Results 81 to 90 of about 26,586 (174)

The Association of the MTHFR Gene Polymorphisms with Breast Cancer Susceptibility

Majallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Īlām, 2023
Introduction: Breast cancer is the most common malignancy in women worldwide. It is also the second leading cause of cancer death among women after lung cancer.
Ahmad Hamta, Zahra Bozorgi Moghadam
doaj  

MTHFR C677T polymorphism increases MTX sensitivity via the inhibition of S-adenosylmethionine and de novo purine synthesis

, 2023
Objective: Currently, no guidelines are established for pharmacogenomic testing involving folate metabolic genes in long-term disease-modifying antirheumatic drugs' (DMARD) therapies.
Yi-Cheng Wang, En-Pei Isabel Chiang, Der-Yuan Chen, Ming-Tsung Wu, Hsin-An Ko, Barry Shane, Wen-Nan Huang, Feng-Yao Tang   +7 more
core  

Associations of methylenetetrahydrofolate reductase C677T genotype with blood pressure levels in Chinese population with essential hypertension

Clinical and Experimental Hypertension, 2018
Objective: To confirm the association between baseline blood pressure (BP) levels and the methylenetetrahydrofolate reductase (MTHFR) C677T gene polymorphism in patients with essential hypertension. Methods: A total of 347 patients were enrolled from the
Jun Cheng, Fang Tao, Yanhong Liu, Scott A. Venners, Yi-Hsiang Hsu, Shanqun Jiang, Justin Weinstock, Binyan Wang, Genfu Tang, Xiping Xu   +9 more
doaj   +1 more source

A Novel Homozygous Non-sense Mutation in the Catalytic Domain of MTHFR Causes Severe 5,10-Methylenetetrahydrofolate Reductase Deficiency

Frontiers in Neurology, 2019
Background: Severe 5,10-methylenetetrahydrofolate reductase (MTHFR) deficiency is a heterogeneous metabolic disorder inherited in an autosomal recessive manner. Pathogenic mutations in MTHFR gene have been associated with severe MTHFR deficiency.
Salam Massadeh, Salam Massadeh, Muhammad Umair, Manal Alaamery, Manal Alaamery, Majid Alfadhel, Majid Alfadhel   +6 more
doaj   +1 more source

MTHFR C677T polymorphism and risk of nonsyndromic cleft lip with or without cleft palate in the Moroccan population

, 2019
Amine Rafik,1,2 Laila Rachad,2 Abdou-samad Kone,2 Sellama Nadifi2 1Department of Plastic Surgery, Alfarbi Hospital, Oujda, Morocco; 2Laboratory of Medical Genetics and Molecular Pathology, Faculty of Medicine and Pharmacy Casablanca, University Hassan II,
Rachad L, Kone A, Rafik A, Nadifi S
core  

Role of Methylenetetrahydrofolate Reductase Gene (MTHFR) 677C>T Polymorphism in Pediatric Cerebrovascular Disorders

, 2011
Homozygosity for the methylenetetrahydrofolate reductase (MTHFR) 677C>T mutation (MTHFR TT) has been linked to an increased risk for stroke, coronary artery disease, and migraine headaches.
Samir B. Kahwash, Geoffrey L. Heyer, Hamza Alsayouf, A. Latif Khuhro, Emily C. de los Reyes, Khaled M. Zamel   +5 more
core   +1 more source

Development of a novel liquid chromatography-tandem mass spectrometry based enzymatic assay of 5,10-methylenetetrahydrofolate reductase

Scientific Reports
5,10-methylenetetrahydrofolate reductase (MTHFR) deficiency is the most common folate metabolism disorder. MTHFR is a key enzyme in the folate cycle that catalyzes the conversion of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate (5-methyl THF)
Kohei Sunoki, Miyuki Watanabe, Shiho Aoki, Eriko Jimbo, Hiroko Shimbo, Tomohide Goto, Hitoshi Osaka   +6 more
doaj   +1 more source

Association of the mthfr 677C>T polymorphism with obesity and biochemical variables in a young population of Mexico [PDF]

Journal of Medical Biochemistry, 2019
Background: Methylenetetrahydrofolate reductase (MTHFR) gene polymorphisms have been associated with overweight people and obesity. The goal of this study was to investigate the relationship of the MTHFR 677C>T polymorphism with obesity and biochemical ...
Leal-Ugarte Evelia, Peralta-Leal Valeria, Meza-Espinoza Pablo Juan, Durân-Gonzâlez Jorge, Macias-Gomez Nelly, Bocanegra-Alonso Anabel, Lara-Ramos José Ramon   +6 more
doaj  

Correlation of MTHFR C677T Polymorphism with Male Infertility among Indian Population: Case-Control Study

Journal of Pharmacy and Bioallied Sciences
This case-control study investigated the correlation between male infertility in India and the methylenetetrahydrofolate reductase (MTHFR) C677T variant.
Akash More, Namrata Anjankar, Jarul Shrivastava, Nancy Nair, Ritesh Jadhav   +4 more
doaj   +1 more source