Results 131 to 140 of about 424,341 (313)

Supplementary Movie 1 from mTOR Signaling Feedback Modulates Mammary Epithelial Differentiation and Restrains Invasion Downstream of <i>PTEN</i> Loss

, 2023
Susmita Ghosh, Lidenys Varela, Anil K. Sood, Ben Ho Park, Tamara L. Lotan   +4 more
openalex   +1 more source

Serotonergic System‐Targeted Nucleic Acid Hydrogel Coordinates Excitability Restoration and Circuit Reconstruction for Spinal Cord Injury Therapy

Advanced Materials, EarlyView.
The study reports a DNA/RNA heteroduplex hydrogel (SeroPTEN‐CG) that undergoes DNase‐mediated hydrogel‐to‐nanogel transition for spinal cord injury therapy by targeting the serotonergic system, combining 5‐hydroxytryptamine (5‐HT)‐mediated excitability restoration to reactivate dormant interneurons with phosphatase and tensin homolog (PTEN)‐targeted ...
Chunlin Li, Xiaoqing Zhao, Kai Jiang, Haixia Kang, Shuo Liu, Linlin Jiang, Baoshuai Bai, Haonan Cui, Ziyang Zhang, Menglei Dong, Ruizhi Zhang, Chenbo Zou, Shenghui Shang, Chi Zhang, Xiangchuang Fan, Lijuan Zhu, Huiquan Duan, Chuan Zhang, Shiqing Feng, Hengxing Zhou   +19 more
wiley   +1 more source

MTOR‐initiated metabolic switch and degeneration in the retinal pigment epithelium

, 2020
Young‐Mi Go, Jing Zhang, Jolyn Fernandes, Christopher Litwin, Rui Chen, Theodore G. Wensel, Dean P. Jones, Jiyang Cai, Yan Chen   +8 more
openalex   +2 more sources

Supplementary Table 1 from Gene Expression Profiling in True Interval Breast Cancer Reveals Overactivation of the mTOR Signaling Pathway

, 2023
Federico Rojo, Laia Domingo, María Sala, Sandra Zazo, Cristina Chamizo, Sílvia Menéndez, Oriol Arpí, Josep Corominas, Rafael Bragado, Sònia Servitja, Ignasi Tusquets, Lara Nonell, Francesc Macià, Juan José Martínez, Ana Rovira, Joan Albanell, Xavier Castells   +16 more
openalex   +1 more source

Time-Dependent Changes in Hepatic Sphingolipid Accumulation and PI3K/Akt/mTOR Signaling Pathway in a Rat Model of NAFLD [PDF]

, 2021
Klaudia Sztolsztener, Karolina Konstantynowicz-Nowicka, Ewa Harasim‐Symbor, Adrian Chabowski   +3 more
openalex   +1 more source

Piezoelectric Stimulation of Neural Cells: Exploring the Synergistic Potential of Hybrid Scaffolds for Enhanced Regeneration

Advanced Materials Interfaces, EarlyView.
Hybrid piezoelectric scaffolds offer a promising route for Central Nervous System regeneration by combining structural and electrical cues to support neural stem cell growth. This review highlights their potential to overcome current challenges in neural tissue engineering by exploring porous hybrid materials, their biological interactions, and ...
Heather F. Titterton, Chris R. Bowen, Hamideh Khanbareh   +2 more
wiley   +1 more source

Multiomics Analyses Reveal an Essential Role of Tryptophan in Treatment of csDMARDs in Rheumatoid Arthritis

Advanced Science, EarlyView.
Rheumatoid arthritis is a disease characterized by joint inflammation. Approximately 50% of patients show insufficient response to traditional synthetic disease‐modifying antirheumatic drugs. This study aims to elucidate differential molecular profiles of the mechanisms underlying drug responses through multi‐omics strategy.
Congcong Jian, Jing Zhu, Jianhong Wu, Yan Zhang, Jianghua Chen, Huan Wang, Hengyan Liu, Ke Xu, Jiaxin Huang, Xiaoting Zhu, Yuanli Wei, Shilin Li, Tingting Wang, Xuan Huang, Qinghua Zou, Jie Zhang, Jiang Su, Xinming Du, Yaping Lu, Tianci Zhou, Yingtong Zhou, Minglong Tang, Bin Li, Xue Zhou, Qihao Wei, Qiulong Yan, Fanxin Zeng   +26 more
wiley   +1 more source

Design and development of novel 1,2,3-triazole chalcone derivatives as potential anti-osteosarcoma agents via inhibition of PI3K/Akt/mTOR signalling pathway [PDF]

, 2022
Qing Su, Baolin Xu, Zhoubin Tian, Ziling Gong   +3 more
openalex   +1 more source

IL1R2 Marks and Sorts a Spermatogonial Stem Cell Population Critical for Restoring Spermatogenesis Upon Interruption in Mammals

Advanced Science, EarlyView.
Spermatogonial stem cells (SSCs) provide critical support to spermatogenesis. Here, the author established Il1r2 as a sorting marker for SSCs, with which further insights into the SSC heterogeneity and dynamic features can be obtained. They also confirmed findings in both mouse and human, thus validating IL1R2 as the surface marker for isolating and ...
Pengyu Li, Zexuan Zhang, Zihan Xie, Cheng Jin, Zhipeng Wang, Changwei Yuan, Jun Zhu, Jielin Tang, Mengzhen Li, Dingfeng Zou, Xinyu Mang, Jun Liu, Dingyao Chen, Qi Geng, Yan Lu, Ning Zhang, Shiying Miao, Jing Peng, Kai Li, Wei Song   +19 more
wiley   +1 more source

Yu Nu Compound Regulates Autophagy and Apoptosis Through mTOR in vivo and vitro

Diabetes, Metabolic Syndrome and Obesity, 2020
Caigu He,1 Guang Liu,1 Shuting Zhuang,2 Jialin Zhang,2 Yangtao Chen,1 Hetian Li,1 Zhengping Huang,1 Yanfang Zheng3 1Department of Histology and Embryology, Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian 350122, People’s Republic ...
He C, Liu G, Zhuang S, Zhang J, Chen Y, Li H, Huang Z, Zheng Y   +7 more
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