Results 91 to 100 of about 72,894 (246)

Oxidative stress triggers neuronal injury and mouse pain sensitization by up-regulating TDP-43 to activate mtDNA-cGAS/STING pathway

陆军军医大学学报
Objective To investigate the role and possible mechanisms of transactive response DNA binding protein 43 (TDP-43) in mediating neuronal injury induced by oxidative stress in mouse neuro-2a (N2a) cells and mouse pain sensitization.
LI Li, HUANG Penghui, CUI Jian
doaj   +1 more source

Immune Modulatory Therapy for Severe Dengue Hemorrhagic Fever in a Patient With Mitochondrial Complex I Deficiency: A Case Report

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Dengue virus (DENV) poses a serious global health challenge, particularly in cases of dengue hemorrhagic fever (DHF). Patients with preexisting mitochondrial disorders may be at increased risk for complications due to the specific impact of DENV on mitochondrial‐dependent cellular processes and immune function.
Audra N. Iness, Ameya S. Walimbe, Emily R. Strouphauer, Michio Hirano, Alejandro D. Iglesias, Valentina Emmanuele, Caitlin C. Griffin, Sheldon L. Kaplan, William A. Gomes, Karen K. Moeller, Stephen F. Kralik, Fernando Scaglia   +11 more
wiley   +1 more source

Genetic identification of a non-native species introgression into wild population of the field cricket Gryllus campestris (Orthoptera: Gryllidae) in Central Europe

European Journal of Entomology, 2016
Two species of the genus Gryllus occur in Europe: G. campestris and G. bimaculatus. The first is widely distributed in the north-western Palaearctic, while the second, G. bimaculatus, occurs predominantly in the Mediterranean area.
Hanna PANAGIOTOPOULOU, Mateusz BACA, Katarzyna BACA, Paweł SIENKIEWICZ, Piotr ŚLIPIŃSKI, Michał ŻMIHORSKI   +5 more
doaj   +1 more source

One‐step generation of heritable mitochondrial DNA multiplex‐engineered rats using DddA‐derived cytosine base editor

Animal Models and Experimental Medicine, EarlyView.
We established that mixed DdCBE microinjection is an efficient, heritable, and precise strategy for generating multiplex mtDNA mutant rats. This advancement significantly expands the utility of DdCBEs for mitochondrial disease modeling, providing a robust platform for exploring the pathogenic mechanisms of complex mtDNA mutations and developing ...
Xu Zhang, Keru Li, Lei Tan, Wei Chen, Shan Gao, Chenyang Liu, Shuo Pan, Jiayue He, Ning Liu, Gefan Wan, Wei Dong, Weining Kong, Bin Shen, Xiaolong Qi, Yuanwu Ma   +14 more
wiley   +1 more source

Genetic and morphological differentiation between isolated Polish populations of "glacial relict", an endangered butterfly, Oeneis jutta (Lepidoptera: Nymphalidae)

European Journal of Entomology, 2010
This is the first study of the morphological and molecular variation in two peripheral populations of the butterfly Jutta Arctic, Oeneis jutta, a glacial relict species endangered by the fragmentation of its habitat in Poland.
Lech KRZYSZTOFIAK, Anna KRZYSZTOFIAK, Krzysztof FRĄCKIEL, Anna BIAŁA, Adrianna KILIKOWSKA, Jerzy SELL   +5 more
doaj   +1 more source

FAM43A coordinates mtDNA replication and mitochondrial biogenesis in response to mtDNA depletion

Journal of Cell Biology
Mitochondrial retrograde signaling (MRS) pathways relay the functional status of mitochondria to elicit homeostatic or adaptive changes in nuclear gene expression. Budding yeast have “intergenomic signaling” pathways that sense the amount of mitochondrial DNA (mtDNA) independently of oxidative phosphorylation (OXPHOS), the primary function of genes ...
Alva G. Sainz, Gladys R. Rojas, Alexandra G. Moyzis, Matthew P. Donnelly, Kailash C. Mangalhara, Melissa A. Johnson, Pau B. Esparza-Moltó, Kym J. Grae, Reuben J. Shaw, Gerald S. Shadel   +9 more
openaire   +2 more sources

mtDNA robs nuclear dNTPs [PDF]

Nature Reviews Molecular Cell Biology, 2019
Mitochondrial DNA damage causes ageing by having a negative effect on nuclear DNA replication and genome integrity.
openaire   +2 more sources

Comparative micro‐ornamentation patterns of reptile skin: Phylogeny‐ecology debate and species‐specific variations

The Anatomical Record, EarlyView.
Phylogenetic limitations seem more decisive than life habit in the diversity of reptile skin micro‐ornamentation. The ancestral form possibly had polygonal cells with regular borders, smooth surface and had no ridges. Cell morphology change gradually on a single scale, especially widths at scale base are greater than those at middle.
Melodi Yenmiş
wiley   +1 more source

Isolation and characterization of mitochondrial DNA from the endangered white-clawed crayfish Austropotamobius pallipes pallipes, Lereboullet, 1858

Knowledge and Management of Aquatic Ecosystems, 1996
Mitochondrial DNA (mtDNA) variation in the white-clawed crayfish, Austropotamobius pallipes pallipes, was examined by restriction endonuclease analysis of samples obtained from three geographical locations representing two very différent habitats : the ...
GRANDJEAN F., SOUTY-GROSSET C.
doaj   +1 more source

Reduction of Ribonucleotide Reductase Subunit RRM2 Potentially Impairs Gut Function of Woody Breast Broilers

Animal Research and One Health, EarlyView.
Woody breast compromises meat quality leading to reduced consumer appeal. Although its causes are unclear, improvements observed with certain dietary supplements suggest that gut health may influence woody breast development. Ribonucleotide reductase subunit RRM2 is vital for mitochondrial function and gastrointestinal integrity, and alteration in its ...
Majid Shakeri, Elizabeth Ziabtchenko, Janghan Choi, Caitlin E. Harris, Richard J. Buhr, Trevor R. Mitchell, Byungwhi Kong, Hong Zhuang, Brian Bowker   +8 more
wiley   +1 more source