Results 51 to 60 of about 72,894 (246)

Agnuside Stabilizes the Complex I Assembly Factor NDUFAF6 to Reinforce Mitochondrial Efficiency and Thermogenic Responsiveness

Advanced Science, EarlyView.
ABSTRACT Brown and beige adipocytes dissipate energy as heat, yet effective strategies to enhance their mitochondrial efficiency remain limited. Here, we identify Agnuside (AGN) as a selective stabilizer of the complex I assembly factor NDUFAF6. AGN directly binds cytosolic NDUFAF6, suppresses its ubiquitination, prolongs its half‐life, and facilitates
Qingwen Zhao, Li Xie, Qianzhuo Wang, Shuying Dai, Bei Li, Yingjuan Zhang, Zhe Sun, Yue Gao   +7 more
wiley   +1 more source

Play Around with mtDNA [PDF]

DNA and Cell Biology, 2020
Cali T., Brini M.
openaire   +2 more sources

RBM10 Deficiency Promotes Anti‐PD‐1 Resistance in LUAD via STING Alternative Splicing‐Driven CCL7 Signaling and Macrophage Polarization

Advanced Science, EarlyView.
RBM10 deficiency promotes anti‐PD‐1 resistance in lung adenocarcinoma by altering STING alternative splicing, which enhances CCL7 secretion and CCR2‐dependent M2 macrophage polarization. A positive feedback loop via mitochondrial transfer sustains this immunosuppression.
Weitong Gao, Ruqiong Wang, Bo An, Lishuang Qi, Zihan Jing, Xingmei Ren, Yang Zhou, Mingjun Xu, Jiaojiao Li, Jie Liu, Liying Wang, Gang Xu, Rou Li, Dexin Jia, Yan Yu   +14 more
wiley   +1 more source

TME/NIR Dual‐Responsive Zinc‐Based Targeted Nanoagonist for Multimodal Amplification of STING‐Mediated Cancer Immunotherapy

Advanced Science, EarlyView.
A multifunctional nanoagonist (cDZ@IP) enables nano‐metabolite–driven multimodal activation of the STING pathway and enhanced immune recognition, achieving potent antitumor immunity and suppressing tumor growth and metastasis. This strategy highlights the rational design of therapeutic metabolites and establishes a new paradigm bridging nanomedicine ...
Kepeng Hu, Jiawei Wang, Wei Zhang, Zhixuan Wu, Jing Chen, Yujing He, Xiyue Duan, Yaoting He, Xin Xin, Haoyi Xiang, Yijing Wang, Chengwei Wu, Yang Yi, Qing Meng, Yuqian Qiao, Kui Cheng, Xiaojun Long, Zhangfa Song   +17 more
wiley   +1 more source

The mitochondrial genome of the endemic Brazilian paradoxical frog Pseudis tocantins (Hylidae)

Mitochondrial DNA. Part B. Resources, 2018
In this work, we present for the first time the mitochondrial genome of a paradoxical frog (Pseudis tocantins). This genome is 15.56 kb, excluding the control region, and is similar in gene content to other hylid mitogenomes. Maximum likelihood analysis,
Kaleb Pretto Gatto, Jeramiah J. Smith, Luciana Bolsoni Lourenço   +2 more
doaj   +1 more source

Complete mitochondrial genomes of Baikal endemic coregonids: omul and lacustrine whitefish (Salmonidae: Coregonus sp.)

Mitochondrial DNA. Part B. Resources, 2020
Coregonid fishes are among the most successful groups in the subarctic, boreal, and subalpine fresh waters of the northern hemisphere. Limnetic–benthic sympatric species-pairs from two different evolutionary lineages, the North American lake whitefish ...
Veronika Teterina, Lyubov Sukhanova, Vasiliy Smirnov, Natalya Smirnova, Sergei Kirilchik, Yulia Sapozhnikova, Olga Glizina, Vera Yakhnenko, Marina Tyagun, Tuyana Sidorova   +9 more
doaj   +1 more source

MtDNA deletions and aging

Frontiers in Aging
Aging is the major risk factor in most of the leading causes of mortality worldwide, yet its fundamental causes mostly remain unclear. One of the clear hallmarks of aging is mitochondrial dysfunction. Mitochondria are best known for their roles in cellular energy generation, but they are also critical biosynthetic and signaling organelles.
Sprason, Charlotte, Tucker, Trudy, Clancy, David   +2 more
openaire   +3 more sources

Mitochondrial SLC25A46 Rewires Fatty Acid Oxidation to Promote Cell Proliferation and Ferroptosis Evasion in Ovarian Cancer by Stabilizing CACT

Advanced Science, EarlyView.
Mitochondrial SLC25A46 is upregulated in ovarian cancer (OC) and correlates with poor prognosis. SLC25A46 stabilizes CACT to activate fatty acid oxidation, increasing ATP and NADPH production to drive cell proliferation and ferroptosis evasion. SLC25A46 silencing sensitizes OC cells to ferroptosis and carboplatin, offering a promising therapeutic ...
Yunge Gao, Jiatao Hao, Xiaohong Zhang, Meiting Long, Yujing Feng, Xiaoyue Liu, Xuejian Li, Shujuan Liu, Xin Guo, Xiaohui Lv   +9 more
wiley   +1 more source

Complete mitochondrial genome of an undescribed gnomefish of the genus Scombrops (Teleostei, Scombropidae) from southern waters off Kyushu Island, Japan

Mitochondrial DNA. Part B. Resources, 2017
The complete mitochondrial genome of an undescribed gnomefish species of the genus Scombrops was determined using a PCR-based method. The total length of mitochondrial DNA (mtDNA) was 16,521 bp, and included 13 protein-coding genes, two ribosomal RNA ...
Yukako Mochizuki, Riko Yamada, Hirotoshi Shishido, Yasuji Masuda, Shizuko Nakai, Noriyuki Takai, Shiro Itoi, Haruo Sugita   +7 more
doaj   +1 more source

The complete mitochondrial genome sequence of the hawk moth, Theretra oldenlandiae (Lepidoptera: Sphingidae)

Mitochondrial DNA. Part B. Resources, 2020
In this study, we analyzed the complete mitochondrial genome sequence of the hawk moth, Theretra oldenlandiae. The complete mitogenome sequence of T. oldenlandiae was observed to be a circular molecule 15,312 bp long and consisting of 13 protein-coding ...
Xu Wang, Hao Zhang, Wei-Ying Qu, Yi-Xin Huang   +3 more
doaj   +1 more source