 more
core   +2 more sources

BCG vaccination potentiates oxidative phosphorylation in neonatal myeloid‐derived suppressor cells

FEBS Open Bio, EarlyView.
BCG vaccination enhances oxidative phosphorylation in neonatal MDSCs, impairing their immunosuppressive function. It upregulates electron transport chain genes and mitochondrial activity, increasing ATP and oxygen consumption. Pharmacological OXPHOS inhibition partially restores suppressive capacity, confirming causality.
Yingying Chen, Hui Li
wiley   +1 more source

Genetic differentiation of populations of Pseudoregma bambucicola based on mtDNA cytb gene sequences

Mitochondrial DNA. Part B. Resources, 2019
Pseudoregma bambucicola is an economically significant bamboo pest which is highly reproductive found in Eastern Asia that influences the normal growth of bamboo, induces the formation of sooty molds, and even causes substantial injury or death among ...
Xiang Nong, Sheng-Nan Zhong, Li Chen, Yao-Jun Yang, Yue Xie, Chao-Bing Luo, Chun Fu, Hua Yu, Zi Liang   +8 more
doaj   +1 more source