Results 21 to 30 of about 7,772 (216)
The mtDNA of Human Rights [PDF]
Science, Technology, & Human Values, 2017 Mitochondrial replacement therapy is a process whereby a child is created by combining the nuclear DNA of two people wishing to have a child with mitochondrial DNA (mtDNA) donated by a third person. It poses a new question as to the extent of a person’s right to know the identity of those from whom their DNA is inherited.
openaire +2 more sources
Phylogeography of Calomyscus elburzensis (Calomyscidae, Rodentia) around the Central Iranian Desert with Description of a New Subspecies in Center of Iranian Plateau [PDF]
Journal of Sciences, Islamic Republic of Iran, 2016 Calomyscus elburzensis Goodwin, 1938, was previously known from central and northern Iran to southern and southwestern Turkmenistan and northwestern Afghanistan.
S. Akbarirad, J. Darvish, M. Aliabadian
doaj
Repair of mtDNA in Vertebrates [PDF]
The American Journal of Human Genetics, 1999 The author's research is supported by National Institutes of Health grants GM29681 and ES04068.
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Mitochondrial DNA. Part B. Resources, 2022 The complete mitochondrial genomes were sequenced from three individuals of the endemic charr Salvelinus sp. 4 [ from Lake Nachikinskoe (Kamchatka, Russia). The complete mitochondrial genomes were 16,654 bp in size; the genome organization and GC content
Alla G. Oleinik +2 more
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Twinkle helicase is essential for mtDNA maintenance and regulates mtDNA copy number [PDF]
Human Molecular Genetics, 2004 Mechanisms of mitochondrial DNA (mtDNA) maintenance have recently gained wide interest owing to their role in inherited diseases as well as in aging. Twinkle is a new mitochondrial 5'-3' DNA helicase, defects of which we have previously shown to underlie a mitochondrial disease, progressive external ophthalmoplegia with multiple mtDNA deletions.
Henna, Tyynismaa +9 more
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Ancient mtDNA Genetic Variants Modulate mtDNA Transcription and Replication
PLoS Genetics, 2009 Although the functional consequences of mitochondrial DNA (mtDNA) genetic backgrounds (haplotypes, haplogroups) have been demonstrated by both disease association studies and cell culture experiments, it is not clear which of the mutations within the haplogroup carry functional implications and which are "evolutionary silent hitchhikers".
Suissa, Sarit +8 more
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FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source
Hepatology, EarlyView., 2022 Adaptive mitochondrial mechanisms allow mitochondrial resilience and prevent the worsening of fibrosis, while deregulation of these mechanisms promotes the progression from no/minimal‐mild (F0‐F2) fibrosis to advanced fibrosis and cirrhosis (F3‐F4). Abstract Background and Aims Hepatitis B virus (HBV) infection causes oxidative stress (OS) and alters ...
Dimitri Loureiro +17 more
wiley +1 more source
Role of the Nrf2/ARE Pathway in the mtDNA Reparation
Frontiers in Bioscience-LandmarkMitochondrial DNA (mtDNA) is located in the mitochondrial matrix, in close proximity to major sources of reactive oxygen species (ROS) in the cell. This makes mtDNA one of the most susceptible components to damage in the cell.
Artem P. Gureev +5 more
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