Results 61 to 70 of about 26,586 (174)

The potential role of the MTHFR C677T polymorphism in the pathogenetic mechanisms of hormonal and metabolic response to antihyperglycemic therapy

Mìžnarodnij Endokrinologìčnij Žurnal
Background. Type 2 diabetes mellitus (T2DM) is a multifactorial disease involving both environmental and genetic components. The methylenetetrahydrofolate reductase (MTHFR) gene, particularly the C677T polymorphism, influences folate metabolism and ...
Т. Тижненко, К. Місюра, О. Плохотніченко, А. Почерняєв, А. Колеснікова, І. Мараховський, М. Горшунська, Ж. Лещенко, E. Jansen, K. Biernot Pamuła   +9 more
doaj   +1 more source

Pro‐Carcinogenic Implications of Folic Acid Supplementation During Chemically Induced Cutaneous Squamous Cell Carcinoma in Mice

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 10, October 2026.
The findings of the present study indicated that folic acid supplementation may promote skin tumorigenesis through increased proliferation, enhanced DNA damage, and impaired DNA repair mechanisms, but the results are not indicative of any dose response effect.
Neha Arora Chugh, Shashi Bala, Tuhin Mallick, Ashwani Koul   +3 more
wiley   +1 more source

MTHFR genotyping (rs181133) using different PCR methodologies.

, 2023
MTHFR genotyping (rs181133) using different PCR methodologies.
Wendell Palôma Maria dos Santos Reis (17304736), Alain Kohl (252931), Lindomar Pena (210296), Suelen Cristina de Lima (4499494), Marcos André Cavalcanti Bezerra (3108192), Jurandy Júnior Ferraz de Magalhães (17304739), Ronaldo Nascimento de Oliveira Magalhães (17304742), Ronaldo Celerino da Silva (17304733), Brijesh Rathi (818195)   +8 more
core   +1 more source

Hyperhomocysteinemia and Vitamin B Deficiency as Potential Aggravating Factors in Huntington's Disease: A Prospective Monocentric Study

Movement Disorders, Volume 41, Issue 10, Page 2712-2722, October 2026.
Abstract Background Although not confirmed, some studies have suggested that elevated homocysteine levels are common in patients with Huntington's disease (HD). Its clinical relevance remains unclear. Objectives We aimed to assess vitamin B and homocysteine levels in HD patients and explore the relationships among hyperhomocysteinemia, vitamin B ...
Salomé Puisieux, Elise Pourié, Céline Bonnet, Lucie Hopes, Solène Frismand, Myriam Bronner, Virginie Roth, Marion Wandzel, Natacha Sloboda, Laetitia Lambert, Abderrahim Oussalah, Amélia Julien, Irina Rotaru, Rosa‐Maria Guéant‐Rodriguez, Jean Louis Guéant, Carine Bossenmeyer‐Pourié, Mathilde Renaud   +16 more
wiley   +1 more source

Association of MTHFR C677T polymorphism with male infertile in Xiamen area [PDF]

, 2017
目的探讨亚甲基四氢叶酸还原酶（MTHFR）C677T基因多态性与男性不育的相关性。方法选取少、弱精症患者66例和无精症患者74例为实验组,精液正常且有正常孕育史的男性96例为对照组,分析MTHFR C677T基因多态性在三组中分布的差异。结果与对照组相比,少、弱精组中MTHFR C677T各基因型的频率差异没有显著性意义（P〉0.05）;与对照组相比,无精组中MTHFR C677T各基因型的频率差异没有显著性意义（P〉0.05）。结论在少、弱精症患者、无精症患者和健康人中,基因多态性分布无显著差异 ...
谭振军, 王厚照, 马芳芳
core   +1 more source

Analysis of Whole Exome Sequencing Results of Type 2 Diabetic Pedigree

Molecular Genetics &Genomic Medicine, Volume 14, Issue 10, October 2026.
Mutations of EPHX3 gene rs760409070[c.778 G>A (p.Glu260Lys)] and FHOD1 gene rs142023201 [c.1493 A>G (p.Asn498Ser)] are likely contributing genetic factors to T2DM in this pedigree. Based on bioinformatic analysis, we hypothesize that these mutations may promote diabetes pathogenesis by reducing peripheral insulin sensitivity, impairing glucose uptake ...
Jie Chen, Jia‐Li Li, He‐Jia Yin, Wei‐Chang Guo, Hui‐Fang Li   +4 more
wiley   +1 more source

When to Trust Epigenetic Clocks: Avoiding False Positives in Aging Interventions

Aging Cell, Volume 25, Issue 10, October 2026.
When only one epigenetic clock responds to an intervention, noise and clock‐specific biology predict the same result. We propose three criteria that increase confidence in a reported change: reliable PC‐based clocks respond, mortality‐trained or pace‐of‐aging clocks respond, and multiple clocks respond in the same direction.
Daniel S. Borrus, Raghav Sehgal, Jenel Fraij Armstrong, Jessica Kasamoto, John Gonzalez, Albert Higgins‐Chen   +5 more
wiley   +1 more source

Meta-analysis, forest plot and pooled ORs of risk from studies investigating MTHFR C677T polymorphism (TT vs CC) -stroke, homocysteine-stroke and homocysteine-MTHFR C677T.

, 2013
Meta-analysis, forest plot and pooled ORs of risk from studies investigating MTHFR C677T polymorphism (TT vs CC) -stroke, homocysteine-stroke and homocysteine-MTHFR C677T.
Pankaj Sharma (58141), Paul Bentley (253406), Thomas Marjot (386810), Muhammad S. Khan (386811), Sunaina Yadav (386808), Nazeeha Hasan (386809), Kameshwar Prasad (386812)   +6 more
core   +1 more source

Mechanism‐Driven Nanoformulations for Cognitive Impairment Induced by Intermittent Hypoxia and Periodontitis

Advanced Materials, Volume 38, Issue 49, 1 September 2026.
Clinically, intermittent hypoxia (IH) is often accompanied by periodontitis, which accelerates cognitive impairment induced by IH. Novel Janus mesoporous gold‐silica nanoformulations (RVG‐Au&mSiO2‐TPP‐VB) enable intranasal delivery, achieve hierarchical targeting to neuronal mitochondria, effectively scavenge reactive oxygen species, inhibit the HIF‐1α/
Kai‐Run Zhang, Tianbao Zhu, An‐Qi Liu, Jia‐Jia Deng, Ya‐Li Han, Sheng‐Cai Qi, Xue Liu, Tian‐Yi Jiang, Ming‐Rui Zhai, Yu‐Ying He, Xiu‐Juan Li, Hong‐Ting Da, Rui Xu, Xiaomin Li, Jun Gao, Yue‐Hua Liu   +15 more
wiley   +1 more source

Study of Methylene Tetrahydrofolate Reductase (MTHFR C677T) Single Nucleotide Polymorphism in Preeclampsia

National Board of Examinations Journal of Medical Sciences
Background: Preeclampsia is a common high blood pressure problem during pregnancy and is an important cause of illness and death in both mothers and babies. A genetic variation called MTHFR C677T may play a role in causing preeclampsia.
S. Vinitha, B. Anitha, Vasmathie S, Saravanan T   +3 more
doaj   +1 more source