Results 21 to 30 of about 123,318 (262)

Transmitochondrial embryonic stem cells containing pathogenic mtDNA mutations are compromised in neuronal differentiation [PDF]

, 2009
Objectives:  Defects of the mitochondrial genome (mtDNA) cause a series of rare, mainly neurological disorders. In addition, they have been implicated in more common forms of movement disorders, dementia and the ageing process.
Turnbull, Doug, Trevelyan, Andrew, Smulders-Srinivasan, Tora, Rennie, Katherine, Acin-Perez, Rebecca, Enriquez, J. A., Rennie, K. J., Lightowlers, R. N., Smulders-Srinivasan, T. K.; id_orcid, Kirby, D. M., Whittington, M., Trevelyan, A. J., Turnbull, D. M., Acin-Perez, R., Kirby, Denise, Lightowlers, Robert, Whittington, Miles, Enriquez, Jose   +17 more
core   +1 more source

Stable genetic structure and connectivity in pollution-adapted and nearby pollution-sensitive populations of Fundulus heteroclitus [PDF]

Royal Society Open Science, 2018
Populations of the non-migratory estuarine fish Fundulus heteroclitus inhabiting the heavily polluted New Bedford Harbour (NBH) estuary have shown inherited tolerance to local pollutants introduced to their habitats in the past 100 years. Here we examine
Joaquin C. B. Nunez, Leann M. Biancani, Patrick A. Flight, Diane E. Nacci, David M. Rand, Douglas L. Crawford, Marjorie F. Oleksiak   +6 more
doaj   +1 more source

Molecular Analysis of Mazandrani native chicken population based on HVR-I region of Mitochondrial DNA [PDF]

مجله بیوتکنولوژی کشاورزی, 2010
Reserving genetic diversity in native chicken breeds of Iran because of little population size is necessary for breeding goals and increasing their production. The first step is determination of genetic diversity in existing populations.
Nasrollah Pirani, Arezou Mohammad Hashemi, Sadeq Alijani   +2 more
doaj   +1 more source

Genetic differentiation of the Volga population of the eastern imperial eagle (Aquila heliaca, Falconiformes, Accipitridae) based on the cyt b gene analysis results

Известия высших учебных заведений. Поволжский регион: Естественные науки, 2022
Background. Despite the study of the variability of the mtDNA control region of the esternimperial eagles in the Volga population, due attention was not paid to cyt b, the second mitochondrial marker.
M.D. Simakov, M.V. Korepov, A.A. Kuzmin, S.V. Titov   +3 more
doaj   +1 more source

Clinicoprognostical features of endometrial cancer patients with somatic mtDNA mutations [PDF]

, 2006
Somatic mitochondrial DNA (mtDNA) mutations have been found in a subset of endometrial cancers (EC) from different populations. We have investigated the relationship between mtDNA changes and clinical and pathological variables of women affected by ...
Bartnik, Ewa, Lorenc, Anna, Bryk, Jarek, Ewa Bartnik, Semczuk, Andrzej, Putowski, Lechoslaw, Anna Lorenc, Miotla, Pawel, Lechoslaw Putowski, Jaroslaw Bryk, Konrad Futyma, Andrzej Semczuk, Futyma, Konrad, Pawel Miotla   +13 more
core   +1 more source

mtDNA-CN is associated with known covariates in both cohorts.

, 2022
Associations between mtDNA-CN and age and sex are in the expected directions when stratifying by SHAPE study. SHAPE3 on the left, SHAPE5 on the right. (TIF)
Caleb S. Mirabal (13113377), Kerry J. Stewart (11823006), Dan E. Arking (7588586), Stephanie Y. Yang (8384520), Charles E. Newcomb (8384523)   +4 more
core   +1 more source

mtDNA-Specific Ultrasensitive Near-Infrared Fluorescent Probe Enables the Differentiation of Healthy and Apoptotic Cells

, 2022
Mitochondrial DNA (mtDNA) as a class of important genetic material is easily damaged, which can result in a series of metabolic diseases, hereditary disease, and so on.
Huiyu Niu (12569986), Kui Wang (137551), Hua Zhang (12549), Ge Wang (56838), Tony D. James (1430470), Junwei Liu (11078), Yafu Wang (11602478)   +6 more
core   +1 more source

Some limitations in the use of the mitochondrial DNA cytb gene as a molecular marker for phylogenetic and population genetic studies by the example of the Apodemus genus

Вавиловский журнал генетики и селекции, 2015
The interpretation of a signal sent by the mtDNA cytb gene as a molecular marker in phylogenetic and population genetic research can be complicated by cumulative influence of parallel mutations, i.e., the entropy of nucleotide sequences.
A. G. Lapinski, M. V. Pavlenko, L. L. Solovenchuk, V. V. Gorbachev   +3 more
doaj   +1 more source

Untangling Neolithic and Bronze Age mitochondrial lineages in South Asia

Annals of Human Biology, 2019
Two key moments shaped the extant South Asian gene pool within the last 10 thousand years (ka): the Neolithic period, with the advent of agriculture and the rise of the Harappan/Indus Valley Civilisation; and Late Bronze Age events that witnessed the ...
M. Silva, P. Justeau, S. Rodrigues, G. Oteo-Garcia, K. Dulias, G. Foody, A. Fichera, B. Yau, T. Rito, J. F. Wilson, F. Gandini, C. J. Edwards, M. Pala, P. A. Soares, M. B. Richards   +14 more
doaj   +1 more source

Association of the mtDNA m.4171C>A/MT-ND1 mutation with both optic neuropathy and bilateral brainstem lesions [PDF]

, 2014
Background: An increasing number of mitochondrial DNA (mtDNA) mutations, mainly in complex I genes, have been associated with variably overlapping phenotypes of Leber’s hereditary optic neuropathy (LHON), mitochondrial encephalomyopathy with stroke ...
Cristina Scaduto, Tonon C, Caporali L, NASSETTI, STEFANIA-ALESSANDRA, Daniela Brunetto, Nassetti, Stefania, Raffaele Lodi, Tonon, Caterina, Francesco Toni, Stipa C, Carelli V., D. Brunetto, Antonio Torroni, A. Torroni, Caterina Tonon, Leonardo Caporali, F. Gandini, Chiara La Morgia, Toni, Francesco, Toni F, Nassetti S, Lodi R, Brunetto D, Anna Olivieri, Francesca Gandini, La Morgia C, Brunetto, Daniela, Parmeggiani, Antonia, Carlotta Stipa, Gandini, Francesca, Scaduto C, C. Scaduto, Stefania Nassetti, Valerio Carelli, Stipa, Carlotta, Carelli, Valerio, Scaduto, Cristina, Lodi, Raffaele, La Morgia, Chiara, Antonia Parmeggiani, Caporali, Leonardo, Torroni, Antonio, Olivieri, Anna, A. Olivieri, Parmeggiani A   +44 more
core   +2 more sources