Results 51 to 60 of about 123,318 (262)

mtDNA-depleted cells have stem-like characteristics.

, 2018
(A) The mRNA expression level of cd44 was analyzed by qPCR. In both TE8 and TE11 cells, cd44 expression of mtDNA-depleted cells was significantly increased compared with control cells.
Yasunori Masuike (4857526), Yasuhiro Miyazaki (524725), Yukinori Kurokawa (4857523), Koji Tanaka (559903), Kiyokazu Nakajima (4857517), Makoto Yamasaki (813466), Tsuyoshi Takahashi (376911), Masaki Mori (30875), Yuichiro Doki (402704), Tomoki Makino (4857520)   +9 more
core   +1 more source

Ionomycin suppresses cancer cell growth by disrupting mitochondrial transcription

FEBS Open Bio, EarlyView.
In this study, we identify a new function for the selective Ca2+ ionophore, ionomycin, as an inhibitor of mitochondrial transcription. Both total and nascent RNA analyses revealed that ionomycin treatment reduces the transcription of mitochondrial genes.
Lishen Wang, Mingqiang Deng, Dongmei He, Diqin Lai, Dongjun Liu, Dengyong Zhu, Zhenhua Zhang, Peng Tang, Chuanman Zhou, Menghui Yin, Xichen Bao   +10 more
wiley   +1 more source

Evidence for a bimodal distribution of hybrid indices in a hybrid zone with high admixture [PDF]

Royal Society Open Science, 2015
The genetic structure of a hybrid zone can provide insights into the relative roles of the various factors that maintain the zone. Here, we use a multilocus approach to characterize a hybrid zone between two subspecies of killifish (Fundulus heteroclitus,
Jessica L. McKenzie, Rashpal S. Dhillon, Patricia M. Schulte   +2 more
doaj   +1 more source

The strength and timing of the mitochondrial bottleneck in salmon suggests a conserved mechanism in vertebrates

, 2011
In most species mitochondrial DNA (mtDNA) is inherited maternally in an apparently clonal fashion, although how this is achieved remains uncertain.
Wolff, Jonci N., Daniel J White, Michael Woodhams, Neil J. Gemmell, Gemmell, Neil J., White Daniel J., Daniel J. White, Woodhams, Michael, White, Helen E., Wolff Jonci N., Woodhams Michael, Gemmell Neil J., Neil J Gemmell, Helen E White, White, Daniel J., Jonci N. Wolff, Jonci N Wolff, Helen E. White, White Helen E.   +18 more
core   +1 more source

The First Modern Human Dispersals across Africa [PDF]

, 2013
The emergence of more refined chronologies for climate change and archaeology in prehistoric Africa, and for the evolution of human mitochondrial DNA (mtDNA), now make it feasible to test more sophisticated models of early modern human dispersals ...
Luísa Pereira, Fernandes Verónica, Farida Alshamali (484036), Rito Teresa, Fernandes, V, Fernandes, Verónica, Richards, MB, Farida Alshamali, Rito, T, Teresa Rito, Richards Martin B., Martin B. Richards (253025), Pereira Luísa, Viktor Cerny (5656840), Cerny, V, Alshamali, Farida, Cerny, Viktor, Cerny Viktor, Martin B Richards, Alshamali, F, Soares Pedro, Rito, Teresa, Pereira, L, Alshamali Farida, Viktor Cerny, Luísa Pereira (3796522), Pedro Soares, Teresa Rito (393568), Richards, Martin B., Verónica Fernandes, Soares, Pedro, Pedro Soares (393566), Pereira, Luísa, Soares, P, Verónica Fernandes (4856473), Richards, Martin B.; id_orcid   +35 more
core   +2 more sources

BCG vaccination potentiates oxidative phosphorylation in neonatal myeloid‐derived suppressor cells

FEBS Open Bio, EarlyView.
BCG vaccination enhances oxidative phosphorylation in neonatal MDSCs, impairing their immunosuppressive function. It upregulates electron transport chain genes and mitochondrial activity, increasing ATP and oxygen consumption. Pharmacological OXPHOS inhibition partially restores suppressive capacity, confirming causality.
Yingying Chen, Hui Li
wiley   +1 more source

Phylogenetic Studies on Red Junglefowl (Gallus gallus) and Native Chicken (Gallus gallus domesticus) in Samar Island, Philippines using the Mitochondrial DNA D-Loop Region

The Journal of Poultry Science, 2019
A study was conducted to provide genetic information on the matrilineal phylogeny and genetic diversity of Red junglefowl (RJF) and native chickens in Samar Island, Philippines and to identify the genetic distance between Philippine junglefowls and other
Cyrill John P. Godinez, Masahide Nishibori, Megumi Matsunaga, Dinah M. Espina   +3 more
doaj   +1 more source

In search of the genetic footprints of Sumerians: a survey of Y-chromosome and mtDNA variation in the Marsh Arabs of Iraq [PDF]

, 2011
Background For millennia, the southern part of the Mesopotamia has been a wetland region generated by the Tigris and Euphrates rivers before flowing into the Gulf.
Hamod, Mohammed A, Baharak Hooshiar Kashani, Semino, O., Augusta S Santachiara-Benerecetti, Grugni Viola, Santachiara Benerecetti, A.S., Olivieri Anna, Grugni, Viola, Pala, Maria, Al-Zahery, Nadia, Nadia Al-Zahery, Mohammed A Hamod, Hamod MA, Grugni, V., Santachiara-Benerecetti Augusta S, Vincenza Battaglia, Antonio Torroni, Santachiara Benerecetti AS, Battaglia, V., Torroni Antonio, Viola Grugni, Al-Zahery Nadia, Baharak Kashani, Ornella Semino, Kashani Baharak, Hamod, M.A., Hamod Mohammed A, Pala Maria, Battaglia, Vincenza, Semino, Ornella, Anna Olivieri, Pala, M., Semino Ornella, Kashani, B.H., Battaglia Vincenza, Olivieri, A., Al Zahery, N., Torroni, A., Torroni, Antonio, Maria Pala, Olivieri, Anna, Hooshiar Kashani, Baharak, Santachiara-Benerecetti, Augusta S   +42 more
core   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

RNA Sequencing Resolves Cryptic Pathogenic Variants in Mitochondrial Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Mitochondrial diseases are the most common inherited metabolic disorders, characterized by pronounced clinical and genetic heterogeneity that complicates molecular diagnosis. Although DNA‐based sequencing approaches have become standard in genetic testing, up to half of patients remain without a definitive diagnosis.
Zhimei Liu, Xin Duan, Fatemeh Peymani, Jia Wang, Chengjia Bao, Chaolong Xu, Ying Zou, Zixuan Zhang, Yunxi Zhang, Tongyue Li, Martin Pavlov, Junling Wang, Minhan Song, Tianyu Song, Xiaodi Han, Mingxi Sun, Danmin Shen, Ruoyu Duan, Huafang Jiang, Manting Xu, Holger Prokisch, Fang Fang   +21 more
wiley   +1 more source