Mitochondria-Targeted Multimodal Nanotherapeutics Suppress Oxidized mtDNA-Driven Inflammation at the Source. [PDF]
Adv Sci (Weinh)Ox‐mtDNA fragments escaping from mitochondria drive robust inflammatory responses. A targeted nanoplatform simultaneously inhibits mitochondrial FEN1‐mediated mtDNA cleavage and scavenges ROS, preventing the generation of immunogenic Ox‐mtDNA fragments. The released SeNPs further promote autophagic clearance of cytosolic mtDNA. Consequently, cGAS‐STING,
Li WL +7 more
europepmc +2 more sources
High-resolution mtDNA evidence for the late-glacial resettlement of Europe from an Iberian refugium [PDF]
, 2005 The advent of complete mitochondrial DNA (mtDNA) sequence data has ushered in a new phase of human evolutionary studies. Even quite limited volumes of complete mtDNA sequence data can now be used to identify the critical polymorphisms that define sub ...
Albarrán, Cristina +25 more
core +1 more source
Transmitochondrial embryonic stem cells containing pathogenic mtDNA mutations are compromised in neuronal differentiation [PDF]
, 2009 Objectives: Defects of the mitochondrial genome (mtDNA) cause a series of rare, mainly neurological disorders. In addition, they have been implicated in more common forms of movement disorders, dementia and the ageing process.
Smulders-Srinivasan, T. K. +18 more
core +1 more source
Macrophage RSAD2 Couples mtDNA Synthesis With a Self-Amplifying Inflammatory Circuit to Orchestrate Tissue Repair. [PDF]
Adv Sci (Weinh)Macrophage RSAD2 dually regulates CMPK2—the rate‐limiting enzyme for mitochondrial DNA synthesis—by suppressing its ubiquitination and promoting its phosphorylation via Csnk2a2 recruitment. This amplifies mtDNA production, which simultaneously activates a cGAS‐STING‐IRF3‐RSAD2 feedforward loop and the NLRP3 inflammasome, driving a self‐sustaining ...
Yuan H +16 more
europepmc +2 more sources
Genotyping human ancient mtDNA control and coding region polymorphisms with a multiplexed Single-Base-Extension assay: the singular maternal history of the Tyrolean Iceman [PDF]
, 2009 Background Progress in the field of human ancient DNA studies has been severely restricted due to the myriad sources of potential contamination, and because of the pronounced difficulty in identifying authentic results.
Endicott, Phillip +31 more
core +1 more source
mtDNA-CN is correlated with study retention.
, 2022 Individuals who dropped out of the study had significantly higher mtDNA-CN. (TIF)
Caleb S. Mirabal (13113377) +4 more
core +1 more source
Clinicoprognostical features of endometrial cancer patients with somatic mtDNA mutations [PDF]
, 2006 Somatic mitochondrial DNA (mtDNA) mutations have been found in a subset of endometrial cancers (EC) from different populations. We have investigated the relationship between mtDNA changes and clinical and pathological variables of women affected by ...
Bartnik, Ewa +13 more
core +1 more source
Molecular Analysis of Mazandrani native chicken population based on HVR-I region of Mitochondrial DNA [PDF]
مجله بیوتکنولوژی کشاورزی, 2010 Reserving genetic diversity in native chicken breeds of Iran because of little population size is necessary for breeding goals and increasing their production. The first step is determination of genetic diversity in existing populations.
Nasrollah Pirani +2 more
doaj +1 more source
Control control control : a reassessment and comparison of GenBank and chromatogram mtDNA sequence variation in Baltic grey seals (Halichoerus grypus) [PDF]
, 2013 This study was funded by an ‘EU bonus’ award given to MTP Gilbert by the University of Copenhagen.Genetic data can provide a powerful tool for those interested in the biology, management and conservation of wildlife, but also lead to erroneous ...
Katharina Fietz +8 more
core +2 more sources